Evidence for a central pathway in the cerebrovascular effects of spinal cord stimulation.

Abstract:

OBJECTIVE:Cervical spinal cord stimulation (SCS) augments cerebral blood flow (CBF) in a number of animal models. The mechanisms underlying the cerebrovascular effects of SCS are not yet well delineated. In this study, we analyzed two alternative pathways in CBF alterations induced by SCS in rats, one involving direct modulation of sympathetic outflow and the other through central vasomotor influence. METHODS:Resection of the superior cervical ganglion (SCG), SCS alone, or SCS after SCG removal was performed in adult male Sprague-Dawley rats. CBF was measured with (14)C-inosine monophosphate radiotracer studies. In another set of experiments, SCS was performed after spinalization at the cervicomedullary junction or after laminectomy alone. RESULTS:Baseline CBF in the SCG removal group was 71 +/- 8 ml/100 g/min, similar to controls. SCS alone significantly increased blood flow to 100 +/- 10 ml/100 g/min (P < 0.05). Animals that underwent SCS after SCG removal demonstrated a similar robust augmentation in CBF. SCS-induced changes in CBF were completely attenuated by spinalization. CONCLUSION:The profound effects of spinal cord transection on SCS-induced CBF augmentation, together with the lack of effect of surgical sympathectomy, suggest that the mechanisms underlying the effects of SCS involve central influences rather than cervical sympathetic outflow. These findings suggest a possible role for brainstem vasomotor centers in the cerebrovascular effects of SCS.

journal_name

Neurosurgery

journal_title

Neurosurgery

authors

Patel S,Huang DL,Sagher O

doi

10.1227/01.neu.0000126949.28912.71

keywords:

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

201-6; discussion 206

issue

1

eissn

0148-396X

issn

1524-4040

journal_volume

55

pub_type

杂志文章
  • Microtrauma in the lumbar spine: a cause of low back pain.

    abstract::Excessive mechanical stress on the intervertebral disc may be one of the causes of low back pain. Most studies testing this thesis, however, have been based on quantification of the mechanical response of functional units at failure. Typically, radiography is used to demonstrate trauma to the vertebral body at the fai...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198808000-00006

    authors: Yoganandan N,Maiman DJ,Pintar F,Ray G,Myklebust JB,Sances A Jr,Larson SJ

    更新日期:1988-08-01 00:00:00

  • Transoral repair of a rare basioccipital meningocele in a neonate: case report.

    abstract::An extremely rare case of a basioccipital meningocele causing obstruction of the upper airway in a neonate is described. A transoral approach was used to remove the meningocele and repair the dural fistula. Bilateral posterior lateral pharyngeal releasing incisions were made to allow mucosal and muscle coverage over t...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-198909000-00027

    authors: Azizkhan RG,Cuenca RE,Powers SK

    更新日期:1989-09-01 00:00:00

  • Rerupture of a Blister Aneurysm After Treatment With a Single Flow-Diverting Stent.

    abstract:BACKGROUND AND IMPORTANCE:As the use of flow-diverting stents (FDSs) for intracranial aneurysms expands, a small number of case reports have described the successful treatment of blister aneurysms of the internal carotid artery with flow diversion. Blister aneurysms are uncommon and fragile lesions that historically ha...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0000000000001412

    authors: Mazur MD,Taussky P,MacDonald JD,Park MS

    更新日期:2016-11-01 00:00:00

  • Predicting the Occurrence of Postoperative Distal Junctional Kyphosis in Cervical Deformity Patients.

    abstract:BACKGROUND:Distal junctional kyphosis (DJK) development after cervical deformity (CD)-corrective surgery is a growing concern for surgeons and patients. Few studies have investigated risk factors that predict the occurrence of DJK. OBJECTIVE:To predict DJK development after CD surgery using predictive modeling. METHO...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1093/neuros/nyz347

    authors: Passias PG,Horn SR,Oh C,Lafage R,Lafage V,Smith JS,Line B,Protopsaltis TS,Yagi M,Bortz CA,Segreto FA,Alas H,Diebo BG,Sciubba DM,Kelly MP,Daniels AH,Klineberg EO,Burton DC,Hart RA,Schwab FJ,Bess S,Shaffrey CI,A

