Abstract:
OBJECTIVE:Cervical spinal cord stimulation (SCS) augments cerebral blood flow (CBF) in a number of animal models. The mechanisms underlying the cerebrovascular effects of SCS are not yet well delineated. In this study, we analyzed two alternative pathways in CBF alterations induced by SCS in rats, one involving direct modulation of sympathetic outflow and the other through central vasomotor influence. METHODS:Resection of the superior cervical ganglion (SCG), SCS alone, or SCS after SCG removal was performed in adult male Sprague-Dawley rats. CBF was measured with (14)C-inosine monophosphate radiotracer studies. In another set of experiments, SCS was performed after spinalization at the cervicomedullary junction or after laminectomy alone. RESULTS:Baseline CBF in the SCG removal group was 71 +/- 8 ml/100 g/min, similar to controls. SCS alone significantly increased blood flow to 100 +/- 10 ml/100 g/min (P < 0.05). Animals that underwent SCS after SCG removal demonstrated a similar robust augmentation in CBF. SCS-induced changes in CBF were completely attenuated by spinalization. CONCLUSION:The profound effects of spinal cord transection on SCS-induced CBF augmentation, together with the lack of effect of surgical sympathectomy, suggest that the mechanisms underlying the effects of SCS involve central influences rather than cervical sympathetic outflow. These findings suggest a possible role for brainstem vasomotor centers in the cerebrovascular effects of SCS.
journal_name
Neurosurgeryjournal_title
Neurosurgeryauthors
Patel S,Huang DL,Sagher Odoi
10.1227/01.neu.0000126949.28912.71keywords:
subject
Has Abstractpub_date
2004-07-01 00:00:00pages
201-6; discussion 206issue
1eissn
0148-396Xissn
1524-4040journal_volume
55pub_type
杂志文章相关文献
NEUROSURGERY文献大全abstract::Excessive mechanical stress on the intervertebral disc may be one of the causes of low back pain. Most studies testing this thesis, however, have been based on quantification of the mechanical response of functional units at failure. Typically, radiography is used to demonstrate trauma to the vertebral body at the fai...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198808000-00006
更新日期:1988-08-01 00:00:00
abstract::An extremely rare case of a basioccipital meningocele causing obstruction of the upper airway in a neonate is described. A transoral approach was used to remove the meningocele and repair the dural fistula. Bilateral posterior lateral pharyngeal releasing incisions were made to allow mucosal and muscle coverage over t...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-198909000-00027
更新日期:1989-09-01 00:00:00
abstract:BACKGROUND AND IMPORTANCE:As the use of flow-diverting stents (FDSs) for intracranial aneurysms expands, a small number of case reports have described the successful treatment of blister aneurysms of the internal carotid artery with flow diversion. Blister aneurysms are uncommon and fragile lesions that historically ha...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0000000000001412
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Distal junctional kyphosis (DJK) development after cervical deformity (CD)-corrective surgery is a growing concern for surgeons and patients. Few studies have investigated risk factors that predict the occurrence of DJK. OBJECTIVE:To predict DJK development after CD surgery using predictive modeling. METHO...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyz347
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Although originally isolated from the bone marrow, mesenchymal stem cells (MSCs) have recently been detected in other tissues. However, little is known about MSCs in the brain. OBJECTIVE:To determine the extent to which cells with the features of MSCs exist in normal brain tissue and to determine the locati...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000377859.06219.78
更新日期:2010-09-01 00:00:00
abstract::From December 1981 through August 1984, 24 patients with spinal cord compression syndrome due to epidural neoplasms were evaluated for radiotherapy with clinical examination, radiographs of the spine, and myelography. All plain films were reviewed, and mock radiotherapy fields designed using specific criteria for marg...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198610000-00018
更新日期:1986-10-01 00:00:00
abstract::In three cases involving meningiomas in the ethmoid and sphenoid sinuses, transbasal spreading of the interocular distance (telecanthal approach) was used for tumor removal and reconstruction of the skull base. This telecanthal approach involves 1) bilateral en bloc removal of the superior lateral rim of the orbit, th...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1097/00006123-199105000-00013
更新日期:1991-05-01 00:00:00
abstract::Animal bite is a common cause of craniofacial injuries in children. Whereas scalp lacerations from animal bites are often extensive and severe, only four instances of compound depressed skull fractures from animal bites have been reported. A case of a dog bite to the head of an infant is presented to point out the pot...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198110000-00015
