Preferential production of latent transforming growth factor beta-2 by primary prostatic epithelial cells and its activation by prostate-specific antigen.

abstract：:Increasing evidence has demonstrated that abnormal expression of lncRNA is correlated with various malignant tumors, including hepatocellular carcinoma (HCC). Our current study was aimed to investigate the role of LINC00707 in HCC development. We observed that LINC00707 was upregulated in HCC cell lines compared with ...

journal_title：Journal of cellular physiology

authors： Wang J,Luo Z,Yao T,Li W,Pu J

更新日期：2019-05-01 00:00:00

abstract：:In fertilized echinoderm eggs, the male and female pronuclei fuse to form the diploid nucleus even in the presence of aphidicolin, a specific inhibitor of eukaryotic DNA polymerase-alpha. The subsequent first cleavage is independent of chromosomes but dependent on spindle and amphiaster. The fate of DNA originally exi...

journal_title：Journal of cellular physiology

authors： Yamada H,Hirai S,Ikegami S,Kawarada Y,Okuhara E,Nagano H

更新日期：1985-07-01 00:00:00

abstract：:We determined the synthesis and secretion of glycosaminoglycans by three distinct preparations of mouse cultured thymic epithelial cells. These comprised primary cultures of thymic nurse cells (TNCs), which are normally located within the cortex of the thymic lobules, as well as two murine thymic epithelial cells, bea...

journal_title：Journal of cellular physiology

authors： Werneck CC,Cruz MS,Silva LC,Villa-Verde DM,Savino W,Mourão PA

更新日期：2000-10-01 00:00:00

abstract：:alpha-Crystallins share structural and functional properties with the stress protein hsp27. These polypeptides are expressed at low constitutive levels in many tissues including brain, and alpha B-crystallin and hsp27 can accumulate in central nervous system glia in a variety of neurological conditions. We report here...

journal_title：Journal of cellular physiology

authors： Head MW,Corbin E,Goldman JE

更新日期：1994-04-01 00:00:00

abstract：:Normal FBAE AG 7680 cells and chemically transformed FBAE GM 7373 cells were compared for their capacity to produce and to respond to bFGF. Normal FBAE cells showed higher levels of bFGF protein and of poly(A)+ bFGF mRNA than transformed GM 7373 cells, indicating that chemical transformation in FBAE cells is parallele...

journal_title：Journal of cellular physiology

authors： Presta M,Maier JA,Rusnati M,Ragnotti G

更新日期：1989-12-01 00:00:00

abstract：:NGF appears to be involved in spermatogenesis. However, mice lacking NGF or TrkA genes do not survive more than a few days whereas p75(NTR) knockout mice are viable and fertile. Therefore, we addressed the effect of betaNGF on spermatogenesis by using the systems of rat germ cell culture we established previously. bet...

journal_title：Journal of cellular physiology

authors： Perrard MH,Vigier M,Damestoy A,Chapat C,Silandre D,Rudkin BB,Durand P

更新日期：2007-01-01 00:00:00

abstract：:Although the type 1 insulin-like growth factor receptor (IGF-IR) is a potent inhibitor of apoptosis, its C-terminus sequence sends contradictory signals, including a clearly proapoptotic signal. We have synthesized a peptide, peptide 2, having the sequence of the IGF-IR from residue 1282 to residue 1298 (C-terminus of...

journal_title：Journal of cellular physiology

authors： Reiss K,Yumet G,Shan S,Huang Z,Alnemri E,Srinivasula SM,Wang JY,Morrione A,Baserga R

更新日期：1999-10-01 00:00:00

abstract：:We have described recently that expression of CD44 exon v10 (CD44v10) is down-regulated upon metastasis of squamous cell carcinoma, whereas it is up-regulated in skin metastases of malignant melanoma. The striking regulation of CD44v10 prompted us to generate a murine CD44v10-specific monoclonal antibody to define exp...

journal_title：Journal of cellular physiology

authors： Rösel M,Seiter S,Zöller M

更新日期：1997-06-01 00:00:00

abstract：:The metabolome is a data-rich source of information concerning all the low-molecular-weight metabolites in a biofluid, which can indicate early biological changes to the host due to perturbations in metabolic pathways. Major changes can be seen after minor stimuli, which make it a valuable target for analysis. Due to ...

journal_title：Journal of cellular physiology

authors： Johnson CH,Gonzalez FJ

更新日期：2012-08-01 00:00:00

abstract：:Growing evidence has shown that pulsed electromagnetic fields (PEMF) can modulate bone metabolism in vivo and regulate the activities of osteoblasts and osteoclasts in vitro. Osteocytes, accounting for 95% of bone cells, act as the major mechanosensors in bone for transducing external mechanical signals and producing ...

journal_title：Journal of cellular physiology

authors： Wang P,Tang C,Wu J,Yang Y,Yan Z,Liu X,Shao X,Zhai M,Gao J,Liang S,Luo E,Jing D