    更新日期:2020-01-01 00:00:00

  • Isolation and perivascular localization of mesenchymal stem cells from mouse brain.

    abstract:BACKGROUND:Although originally isolated from the bone marrow, mesenchymal stem cells (MSCs) have recently been detected in other tissues. However, little is known about MSCs in the brain. OBJECTIVE:To determine the extent to which cells with the features of MSCs exist in normal brain tissue and to determine the locati...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.NEU.0000377859.06219.78

    authors: Kang SG,Shinojima N,Hossain A,Gumin J,Yong RL,Colman H,Marini F,Andreeff M,Lang FF

    更新日期:2010-09-01 00:00:00

  • Impact of myelography on the radiotherapeutic management of malignant spinal cord compression.

    abstract::From December 1981 through August 1984, 24 patients with spinal cord compression syndrome due to epidural neoplasms were evaluated for radiotherapy with clinical examination, radiographs of the spine, and myelography. All plain films were reviewed, and mock radiotherapy fields designed using specific criteria for marg...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198610000-00018

    authors: Calkins AR,Olson MA,Ellis JH

    更新日期:1986-10-01 00:00:00

  • Telecanthal approach for meningiomas in the ethmoid and sphenoid sinuses.

    abstract::In three cases involving meningiomas in the ethmoid and sphenoid sinuses, transbasal spreading of the interocular distance (telecanthal approach) was used for tumor removal and reconstruction of the skull base. This telecanthal approach involves 1) bilateral en bloc removal of the superior lateral rim of the orbit, th...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1097/00006123-199105000-00013

    authors: Fujitsu K,Saijoh M,Aoki F,Sakata K,Fujii S,Mochimatsu Y,Kuwabara T

    更新日期:1991-05-01 00:00:00

  • Craniocerebral injuries from dog bite in an infant.

    abstract::Animal bite is a common cause of craniofacial injuries in children. Whereas scalp lacerations from animal bites are often extensive and severe, only four instances of compound depressed skull fractures from animal bites have been reported. A case of a dog bite to the head of an infant is presented to point out the pot...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198110000-00015

    authors: Wilberger JE Jr,Pang D

    更新日期:1981-10-01 00:00:00

  • The juxtaposition of a capillary telangiectasia, cavernous malformation, and developmental venous anomaly in the brainstem of a single patient: case report.

    abstract:OBJECTIVE AND IMPORTANCE:Capillary telangiectasias, cavernous malformations, and developmental venous anomalies are all vascular malformations that occur on the capillary-venous side of the cerebral circulation. The associations of capillary telangiectasias with venous malformations, cavernous malformations with venous...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-200111000-00044

    authors: Clatterbuck RE,Elmací I,Rigamonti D

    更新日期:2001-11-01 00:00:00

  • Glioma invasion in the central nervous system.

    abstract::Invading glioma cells seem to follow distinct anatomic structures within the central nervous system. Tumor cell dissemination may occur along structures, such as the basement membranes of blood vessels or the glial limitans externa, that contain extracellular matrix (ECM) proteins. Frequently, invasive glioma cells ar...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1097/00006123-199608000-00001

    authors: Giese A,Westphal M

    更新日期:1996-08-01 00:00:00

  • Multifocal Intradural Extramedullary Pilocytic Astrocytomas of the Spinal Cord: A Case Report and Review of the Literature.

    abstract:Background and importance:Pilocytic astrocytoma (PA) is among the most common of the central nervous system gliomas in the pediatric population; however, it is uncommon in adults. PAs of the spinal cord in adults are even rarer, with only a few cases found in the literature. We report here the first case in the literat...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1093/neuros/nyw029

    authors: Basheer A,Rammo R,Kalkanis S,Felicella MM,Chedid M

    更新日期:2017-02-01 00:00:00

  • Defining Glioblastoma Resectability Through the Wisdom of the Crowd: A Proof-of-Principle Study.