更新日期:1981-10-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:Capillary telangiectasias, cavernous malformations, and developmental venous anomalies are all vascular malformations that occur on the capillary-venous side of the cerebral circulation. The associations of capillary telangiectasias with venous malformations, cavernous malformations with venous...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200111000-00044
更新日期:2001-11-01 00:00:00
abstract::Invading glioma cells seem to follow distinct anatomic structures within the central nervous system. Tumor cell dissemination may occur along structures, such as the basement membranes of blood vessels or the glial limitans externa, that contain extracellular matrix (ECM) proteins. Frequently, invasive glioma cells ar...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1097/00006123-199608000-00001
更新日期:1996-08-01 00:00:00
abstract:Background and importance:Pilocytic astrocytoma (PA) is among the most common of the central nervous system gliomas in the pediatric population; however, it is uncommon in adults. PAs of the spinal cord in adults are even rarer, with only a few cases found in the literature. We report here the first case in the literat...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1093/neuros/nyw029
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Extent of resection (EOR) correlates with glioblastoma outcomes. Resectability and EOR depend on anatomical, clinical, and surgeon factors. Resectability likely influences outcome in and of itself, but an accurate measurement of resectability remains elusive. An understanding of resectability and the factors...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0000000000001374
更新日期:2017-04-01 00:00:00
abstract::A case of cerebellopontine angle petrous bone osteoma manifesting as homolateral trigeminal neuralgia and causing a mild brain stem compression is presented. The literature concerning osteomas and particularly those affecting the temporal bone is reviewed. This is the second report of an osteoma located on the inner s...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1227/00006123-199412000-00018
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND:Spinal cord dose limits are critically important for the safe practice of spine stereotactic body radiotherapy (SBRT). However, the effect of inherent spinal cord motion on cord dose in SBRT is unknown. OBJECTIVE:To assess the effects of cord motion on spinal cord dose in SBRT. METHODS:Dynamic balanced fas...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyaa202
更新日期:2020-06-04 00:00:00
abstract:BACKGROUND:The use of bone morphogenetic proteins for fusion augmentation in spine surgery has increased dramatically in recent years. Information is continually emerging regarding the effectiveness and safety profile of these compounds. OBJECTIVE:We have noted an increased incidence in sterile seroma formation and pa...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000369517.21018.F2
更新日期:2010-06-01 00:00:00
abstract::Proton magnetic resonance spectroscopic imaging (1H-MRSI) and positron emission tomography with the tracer L-[1-11C]tyrosine (11C-TYR) were used to localize gliomas for biopsy or resection. This is especially helpful in cases of low-grade gliomas, if these lesions are not visualized by contrast-enhanced computed tomog...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-199406000-00007
更新日期:1994-06-01 00:00:00
abstract::In four patients, shunt obstruction was accompanied by severe resting tremor involving principally the head, the jaw, the tongue, and the right upper extremity. Shunt revision resulted in improvement in each patient. Five similar patients have been reported. Although rare, the occurrence of parkinsonian tremor in a pr...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1227/00006123-199509000-00023
更新日期:1995-09-01 00:00:00
abstract::T-lymphocyte subpopulations (Tg or "suppressor cells" and Tm or "helper cells") in the peripheral blood of 16 patients with malignant intracranial gliomas were analyzed. The number of Tm-lymphocytes was very close to normal in both pre- and postoperative samples, whereas Tg-lymphocytes were significantly increased pre...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198205000-00004
更新日期:1982-05-01 00:00:00
abstract:BACKGROUND AND IMPORTANCE:We report an extremely rare case with mirror-site spinal dural arteriovenous fistulas (DAVFs) at the craniocervical junction. Although multiple spinal DAVFs have been reported in the literature, complete mirror-site lesions with fistulas and feeding arteries in the symmetric position have not ...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1227/NEU.0b013e318223bab5
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:Rugby is characterized by high-speed collisions among the players that predispose them to injuries, particularly to the head, neck, and spine. OBJECTIVE:To evaluate the effectiveness of current neurological injury prevention strategies in rugby union. METHODS:Systematic review in May 2010. We assessed the ...
