Abstract:
:Two patients underwent allogeneic hematopoietic stem cell transplantation (HSCT) for acute myeloid leukemia. Chronic graft-versus-host disease (GVHD) developed, with persistent symptomatic oral lesions. At 2 and 6 years post-HSCT, both patients developed squamous cell carcinoma (SCC) of the tongue in areas previously involved by chronic GVHD. None had any known risk factor for SCC. Histologically, moderate to severe dysplasia was present in noncancerous oral mucosa. Oral SCC is rarely described after HSCT, and a review of the reported cases showed chronic GVHD to be a common risk, suggesting that the chronic inflammation associated with GVHD might be of pathogenetic significance.
journal_name
Am J Hematoljournal_title
American journal of hematologyauthors
Szeto CH,Shek TW,Lie AK,Au WY,Yuen AP,Kwong YLdoi
10.1002/ajh.20160keywords:
subject
Has Abstractpub_date
2004-10-01 00:00:00pages
200-2issue
2eissn
0361-8609issn
1096-8652journal_volume
77pub_type
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