更新日期：2019-07-01 00:00:00

abstract：:Acidic fibroblast growth factor (aFGF) mRNA was detected in a rat mammary fibroblastic cell line, but not in rat mammary epithelial cell lines or myoepithelial-like cell lines. Basic FGF (bFGF) mRNA was detected in both the fibroblasts and the myoepithelial-like cells, but was absent from the epithelial cells. A serie...

journal_title：Journal of cellular physiology

authors： Barraclough R,Fernig DG,Rudland PS,Smith JA

更新日期：1990-08-01 00:00:00

abstract：:Sepsis is a severe clinical disease, which is resulted from the excessive host inflammation response to the infection. Growing evidence indicates that Staphylococcus aureus pneumonia is a significant cause of sepsis, which can lead to intestinal injury, inflammation, and apoptosis. Studies have shown that miR-182-5p c...

journal_title：Journal of cellular physiology

authors： Du X,Wei J,Tian D,Wu M,Yan C,Hu P,Wu X,Yang W,Yin T

更新日期：2020-01-01 00:00:00

abstract：:Numerous studies have suggested that urothelial cancer-associated 1 (UCA1) acts as a suppressor gene affecting cell proliferation and migration. However, the biological role and the potential mechanism of UCA1 in the progression of pre-eclampsia (PE) remains unclear. The UCA1 level was markedly upregulated in PE pregn...

journal_title：Journal of cellular physiology

authors： Liu J,Luo C,Zhang C,Cai Q,Lin J,Zhu T,Huang X

更新日期：2020-10-01 00:00:00

abstract：:The level of adhesion molecules expressed at the endothelial cell surface is critical in the control of inflammation. Adenylate cyclase (AC) activity allowing cyclic adenosine monophosphate (cAMP) production can modulate the inflammatory process. We investigated the AC-dependent modulation of ICAM-1 surface expression...

journal_title：Journal of cellular physiology

authors： Bernot D,Peiretti F,Canault M,Juhan-Vague I,Nalbone G

更新日期：2005-02-01 00:00:00

abstract：:It is presently unclear what role elevations in intracellular calcium concentration ([Ca2+]i) play in the control of monokine secretion, or whether such alterations underlie the ability of physiologic stimuli to induce production of these important signalling molecules. To address these issues, we have performed exper...

journal_title：Journal of cellular physiology

authors： Marriott I,Bost KL,Mason MJ

更新日期：1998-11-01 00:00:00

abstract：:We have shown in the present study and in studies reported previously that preneoplastic and neoplastic rat tracheal epithelial (RTE) cell lines express TGF alpha and do so regardless of the mechanism by which they were transformed. In order to determine whether TGF alpha is an autocrine growth regulator of immortaliz...

journal_title：Journal of cellular physiology

authors： Ferriola PC,Earp HS,Di Augustine R,Nettesheim P

更新日期：1991-04-01 00:00:00

abstract：:Drug discovery is an onerous, extremely expensive, and time-consuming process. Instead, drug repurposing is an attractive strategy for exploiting novel indications for a drug beyond its original use. The untapped potential of drug repurposing compensates the barriers associated with the drug discovery pipeline. Psoria...

journal_title：Journal of cellular physiology

authors： Thatikonda S,Pooladanda V,Godugu C

更新日期：2020-06-01 00:00:00

abstract：:Nerve-evoked contractile activity in skeletal muscle regulates transcript and protein levels of many metabolic genes in a coordinate fashion, including the muscle isozyme of glycogen phosphorylase (MGP). Cellular signaling mechanisms mediating the activity-dependent modulation of MGP transcript levels were investigate...

journal_title：Journal of cellular physiology

authors： Vali S,Carlsen R,Pessah I,Gorin F

更新日期：2000-11-01 00:00:00

abstract：:Subcellular localization of the large multicatalytic protease complexes called proteasomes, which have been found in soluble fractions of various cells, was examined by biochemical, immunological, and immunohistological methods. Rat liver nuclei, purified by two different procedures, showed high activities for degradi...

journal_title：Journal of cellular physiology

authors： Tanaka K,Kumatori A,Ii K,Ichihara A

更新日期：1989-04-01 00:00:00

abstract：:Testicular germ cell tumors (TGCTs) are frequent solid malignant tumors and cause of death in men between 20-40 years of age. Genetic and environmental factors play an important role in the origin and development of TGCTs. Although the majority of TGCTs are responsive to chemotherapy, about 20% of patient presents inc...

journal_title：Journal of cellular physiology

authors： Chieffi P

更新日期：2017-02-01 00:00:00

abstract：:Mice of the C3H/HeJ strain exhibit low inflammatory and immunological responses to certain bacterial lipopolysaccharide (LPS) preparations. Lymphocytes from C3H/HeJ mice also show defective LPS-induced mitogenesis. We tested the colony stimulating activity (CSA) response of C3H/HeJ mice. As controls we used mice of th...