    abstract:BACKGROUND:Extent of resection (EOR) correlates with glioblastoma outcomes. Resectability and EOR depend on anatomical, clinical, and surgeon factors. Resectability likely influences outcome in and of itself, but an accurate measurement of resectability remains elusive. An understanding of resectability and the factors...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0000000000001374

    authors: Sonabend AM,Zacharia BE,Cloney MB,Sonabend A,Showers C,Ebiana V,Nazarian M,Swanson KR,Baldock A,Brem H,Bruce JN,Butler W,Cahill DP,Carter B,Orringer DA,Roberts DW,Sagher O,Sanai N,Schwartz TH,Silbergeld DL,Sisti M

    更新日期:2017-04-01 00:00:00

  • Cerebellopontine angle osteoma causing trigeminal neuralgia: case report.

    abstract::A case of cerebellopontine angle petrous bone osteoma manifesting as homolateral trigeminal neuralgia and causing a mild brain stem compression is presented. The literature concerning osteomas and particularly those affecting the temporal bone is reviewed. This is the second report of an osteoma located on the inner s...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1227/00006123-199412000-00018

    authors: Ruelle A,Datti R,Andrioli G

    更新日期:1994-12-01 00:00:00

  • The Dancing Cord: Inherent Spinal Cord Motion and Its Effect on Cord Dose in Spine Stereotactic Body Radiation Therapy.

    abstract:BACKGROUND:Spinal cord dose limits are critically important for the safe practice of spine stereotactic body radiotherapy (SBRT). However, the effect of inherent spinal cord motion on cord dose in SBRT is unknown. OBJECTIVE:To assess the effects of cord motion on spinal cord dose in SBRT. METHODS:Dynamic balanced fas...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1093/neuros/nyaa202

    authors: Oztek MA,Mayr NA,Mossa-Basha M,Nyflot M,Sponseller PA,Wu W,Hofstetter CP,Saigal R,Bowen SR,Hippe DS,Yuh WTC,Stewart RD,Lo SS

    更新日期:2020-06-04 00:00:00

  • Formation of painful seroma and edema after the use of recombinant human bone morphogenetic protein-2 in posterolateral lumbar spine fusions.

    abstract:BACKGROUND:The use of bone morphogenetic proteins for fusion augmentation in spine surgery has increased dramatically in recent years. Information is continually emerging regarding the effectiveness and safety profile of these compounds. OBJECTIVE:We have noted an increased incidence in sterile seroma formation and pa...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.NEU.0000369517.21018.F2

    authors: Garrett MP,Kakarla UK,Porter RW,Sonntag VK

    更新日期:2010-06-01 00:00:00

  • Contribution of magnetic resonance spectroscopic imaging and L-[1-11C]tyrosine positron emission tomography to localization of cerebral gliomas for biopsy.

    abstract::Proton magnetic resonance spectroscopic imaging (1H-MRSI) and positron emission tomography with the tracer L-[1-11C]tyrosine (11C-TYR) were used to localize gliomas for biopsy or resection. This is especially helpful in cases of low-grade gliomas, if these lesions are not visualized by contrast-enhanced computed tomog...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-199406000-00007

    authors: Go KG,Keuter EJ,Kamman RL,Pruim J,Metzemaekers JD,Staal MJ,Paans AM,Vaalburg W

    更新日期:1994-06-01 00:00:00

  • Tremor as the result of shunt obstruction: four patients with cysticercosis and secondary parkinsonism: report of four cases.

    abstract::In four patients, shunt obstruction was accompanied by severe resting tremor involving principally the head, the jaw, the tongue, and the right upper extremity. Shunt revision resulted in improvement in each patient. Five similar patients have been reported. Although rare, the occurrence of parkinsonian tremor in a pr...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1227/00006123-199509000-00023

    authors: Keane JR

    更新日期:1995-09-01 00:00:00

  • Impaired immunocompetence in patients with malignant gliomas: the possible role of Tg-lymphocyte subpopulations.

