当前位置： SCI文献检索 > COMPUTATIONAL BIOLOGY AND CHEMISTRY期刊下所有文献 > Disruption of murine Tcte3-3 induces tissue specific apoptosis via co-expression of Anxa5 and Pebp1.

Disruption of murine Tcte3-3 induces tissue specific apoptosis via co-expression of Anxa5 and Pebp1.

Abstract：

:Programmed cell death or apoptosis plays a vital physiological role in the development and homeostasis. Any discrepancy in apoptosis may trigger testicular and neurodegenerative diseases, ischemic damage, autoimmune disorders and many types of cancer. Tcte3 (T-complex testis expressed 3) is an accessory component of axonemal and cytoplasmic dynein which expresses predominantly in meiotic and postmeiotic germ cells. It plays an essential role during spermatogenesis; however, to explore its diverse and complex functioning in male germ cell apoptosis, requires further prosecution. Here, 2D-gel electrophoresis, mass spectrometry and qRT-PCR analyses were performed to elucidate the differential expression of genes, in both wild-type and homozygous Tcte3-3 mice. We observed an increased expression of Tcte3 in homozygotes as compared to wild-type testes. Perpetually, an increased expression of Anxa5 and Pebp1, while a lower expression of Rsph1 was detected in Tcte3-3-/- mice. We propose that over-expression of Pebp1 and Anxa5 in Tcte3-3-/- testes might be due to increased apoptosis. To evaluate this possibility, testes specific microarray data set extracted from NCBI gene ontology omnibus (GEO) was used to cluster the possible co-expression partners of Tcte3. Further functional coherence of compiled candidate genes was monitored computationally by studying the common TFBS overlapped at the regulatory regions. Differential expression of Tcte3-3 and its involvement in apoptosis may provide a basis for the investigation of transcriptional specificities of other Tcte3 paralogs (Tcte3-1 and Tcte3-2). A complete understanding of controlling factors which have implications in regulating tissue-specific Tcte3 expression would provide additional insights into the gene control events. The collective knowledge may prove useful for the development of novel therapeutic regimen and would open new avenues in defining selective roles of Tcte3 in germ cell development.

journal_name

Comput Biol Chem

journal_title

Computational biology and chemistry

authors

Parveen Z,Bibi Z,Bibi N,Neesen J,Rashid S

doi

10.1016/j.compbiolchem.2014.10.005

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

214-225

eissn

1476-9271

issn

1476-928X

pii

S1476-9271(14)00128-5

journal_volume

53PB

pub_type

杂志文章

相关文献

COMPUTATIONAL BIOLOGY AND CHEMISTRY文献大全
  • A non toxic natural food colorant and antioxidant 'Peonidin' as a pH indicator: A TDDFT analysis.

    abstract：:A computational inestigation on the difference in colors of two plants 'Peony' and 'Morning glory' by the same pigment 'Peonidin' has been performed by means of absorption characteristics. Peonidin imparts purple color to the flowers in Peony and blue to that in Morning glory. TDDFT tool in Gaussian 09 software packag...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2018.07.015

    authors： Rajan VK,T K SA,C K H,Muraleedharan K

    更新日期：2018-10-01 00:00:00

  • Proteome-wide classification and identification of mammalian-type GPCRs by binary topology pattern.

    abstract：:G protein-coupled receptors (GPCRs), a large eukaryotic protein family, have proved difficult to comprehensively detect and functionally identify by homology searches and domain detection, because they are highly divergent and their sequences share strikingly little similarity. Transmembrane (TM) topology pattern anal...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2003.11.003

    authors： Inoue Y,Ikeda M,Shimizu T

    更新日期：2004-02-01 00:00:00

  • In silico structural and functional analysis of Mesorhizobium ACC deaminase.

    abstract：:Nodulation is one of the very important processes of legume plants as it is the initiating event of fixing nitrogen. Although ethylene has essential role in normal plant metabolism but it has also negative impact on plants particularly in nodule formation in legume plants. It is also produced due to a variety of bioti...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2017.02.005

    authors： Pramanik K,Soren T,Mitra S,Maiti TK

    更新日期：2017-06-01 00:00:00

  • Predicting microRNA biological functions based on genes discriminant analysis.

    abstract：:Although thousands of microRNAs (miRNAs) have been identified in recent experimental efforts, it remains a challenge to explore their specific biological functions through molecular biological experiments. Since those members from same family share same or similar biological functions, classifying new miRNAs into thei...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2017.09.008

    authors： Ding T,Xu J,Sun M,Zhu S,Gao J

    更新日期：2017-12-01 00:00:00

  • Dynamics of p53 and Wnt cross talk.

