Abstract:
BACKGROUND:Though the Pipeline Embolization Device (Medtronic) is approved for use in adults 22 yr and older, the high efficacy and long-term durability of the device is attractive for treatment of intracranial aneurysms in younger patients who often have aneurysms less amenable to traditional endovascular treatments. OBJECTIVE:To report technical, angiographic, and clinical outcomes in patients aged 21 or below undergoing flow-diversion treatment for intracranial aneurysms. METHODS:Retrospective review across 16 institutions identified 39 patients aged 21 or below undergoing 46 treatment sessions with Pipeline Embolization Device placement between 2012 and 2018. A total of 50 intracranial aneurysms were treated. Details regarding patient demographics, aneurysm characteristics, treatment considerations, clinical outcomes, and aneurysm occlusion were obtained and analyzed in a multicenter database. RESULTS:A total of 70% of patients were male. Nonsaccular morphology was seen in half of identified aneurysms. Six aneurysms were giant, and five patients were treated acutely after ruptured presentation. Eight patients were younger than 10 yr of age. Complete aneurysm occlusion was seen in 74% of treated aneurysms. Three aneurysms (6%) were retreated. A total of 83% of patients had a modified Rankin Scale scores of ≤2 at last clinical follow-up. There were 2 early mortalities (4.3%) in the immediate postprocedure period because of rerupture of a treated ruptured aneurysm. No recanalization of a previously occluded aneurysm was observed. CONCLUSION:Flow-diversion treatment is a safe and effective treatment for intracranial aneurysms in patients younger than 22 yr. Rates of complete aneurysm occlusion and adverse events are comparable for rates seen in older patients.
journal_name
Neurosurgeryjournal_title
Neurosurgeryauthors
Cherian J,Srinivasan V,Froehler MT,Grossberg JA,Cawley CM,Hanel RA,Puri A,Dumont T,Ducruet AF,Albuquerque F,Arthur A,Cheema A,Spiotta A,Anadani M,Lopes D,Saied A,Kim L,Kelly CM,Chen PR,Mocco J,De Leacy R,Powersdoi
10.1093/neuros/nyz380subject
Has Abstractpub_date
2020-07-01 00:00:00pages
53-62issue
1eissn
0148-396Xissn
1524-4040pii
5574634journal_volume
87pub_type
杂志文章,多中心研究相关文献
NEUROSURGERY文献大全abstract::The spinal form of brucellosis is still a disabling disease in many countries outside North America and northern and central Europe. Fifteen consecutive cases of spinal brucellosis diagnosed and treated over a 20-year period were reviewed retrospectively. Six patients were farmers, while 10 patients had a history of i...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-199311000-00008
更新日期:1993-11-01 00:00:00
abstract::The olfactory function could be examined in 101 of 138 patients with anterior communicating artery aneurysms, whom we treated during a recent 6-year period. Among them, 49 patients underwent surgery by the anterior interhemispheric approach and 52 underwent surgery by the basal interhemispheric approach. Fifteen patie...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199602000-00017
更新日期:1996-02-01 00:00:00
abstract:IMPORTANCE:Rhinocerebral mucormycosis is extremely difficult to treat. Approximately 70% of patients are poorly controlled diabetics, and many of the remainder are immunocompromised as a consequence of cytotoxic drugs, burn injuries, or end-stage renal disease. Despite standard treatment consisting of surgical debridem...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199803000-00037
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND:Spine and nonspine skeletal metastases occur in more than 80% of patients with prostate cancer. OBJECTIVE:To examine the characteristics of the patient population undergoing surgery for the treatment of prostate cancer metastatic to the spine. METHODS:A retrospective chart review was performed on all patie...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyx292
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Patients who survive aneurysmal subarachnoid hemorrhage (aSAH) are at risk for delayed neurological deficits (DND) and cerebral infarction. In this exploratory cohort comparison analysis, we compared in-hospital outcomes of aSAH patients administered a low-dose intravenous heparin (LDIVH) infusion (12 U/kg/h...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyaa473
更新日期:2020-12-02 00:00:00
abstract:OBJECTIVE:Currently, because of the precision of stereotactic radiosurgery, radiation can now be delivered by techniques that shape the radiation beam to the tissue target for a variety of clinical applications. This avoids unnecessary and potentially damaging irradiation of surrounding tissues inherent in conventional...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000330404.37092.3E
更新日期:2008-11-01 00:00:00
abstract:INTRODUCTION:The most frequent embryonic communication between the vertebrobasilar and carotid systems is a persistent trigeminal artery (PTA). It has been observed in 0.1 to 0.2% of cerebral angiograms. We found this variation in an anatomic specimen, and after microscopic dissection, we performed an analysis of the c...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199809000-00082
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVE:To determine the usefulness of endovascular embolization for treatment of dural arteriovenous fistulae of the superior petrosal sinus. METHODS:We performed a retrospective review of 18 patients treated during a 16-year period. Transarterial and/or transvenous embolizations were performed as a preoperative ad...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000068790.37318.24
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVE:A meta-analysis was performed to evaluate whether a beneficial clinical effect of cervical disk prostheses over conventional cervical diskectomy with fusion exists. METHODS:A literature search was completed ending February 4, 2009, that included the abstract books of recent major spine congresses. All studie...