journal_title：Journal of cellular physiology

authors： Russo M,Lutton JD

更新日期：1977-08-01 00:00:00

abstract：:The matricellular protein periostin is strongly expressed in collagen-rich connective tissues such as periodontal ligaments (PDLs), skeletal muscle, adipose tissue, tendons, skin, and bone. It is prominent in tumorigenesis, angiogenesis, and cardiac repair. It is localized in the periosteum and PDL, where it is seen i...

journal_title：Journal of cellular physiology

authors： Romanos GE,Asnani KP,Hingorani D,Deshmukh VL

更新日期：2014-01-01 00:00:00

abstract：:In certain epithelial tissues, activation of transient receptor potential (TRP) vanilloid subtype 1 (TRPV1) by noxious stimuli induces pro-inflammatory cytokine release, which helps to mitigate the challenge. While the corneal epithelium elicits such responses to a variety of challenges, it remains unknown whether TRP...

journal_title：Journal of cellular physiology

authors： Zhang F,Yang H,Wang Z,Mergler S,Liu H,Kawakita T,Tachado SD,Pan Z,Capó-Aponte JE,Pleyer U,Koziel H,Kao WW,Reinach PS

更新日期：2007-12-01 00:00:00

abstract：:In order to promote cell attachment, fibronectin must first undergo activation by a suitable substrate. In this study, 52 materials have been surveyed for their ability a) to bind fibronectin, b) to activate the cell-adhesive property of fibronectin, and c) to support the growth of cells. Many plastics, polysaccharide...

journal_title：Journal of cellular physiology

authors： Klebe RJ,Bentley KL,Schoen RC

更新日期：1981-12-01 00:00:00

abstract：:Curcumin is known to be a potent wound healer. Despite this, studies on curcumin using certain model systems have shown it to be anti-angiogenic. Results of the present investigations suggest that curcumin causes opposing effects on angiogenesis in serum stimulated and unstimulated conditions. The evidence in support ...

journal_title：Journal of cellular physiology

authors： Kiran MS,Kumar VB,Viji RI,Sherin GT,Rajasekharan KN,Sudhakaran PR

更新日期：2008-04-01 00:00:00

abstract：:The mechanism(s) by which heparin influences the biological activities of acidic and basic fibroblast growth factors (aFGF and bFGF) is not completely understood. One mechanism by which heparin could alter the biological activities of aFGF and bFGF is by altering their biological half-lives. We investigated the possib...

journal_title：Journal of cellular physiology

authors： Damon DH,Lobb RR,D'Amore PA,Wagner JA

更新日期：1989-02-01 00:00:00

abstract：:Human peripheral blood monocytes and neutrophils secrete TGF-beta. Activation of monocytes with LPS stimulates the secretion of TGF-beta; however, the production of TGF-beta by neutrophils was not altered by treatment with LPS. The secreted TGF-beta appears to be in a fully active form since acid treatment of the cond...

journal_title：Journal of cellular physiology

authors： Grotendorst GR,Smale G,Pencev D

更新日期：1989-08-01 00:00:00

abstract：:Sepsis, a complex and dynamic syndrome resulting from microbial invasion and immune system dysregulation, is associated with an increased mortality, reaching up to 35% worldwide. Cholesterol metabolism is often disturbed during sepsis, with low plasma cholesterol levels being associated with poor prognosis. Proprotein...

journal_title：Journal of cellular physiology

authors： Paciullo F,Fallarino F,Bianconi V,Mannarino MR,Sahebkar A,Pirro M

更新日期：2017-09-01 00:00:00

abstract：:Impaired cardiac control of intracellular diastolic Ca(2+) gives rise to arrhythmias. Whereas exercise training corrects abnormal cyclic Ca(2+) handling in heart failure, the effect on diastolic Ca(2+) remains unstudied. Here, we studied the effect of exercise training on the generation and propagation of spontaneous ...

journal_title：Journal of cellular physiology

authors： Kemi OJ,MacQuaide N,Hoydal MA,Ellingsen O,Smith GL,Wisloff U

更新日期：2012-01-01 00:00:00

abstract：:Secretory leukocyte protease inhibitor (SLPI) is a serine protease inhibitor that was related to cancer development and metastasis dissemination on several types of tumors. However, it is not known the effect of SLPI on mammary and colon tumors. The aim of this study was to examine the effect of SLPI on mammary and co...

journal_title：Journal of cellular physiology

authors： Amiano NO,Costa MJ,Reiteri RM,Payés C,Guerrieri D,Tateosian NL,Sánchez ML,Maffia PC,Diament M,Karas R,Orqueda A,Rizzo M,Alaniz L,Mazzolini G,Klein S,Sallenave JM,Chuluyan HE

更新日期：2013-02-01 00:00:00