    abstract：:We present the mechanism of interaction of Wnt network module, which is responsible for periodic somitogenesis, with p53 regulatory network, which is one of the main regulators of various cellular functions, and switching of various oscillating states by investigating p53-Wnt model. The variation in Nutlin concentrati...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2015.07.014

    authors： Zubbair Malik M,Ali S,Alam MJ,Ishrat R,Brojen Singh RK

    更新日期：2015-12-01 00:00:00

  • Interaction of small molecules with the SARS-CoV-2 main protease in silico and in vitro validation of potential lead compounds using an enzyme-linked immunosorbent assay.

    abstract：:Caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the COVID-19 pandemic is ongoing, with no proven safe and effective vaccine to date. Further, effective therapeutic agents for COVID-19 are limited, and as a result, the identification of potential small molecule antiviral drugs is of particul...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2020.107408

    authors： Pitsillou E,Liang J,Karagiannis C,Ververis K,Darmawan KK,Ng K,Hung A,Karagiannis TC

    更新日期：2020-12-01 00:00:00

  • Chromatographic and computational screening of anisotropic lipophilicity and pharmacokinetics of newly synthesized 1-aryl-3-ethyl-3-methylsuccinimides.

    abstract：:The present study is focused on a series of newly synthesized 1-aryl-3-ethyl-3-methylsuccinimide derivatives, as potential anticonvulsants. The retention behavior of eleven succinimide derivatives was determined by using reversed phase high performance liquid chromatography (RP-HPLC) and reversed phase high performanc...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2019.107161

    authors： Kovačević S,Banjac MK,Podunavac-Kuzmanović S,Milošević N,Ćurčić J,Vulić J,Šeregelj V,Banjac N,Ušćumlić G

    更新日期：2020-02-01 00:00:00

  • Genome-wide analysis of the MADS-Box gene family in Chrysanthemum.

    abstract：:MADS-box family transcription factors play key roles in various developmental processes in plants. Here, we identified 108 MADS-box genes in the genome of chrysanthemum (Chrysanthemum nankingense). We classified these genes based on their phylogenetic relationships with MADS-box genes in Arabidopsis thaliana and lettu...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2020.107424

    authors： Won SY,Jung JA,Kim JS

    更新日期：2020-12-05 00:00:00

  • Potential protein biomarkers for systemic lupus erythematosus determined by bioinformatics analysis.

    abstract：:Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disorder, and its pathogenesis in males and in cases without accompanying lupus nephritis (LN-) is not fully understood. In this study, we identified 90 (82 up- and 8 downregulated) differentially expressed genes (DEGs) common to female LN-, female LN+ a...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2019.107135

    authors： Kong J,Li L,Zhimin L,Yan J,Ji D,Chen Y,Yuanyuan W,Chen X,Shao H,Wang J,Da Z

    更新日期：2019-12-01 00:00:00

  • The effect of structure on improvement of the PNA Young modulus: A study of steered molecular dynamics.

    abstract：:Prefoldin is a molecular chaperone and acts as a nano-actuator in cargo carriage and drug delivery for disease treatment. Investigating the mechanical properties of nano-actuator helps predict its behavior and measure its performance under various environmental conditions, like external forces that are applied. Accord...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2019.107133

    authors： Ghasemi RH,Keramati M,Mojarrad MHS

    更新日期：2019-12-01 00:00:00

  • CAMWI: Detecting protein complexes using weighted clustering coefficient and weighted density.

    abstract：:Detection of protein complexes is very important to understand the principles of cellular organization and function. Recently, large protein-protein interactions (PPIs) networks have become available using high-throughput experimental techniques. These networks make it possible to develop computational methods for pro...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2015.07.012

    authors： Lakizadeh A,Jalili S,Marashi SA

    更新日期：2015-10-01 00:00:00

  • Anti-haemostatic compounds from the vampire snail Cumia reticulata: Molecular cloning and in-silico structure-function analysis.

    abstract：:Blood-feeding animals are known for their ability to produce bioactive compounds to impair haemostasis and suppress pain perception in the host. These compounds are extremely appealing for pharmacological development since they are generally very effective and specific for their molecular target. A preliminary RNA-Seq...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2018.05.014

    authors： Modica MV,Reinoso Sánchez J,Pasquadibisceglie A,Oliverio M,Mariottini P,Cervelli M