journal_title:Neurosurgery
pub_type: 杂志文章,meta分析
doi:10.1227/01.NEU.0000369189.09182.5F
更新日期:2010-06-01 00:00:00
abstract::The authors present a case of acute aggravation of subdural effusion associated with pachymeningitis carcinomatosa. Microscopic examination of a surgical specimen revealed diffuse involvement of the dura mater by a metastatic adenocarcinoma in which the tumor cells invaded venules located in the areolar layer in parti...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199109000-00025
更新日期:1991-09-01 00:00:00
abstract:OBJECTIVE:The authors tested the hypothesis that among Grade II astrocytomas with a particularly long seizure history, a subgroup is hidden with a different prognosis and possibly histological characteristics. To do so, clinical and histological characteristics of two groups of World Health Organization Grade II astroc...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000129546.38675.1b
更新日期:2004-08-01 00:00:00
abstract::Meningiomas have a wide range of biological potential and clinical behavior. Histological findings are helpful in recognizing the malignant potential of a given tumor, but often fail to correlate with gross features, liability of recurrence, and extent of associated cerebral edema. To find alternate approaches to impr...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198812000-00006
更新日期:1988-12-01 00:00:00
abstract::Unexplained intraoperative or postoperative hemorrhage occurs in certain cases in the surgery of large arteriovenous malformations (AVMs), which are defined as those with maximal diameter of the nidus larger than 5 cm. Immediate postoperative angiograms were evaluated with reference to whether such hemorrhage could be...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-199309000-00008
更新日期:1993-09-01 00:00:00
abstract::Excessive mechanical stress on the intervertebral disc may be one of the causes of low back pain. Most studies testing this thesis, however, have been based on quantification of the mechanical response of functional units at failure. Typically, radiography is used to demonstrate trauma to the vertebral body at the fai...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198808000-00006
更新日期:1988-08-01 00:00:00
abstract::In this retrospective, consecutive series of 128 elderly patients (over 65 years of age) with histologically proven Grade 4 astrocytomas, 88 patients underwent stereotactic biopsy and 40 patients underwent stereotactic volumetric resection of the mass lesion defined by contrast enhancement on computed tomography. Ther...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::Negative findings on four-vessel angiography after a subarachnoid hemorrhage are seen in 5 to 30% of patients. A previously silent lesion in the spinal canal may be responsible for the ictus in a small percentage of this group. The etiological factors include tumors and arteriovenous malformations; however, investigat...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199010000-00022
更新日期:1990-10-01 00:00:00
abstract::The purpose of this study was to determine if the expression of receptor tyrosine kinases would distinguish astrocytosis from astrocytoma. Because the expression of this family of receptor proteins is greater in higher-grade tumors, a graded series of both reactive and neoplastic astrocytic lesions in humans was evalu...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-199307000-00017
更新日期:1993-07-01 00:00:00
abstract:OBJECTIVE:Vascular endothelial growth factor (VEGF)/vascular permeability factor (VPF) is a potent angiogenic growth factor implicated in the tumor angiogenesis/metastasis of a number of human cancers. Activation of receptors for VEGF/VPF is specifically mitogenic to endothelial cells and increases their permeability. ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199705000-00027
更新日期:1997-05-01 00:00:00
abstract:BACKGROUND:In Asian populations, moyamoya disease has a well-defined phenotype including a bimodal age of presentation with children typically presenting with ischemic phenomena and adults presenting with hemorrhage. Studies have provided evidence that moyamoya disease in the United States may exhibit a different pheno...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0b013e318253ab8e
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:Older age has been associated with worse outcomes in low-grade gliomas (LGGs). Given their rarity in the older population, determining optimal treatment plans and patient outcomes remains difficult. OBJECTIVE:To retrospectively study LGG survival outcomes in an older population stratified by molecular genet...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyy149