    abstract::T-lymphocyte subpopulations (Tg or "suppressor cells" and Tm or "helper cells") in the peripheral blood of 16 patients with malignant intracranial gliomas were analyzed. The number of Tm-lymphocytes was very close to normal in both pre- and postoperative samples, whereas Tg-lymphocytes were significantly increased pre...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198205000-00004

    authors: Gerosa MA,Olivi A,Rosenblum ML,Semenzato GP,Pezzutto A

    更新日期:1982-05-01 00:00:00

  • Mirror-image spinal dural arteriovenous fistulas at the craniocervical junction: case report and review of the literature.

    abstract:BACKGROUND AND IMPORTANCE:We report an extremely rare case with mirror-site spinal dural arteriovenous fistulas (DAVFs) at the craniocervical junction. Although multiple spinal DAVFs have been reported in the literature, complete mirror-site lesions with fistulas and feeding arteries in the symmetric position have not ...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1227/NEU.0b013e318223bab5

    authors: Oshita J,Yamaguchi S,Ohba S,Kurisu K

    更新日期:2011-11-01 00:00:00

  • The effectiveness of interventions to reduce neurological injuries in rugby union: a systematic review.

    abstract:BACKGROUND:Rugby is characterized by high-speed collisions among the players that predispose them to injuries, particularly to the head, neck, and spine. OBJECTIVE:To evaluate the effectiveness of current neurological injury prevention strategies in rugby union. METHODS:Systematic review in May 2010. We assessed the ...

    journal_title:Neurosurgery

    pub_type: 杂志文章,meta分析,评审

    doi:10.1227/NEU.0b013e3181f209f1

    authors: Cusimano MD,Nassiri F,Chang Y

    更新日期:2010-11-01 00:00:00

  • Pineoblastoma in adults.

    abstract::This is the first report of a series of adults (> 16 years of age) with pineoblastomas who had their entire neuraxis staged at the time of diagnosis. Between 1975 and 1992, seven men and four women with histologically proven pineoblastomas were evaluated at the University of California, San Francisco. The median age a...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-199509000-00003

    authors: Chang SM,Lillis-Hearne PK,Larson DA,Wara WM,Bollen AW,Prados MD

    更新日期:1995-09-01 00:00:00

  • Extreme lateral disc herniation: diagnosis by computed tomographic scanning.

    abstract::Extreme lateral disc herniation with compression of the nerve root as it exits through the foramen has been a recognized entity for a number of years. Until recently, this diagnosis was made infrequently except at the time of operation. Reported here are 12 cases of root compression from disc herniation at the level o...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198405000-00004

    authors: Godersky JC,Erickson DL,Seljeskog EL

    更新日期:1984-05-01 00:00:00

  • External validation of the international mission for prognosis and analysis of clinical trials model and the role of markers of coagulation.

    abstract:BACKGROUND:Markers of coagulation have shown to have important value in predicting traumatic brain injury outcome. OBJECTIVE:To externally validate and investigate the role of markers of coagulation for outcome prediction by using the International Mission for Prognosis and Analysis of Clinical Trials (IMPACT) model w...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.neu.0000430326.40763.ec

    authors: Raj R,Siironen J,Kivisaari R,Hernesniemi J,Tanskanen P,Handolin L,Skrifvars MB

    更新日期:2013-08-01 00:00:00

  • Intraventricular solitary fibrous tumor: an unusual tumor with radiological, ultrastructural, and immunohistochemical evaluation: case report.

    abstract:OBJECTIVE AND IMPORTANCE:Intracranial solitary fibrous tumors have been described previously, but intraventricular solitary fibrous tumors are extremely rare. We present what is, to our knowledge, the first reported case of solitary fibrous tumor in the third ventricle. CLINICAL PRESENTATION:A 63-year-old man presente...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.neu.0000097555.75899.c3

    authors: Koçak A,Cayli SR,Saraç K,Aydin NE

    更新日期:2004-01-01 00:00:00

  • Malignant optic glioma presenting radiologically as a "cystic" suprasellar mass: case report and review of the literature.