    更新日期：2018-08-01 00:00:00

  • Genome-wide predicting disease-related protein complexes by walking on the heterogeneous network based on data integration and laplacian normalization.

    abstract：BACKGROUND:Associating protein complexes to human inherited diseases is critical for better understanding of biological processes and functional mechanisms of the disease. Many protein complexes have been identified and functionally annotated by computational and purification methods so far, however, the particular rol...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2017.04.007

    authors： Liu Z,Luo J

    更新日期：2017-08-01 00:00:00

  • Profiling of molecular pathways regulated by microRNA 601.

    abstract：:MicroRNAs (miRNAs) have been implicated in complex vertebrate developmental and pathological systems as a versatile class of molecules involved in the regulation of various biological processes and molecular pathways. To elucidate the role of miRNAs in human somatic cells, an understanding of the molecular framework r...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2009.09.003

    authors： Ohdaira H,Nakagawa H,Yoshida K

    更新日期：2009-12-01 00:00:00

  • Spectroscopic, quantum computational and molecular docking studies on 1-phenylcyclopentane carboxylic acid.

    abstract：:The vibrational wavenumbers of optimized molecular structure of 1-phenylcyclopentane carboxylic acid (1PCPCA) molecule have been calculated by quantum chemical theory and compared with experimental results. The density functional theory (DFT) approach is followed using the method B3LYP and 6-311++G(d,p) basis set. Usi...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2019.05.011

    authors： Raajaraman BR,Sheela NR,Muthu S

    更新日期：2019-10-01 00:00:00

  • Computational binding study of cardiac troponin I antibody towards cardiac versus skeletal troponin I.

    abstract：:A computational study of the interaction of cardiac troponin I (cTnI) with its specific antibody and of that antibody with skeletal troponin I (sTnI), the principal interferon of cTnI, is carried out. Computational and simulation tools such as FTSite, FTMap, FTDock and pyDock are used to determine the binding sites of...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2019.04.002

    authors： Sabek J,Martínez-Pérez P,García-Rupérez J

    更新日期：2019-06-01 00:00:00

  • AROHap: An effective algorithm for single individual haplotype reconstruction based on asexual reproduction optimization.

    abstract：:In this paper, a method for single individual haplotype (SIH) reconstruction using Asexual reproduction optimization (ARO) is proposed. Haplotypes, as a set of genetic variations in each chromosome, contain vital information such as the relationship between human genome and diseases. Finding haplotypes in diploid orga...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2017.12.005

    authors： Olyaee MH,Khanteymoori A

    更新日期：2018-02-01 00:00:00

  • The complex task of choosing a de novo assembly: lessons from fungal genomes.

    abstract：:Selecting the values of parameters used by de novo genomic assembly programs, or choosing an optimal de novo assembly from several runs obtained with different parameters or programs, are tasks that can require complex decision-making. A key parameter that must be supplied to typical next generation sequencing (NGS) a...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2014.08.014

    authors： Gallo JE,Muñoz JF,Misas E,McEwen JG,Clay OK

    更新日期：2014-12-01 00:00:00

  • Reprint of "Abstraction for data integration: Fusing mammalian molecular, cellular and phenotype big datasets for better knowledge extraction".

    abstract：:With advances in genomics, transcriptomics, metabolomics and proteomics, and more expansive electronic clinical record monitoring, as well as advances in computation, we have entered the Big Data era in biomedical research. Data gathering is growing rapidly while only a small fraction of this data is converted to usef...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章,评审

    doi：10.1016/j.compbiolchem.2015.08.005

    authors： Rouillard AD,Wang Z,Ma'ayan A

    更新日期：2015-12-01 00:00:00

  • A novel k-word relative measure for sequence comparison.

    abstract：:In order to extract phylogenetic information from DNA sequences, the new normalized k-word average relative distance is proposed in this paper. The proposed measure was tested by discriminate analysis and phylogenetic analysis. The phylogenetic trees based on the Manhattan distance measure are reconstructed with k ran...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2014.10.007

    authors： Tang J,Hua K,Chen M,Zhang R,Xie X

    更新日期：2014-12-01 00:00:00

  • Complex phylogenetic profiling reveals fundamental genotype-phenotype associations.