更新日期:2019-02-01 00:00:00
abstract::We report a case of a cerebral arteriovenous malformation presenting as a pseudotumor cerebri syndrome. The lack of mass effect, hemorrhage, or hydrocephalus, in addition to angiographic evidence of high-flow and venous outflow restriction, implicate increased cerebral blood flow and venous hypertension as the mechani...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1227/00006123-199503000-00020
更新日期:1995-03-01 00:00:00
abstract::Immortalized in surgical history for the introduction of "antiseptic wax," Sir Victor Horsley played a pivotal role in shaping the face of standard neurosurgical practice. His contributions include the first laminectomy for spinal neoplasm, the first carotid ligation for cerebral aneurysm, the curved skin flap, the tr...
journal_title:Neurosurgery
pub_type: 传,历史文章,杂志文章
doi:10.1097/00006123-200203000-00032
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVE:We compared long-term seizure outcome and health-related quality of life (HRQoL) of patients who underwent epilepsy surgery and matched medically treated nonsurgical controls with intractable epilepsy. METHODS:Medically treated controls were identified for patients operated on for epilepsy between January 1,...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000315999.58022.1c
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVE:Hypomania accounts for approximately 4% to 13% of psychotropic adverse events during subthalamic nucleus (STN) deep brain stimulation (DBS) for Parkinson's disease. Diffusion of current into the inferior and medial "limbic" STN is often reported to be the cause. We suggest a different explanation, in which th...
journal_title:Neurosurgery
pub_type: 临床试验,杂志文章
doi:10.1227/01.NEU.0000345631.54446.06
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:Patient-reported experience is often used as a measure for quality of care, but no reports on patient satisfaction after cranial neurosurgery exist. OBJECTIVE:To study the association of overall patient satisfaction and surgical outcome and to evaluate the applicability of overall patient satisfaction as a ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0000000000000931
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:Traditionally, thoracic fractures that require anterior stabilization are treated through an open thoracotomy approach. Thoracoscopic instrumentation avoids many of the complications associated with an open thoracotomy but is technically challenging. We report the first cases of dual-rod intern...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000119229.92157.66
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:We describe a patient with a tentorial dural arteriovenous fistula who presented with ipsilateral hemifacial spasm. CLINICAL PRESENTATION:A 50-year-old man sought treatment for left facial twitching that worsened over 6 months. Magnetic resonance imaging and catheter angiography demonstrated a...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000192386.89105.82
更新日期:2006-01-01 00:00:00
abstract::Intraoperative ultrasound can aid the biopsy of deep intracranial lesions. It is, perhaps, less clear whether ultrasound could be useful in functional neurosurgery, where the target is not abnormal in echogenicity. As an example, we chose to investigate in a dog model the periventricular gray target, which is frequent...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198408000-00002
更新日期:1984-08-01 00:00:00
abstract::Recent advances in electronics and microprocessors have enabled the development of a compact portable cerebral blood flow (CBF) machine capable of being transported to the patient's bedside. We have used such a device, the Novo Cerebrograph 2a, during the past 7 months on a regular basis in the day to day management o...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198410000-00008
更新日期:1984-10-01 00:00:00
abstract:OBJECTIVE:The microendoscopic discectomy (MED) technique was initially developed in 1997 to treat herniated lumbar disc disease. Since then, thousands of cases have been successfully performed at more than 500 institutions. This article discusses the technical aspects of this procedure and presents a consecutive case s...
journal_title:Neurosurgery
pub_type: 临床试验,杂志文章
doi:
更新日期:2002-11-01 00:00:00