    abstract::The diagnosis of malignant glioma of the optic nerves and chiasm may be difficult because these rare lesions may mimic other suprasellar lesions. We report a case of glioblastoma multiforme of the optic chiasm in which the appearance of the lesion on computed tomographic (CT) scan was consistent with that of craniopha...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198212000-00011

    authors: Barbaro NM,Rosenblum ML,Maitland CG,Hoyt WF,Davis RL

    更新日期:1982-12-01 00:00:00

  • Evaluation of vasospasm after subarachnoid hemorrhage by use of multislice computed tomographic angiography.

    abstract:OBJECTIVE:Multislice computed tomographic angiography (CTA) can provide clearer vascular images, even of the peripheral arteries, than conventional CTA. Multislice CTA was compared with digital subtraction angiography (DSA) for the detection of cerebral vasospasm in patients with acute aneurysmal subarachnoid hemorrhag...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-200210000-00015

    authors: Otawara Y,Ogasawara K,Ogawa A,Sasaki M,Takahashi K

    更新日期:2002-10-01 00:00:00

  • Preoperative imaging to predict intraoperative changes in tumor-to-corticospinal tract distance: an analysis of 45 cases using high-field intraoperative magnetic resonance imaging.

    abstract:BACKGROUND:Preoperative diffusion tensor imaging (DTI) is used to demonstrate corticospinal tract (CST) position. Intraoperative brain shifts may limit preoperative DTI value, and studies characterizing such shifts are lacking. OBJECTIVE:To examine tumor characteristics that could predict intraoperative shift in tumor...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0000000000000338

    authors: Shahar T,Rozovski U,Marko NF,Tummala S,Ziu M,Weinberg JS,Rao G,Kumar VA,Sawaya R,Prabhu SS

    更新日期:2014-07-01 00:00:00

  • Temporal lobe arteriovenous malformations: surgical outcomes with a focus on visual field defects and epilepsy.

    abstract:BACKGROUND:Temporal lobe arteriovenous malformations (AVMs) represent a subgroup of intracranial AVMs with particular characteristics and management issues. OBJECTIVE:To characterize the surgical outcomes of temporal lobe AVMs with emphasis on visual field deficits (VFDs) and seizures. METHODS:Between 1992 and 2008, ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0000000000000122

    authors: Lopez-Ojeda P,Labib M,Burneo J,Lownie SP

    更新日期:2013-11-01 00:00:00

  • Failure of intraoperative jugular bulb S-100B and neuron-specific enolase sampling to predict cognitive injury after carotid endarterectomy.

    abstract:OBJECTIVE:Cognitive decline occurs in 25% of patients after carotid endarterectomy (CEA). Elevated serum concentrations of S-100B and neuron-specific enolase (NSE) occur after stroke, and serum S-100B levels at 24 hours are associated with clinical outcome after both stroke and CEA. We hypothesized that we could detect...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.neu.0000093493.16850.11

    authors: Sahlein DH,Heyer EJ,Rampersad A,Winfree CJ,Solomon RA,Benvenisty AI,Quest DO,Du E,Connolly ES

    更新日期:2003-12-01 00:00:00

  • Flow Diversion for Treatment of Intracranial Aneurysms in Pediatric Patients: Multicenter Case Series.

    abstract:BACKGROUND:Though the Pipeline Embolization Device (Medtronic) is approved for use in adults 22 yr and older, the high efficacy and long-term durability of the device is attractive for treatment of intracranial aneurysms in younger patients who often have aneurysms less amenable to traditional endovascular treatments. ...

    journal_title:Neurosurgery

    pub_type: 杂志文章,多中心研究

    doi:10.1093/neuros/nyz380

    authors: Cherian J,Srinivasan V,Froehler MT,Grossberg JA,Cawley CM,Hanel RA,Puri A,Dumont T,Ducruet AF,Albuquerque F,Arthur A,Cheema A,Spiotta A,Anadani M,Lopes D,Saied A,Kim L,Kelly CM,Chen PR,Mocco J,De Leacy R,Powers

    更新日期:2020-07-01 00:00:00