Impaired immunocompetence in patients with malignant gliomas: the possible role of Tg-lymphocyte subpopulations.

Abstract:

:T-lymphocyte subpopulations (Tg or "suppressor cells" and Tm or "helper cells") in the peripheral blood of 16 patients with malignant intracranial gliomas were analyzed. The number of Tm-lymphocytes was very close to normal in both pre- and postoperative samples, whereas Tg-lymphocytes were significantly increased preoperatively (18.55 +/- 1.11 vs. 12.72 +/- 1.19 p less than 0.001) and were still slightly higher than normal after operation and radiation treatment. These preliminary findings suggest a possible role of T-suppressor lymphocytes in the impairment of cell-mediated immunocompetence that has been observed repeatedly in patients with malignant gliomas.

journal_name

Neurosurgery

journal_title

Neurosurgery

authors

Gerosa MA,Olivi A,Rosenblum ML,Semenzato GP,Pezzutto A

doi

10.1227/00006123-198205000-00004

subject

Has Abstract

pub_date

1982-05-01 00:00:00

pages

571-3

issue

5

eissn

0148-396X

issn

1524-4040

journal_volume

10

pub_type

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