journal_title:Neurosurgery
pub_type: 杂志文章,meta分析,评审
doi:10.1227/NEU.0b013e3181f209f1
更新日期:2010-11-01 00:00:00
abstract::This is the first report of a series of adults (> 16 years of age) with pineoblastomas who had their entire neuraxis staged at the time of diagnosis. Between 1975 and 1992, seven men and four women with histologically proven pineoblastomas were evaluated at the University of California, San Francisco. The median age a...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-199509000-00003
更新日期:1995-09-01 00:00:00
abstract::Extreme lateral disc herniation with compression of the nerve root as it exits through the foramen has been a recognized entity for a number of years. Until recently, this diagnosis was made infrequently except at the time of operation. Reported here are 12 cases of root compression from disc herniation at the level o...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198405000-00004
更新日期:1984-05-01 00:00:00
abstract:BACKGROUND:Markers of coagulation have shown to have important value in predicting traumatic brain injury outcome. OBJECTIVE:To externally validate and investigate the role of markers of coagulation for outcome prediction by using the International Mission for Prognosis and Analysis of Clinical Trials (IMPACT) model w...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000430326.40763.ec
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:Intracranial solitary fibrous tumors have been described previously, but intraventricular solitary fibrous tumors are extremely rare. We present what is, to our knowledge, the first reported case of solitary fibrous tumor in the third ventricle. CLINICAL PRESENTATION:A 63-year-old man presente...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000097555.75899.c3
更新日期:2004-01-01 00:00:00
abstract::The diagnosis of malignant glioma of the optic nerves and chiasm may be difficult because these rare lesions may mimic other suprasellar lesions. We report a case of glioblastoma multiforme of the optic chiasm in which the appearance of the lesion on computed tomographic (CT) scan was consistent with that of craniopha...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198212000-00011
更新日期:1982-12-01 00:00:00
abstract:OBJECTIVE:Multislice computed tomographic angiography (CTA) can provide clearer vascular images, even of the peripheral arteries, than conventional CTA. Multislice CTA was compared with digital subtraction angiography (DSA) for the detection of cerebral vasospasm in patients with acute aneurysmal subarachnoid hemorrhag...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200210000-00015
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:Preoperative diffusion tensor imaging (DTI) is used to demonstrate corticospinal tract (CST) position. Intraoperative brain shifts may limit preoperative DTI value, and studies characterizing such shifts are lacking. OBJECTIVE:To examine tumor characteristics that could predict intraoperative shift in tumor...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0000000000000338
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Temporal lobe arteriovenous malformations (AVMs) represent a subgroup of intracranial AVMs with particular characteristics and management issues. OBJECTIVE:To characterize the surgical outcomes of temporal lobe AVMs with emphasis on visual field deficits (VFDs) and seizures. METHODS:Between 1992 and 2008, ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0000000000000122
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:Cognitive decline occurs in 25% of patients after carotid endarterectomy (CEA). Elevated serum concentrations of S-100B and neuron-specific enolase (NSE) occur after stroke, and serum S-100B levels at 24 hours are associated with clinical outcome after both stroke and CEA. We hypothesized that we could detect...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000093493.16850.11
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND:Though the Pipeline Embolization Device (Medtronic) is approved for use in adults 22 yr and older, the high efficacy and long-term durability of the device is attractive for treatment of intracranial aneurysms in younger patients who often have aneurysms less amenable to traditional endovascular treatments. ...
journal_title:Neurosurgery
pub_type: 杂志文章,多中心研究
doi:10.1093/neuros/nyz380
更新日期:2020-07-01 00:00:00