    abstract：:We have developed a computational technique refereed to as complex phylogenetic profiling. Our approach combines logic analyses of gene phylogenetic profiles and phenotype data. Logic analysis of phylogenetic profiles identifies sets of proteins whose presence or absence follows certain logic relationships. Our approa...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2008.07.003

    authors： Antonov AV,Mewes HW

    更新日期：2008-12-01 00:00:00

  • A vibrational entropy term for DNA docking with autodock.

    abstract：:DNA interacts with small molecules, from water to endogenous reactive oxygen and nitrogen species, environmental mutagens and carcinogens, and pharmaceutical anticancer molecules. Understanding and predicting the physical interactions of small molecules with DNA via docking is key not only for the comprehension of mol...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2018.03.027

    authors： McElfresh GW,Deligkaris C

    更新日期：2018-06-01 00:00:00

  • Theoretical study of copper binding to GHK peptide.

    abstract：:We report ligand field molecular mechanics, density functional theory and semi-empirical studies on the binding of Cu(II) to GlyHisLys (GHK) peptide. Following exhaustive conformational searching using molecular mechanics, we show that relative energy and geometry of conformations are in good agreement between GFN2-xT...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2020.107265

    authors： Alshammari N,Platts JA

    更新日期：2020-06-01 00:00:00

  • Statistical models in assessing fold change of gene expression in real-time RT-PCR experiments.

    abstract：:Real-time RT-PCR has been frequently used in quantitative research in molecular biology and bioinformatics. It provides remarkably useful technology to assess expression of genes. Although mathematical models for gene amplification process have been studied, statistical models and methods for data analysis in real-tim...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2005.10.005

    authors： Fu WJ,Hu J,Spencer T,Carroll R,Wu G

    更新日期：2006-02-01 00:00:00

  • On application of directons to functional classification of genes in prokaryotes.

    abstract：:Functional classification of genes represents one of the most basic problems in genome analysis and annotation. Our analysis of some of the popular methods for functional classification of genes shows that these methods are not always consistent with each other and may not be specific enough for high-resolution gene f...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2008.02.007

    authors： Wu H,Mao F,Olman V,Xu Y

    更新日期：2008-06-01 00:00:00

  • Multi-group cancer outlier differential gene expression detection.

    abstract：:It has recently been shown that cancer genes (oncogenes) tend to have heterogeneous expressions across disease samples. So it is reasonable to assume that in a microarray data only a subset of disease samples will be activated (often referred to as outliers), which presents some new challenges for statistical analysis...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2007.02.004

    authors： Liu F,Wu B

    更新日期：2007-04-01 00:00:00

  • Drug-target interaction prediction by integrating multiview network data.

    abstract：:Drug-target interaction (DTI) prediction is a challenging step in further drug repositioning, drug discovery and drug design. The advent of high-throughput technologies brings convenience to the development of DTI prediction methods. With the generation of a high number of data sets, many mathematical models and compu...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2017.03.011

    authors： Zhang X,Li L,Ng MK,Zhang S

    更新日期：2017-08-01 00:00:00

  • Automated prediction of three-way junction topological families in RNA secondary structures.

    abstract：:We present an algorithm for automatically predicting the topological family of any RNA three-way junction, given only the information from the secondary structure: the sequence and the Watson-Crick pairings. The parameters of the algorithm have been determined on a data set of 33 three-way junctions whose 3D conformat...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2011.11.001

    authors： Lamiable A,Barth D,Denise A,Quessette F,Vial S,Westhof E

    更新日期：2012-04-01 00:00:00

  • Pharmacoinformatics exploration of polyphenol oxidases leading to novel inhibitors by virtual screening and molecular dynamic simulation study.

    abstract：:Polyphenol oxidases (PPOs)/tyrosinases are metal-dependent enzymes and known as important targets for melanogenesis. Although considerable attempts have been conducted to control the melanin-associated diseases by using various inhibitors. However, the exploration of the best anti-melanin inhibitor without side effect...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2017.02.012

    authors： Hassan M,Abbas Q,Ashraf Z,Moustafa AA,Seo SY

    更新日期：2017-06-01 00:00:00

  • In silico study of porphyrin-anthraquinone hybrids as CDK2 inhibitor.

    abstract：:Cyclin-Dependent Kinases (CDKs) are known to play crucial roles in controlling cell cycle progression of eukaryotic cell and inhibition of their activity has long been considered as potential strategy in anti-cancer drug research. In the present work, a series of porphyrin-anthraquinone hybrids bearing meso-substituen...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2016.12.005

    authors： Arba M,Ihsan S,Ramadhan OA,Tjahjono DH

    更新日期：2017-04-01 00:00:00