Abstract:
BACKGROUND:Extent of resection (EOR) correlates with glioblastoma outcomes. Resectability and EOR depend on anatomical, clinical, and surgeon factors. Resectability likely influences outcome in and of itself, but an accurate measurement of resectability remains elusive. An understanding of resectability and the factors that influence it may provide a means to control a confounder in clinical trials and provide reference for decision making. OBJECTIVE:To provide proof of concept of the use of the collective wisdom of experienced brain tumor surgeons in assessing glioblastoma resectability. METHODS:We surveyed 13 academic tumor neurosurgeons nationwide to assess the resectability of newly diagnosed glioblastoma. Participants reviewed 20 cases, including digital imaging and communications in medicine-formatted pre- and postoperative magnetic resonance images and clinical vignettes. The selected cases involved a variety of anatomical locations and a range of EOR. Participants were asked about surgical goal, eg, gross total resection, subtotal resection (STR), or biopsy, and rationale for their decision. We calculated a "resectability index" for each lesion by pooling responses from all 13 surgeons. RESULTS:Neurosurgeons' individual surgical goals varied significantly ( P = .015), but the resectability index calculated from the surgeons' pooled responses was strongly correlated with the percentage of contrast-enhancing residual tumor ( R = 0.817, P < .001). The collective STR goal predicted intraoperative decision of intentional STR documented on operative notes ( P < .01) and nonresectable residual ( P < .01), but not resectable residual. CONCLUSION:In this pilot study, we demonstrate the feasibility of measuring the resectability of glioblastoma through crowdsourcing. This tool could be used to quantify resectability, a potential confounder in neuro-oncology clinical trials.
journal_name
Neurosurgeryjournal_title
Neurosurgeryauthors
Sonabend AM,Zacharia BE,Cloney MB,Sonabend A,Showers C,Ebiana V,Nazarian M,Swanson KR,Baldock A,Brem H,Bruce JN,Butler W,Cahill DP,Carter B,Orringer DA,Roberts DW,Sagher O,Sanai N,Schwartz TH,Silbergeld DL,Sisti Mdoi
10.1227/NEU.0000000000001374subject
Has Abstractpub_date
2017-04-01 00:00:00pages
590-601issue
4eissn
0148-396Xissn
1524-4040journal_volume
80pub_type
杂志文章相关文献
NEUROSURGERY文献大全abstract:BACKGROUND:Rotational vertebral artery syndrome (RVAS) is a rare entity about which previously published studies are mostly limited to individual case reports. OBJECTIVE:To report our decade-long experience with this syndrome in 9 patients with compression ranging from the occiput to C6. METHODS:We utilized a posteri...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0b013e3181ee36db
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:To describe the incidence and causes of pediatric head, spinal cord, and peripheral nerve injuries in an urban setting and to assess the implications of these data for injury prevention programs. METHODS:Pediatric deaths and hospital admissions secondary to neurological trauma included in the Northern Manhat...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199802000-00052
更新日期:1998-02-01 00:00:00
abstract:BACKGROUND:Neurosurgery, a demanding specialty, involves many microsurgical procedures that require complex skills, including open surgical treatment of intracranial aneurysms. Simulation or practice models may be useful for acquiring these skills before trainees perform surgery on human patients. OBJECTIVE:To describ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0000000000000553
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:Cigarette smoking has been demonstrated to increase the risk of subarachnoid hemorrhage (SAH). Whether cessation of smoking decreases this risk remains unclear. We performed a case-control study to examine the effect of smoking and other known risk factors for cerebrovascular disease on the risk of SAH. METH...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200109000-00014
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND:Accurate placement of a probe to the deep regions of the brain is an important part of neurosurgery. In the modern era, magnetic resonance image (MRI)-based target planning with frame-based stereotaxis is the most common technique. OBJECTIVE:To quantify the inaccuracy in MRI-guided frame-based stereotaxis a...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0b013e3182320bd6
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:Hyperbaric oxygenation is a rarely used method of treatment for steroid-refractory radiation-induced edema after stereotactic radiosurgery. We present its successful implementation for a radiosurgical complication after the treatment of a deep, large arteriovenous malformation. We also review the literature o...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000255343.41206.6F
更新日期:2007-03-01 00:00:00
abstract::Treatment of syringomyelia remains a difficult and controversial problem. However, the recent advent of magnetic resonance imaging (MRI) and intraoperative ultrasound allows a more precise approach to the diagnosis and management of this disorder. Experience with 27 cases of syringomyelia has shown that MRI is superio...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198704000-00016
更新日期:1987-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy of gamma knife (GK) radiosurgery, in terms of neurological improvement and tumor growth control (TGC), for a large series of patients with cavernous sinus meningiomas. METHODS:Between February 1993 and January 2002, 156 patients with cavernous sinus meningiomas (35 male and 121 femal...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200211000-00009
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:Risk factors for poor quality of life (QOL) after subarachnoid hemorrhage (SAH) remain poorly described. OBJECTIVE:To identify the frequency and predictors of poor QOL 1 year after SAH. METHODS:We studied 1-year QOL in a prospectively collected cohort of 1181 consecutively admitted SAH survivors between Ju...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0000000000001042
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:FLOW 800 delivers a color-coded map for snapshot visualization of the temporal distribution dynamics after indocyanine green angiography with post hoc calculation of FLOW 800-specific hemodynamic parameters. However, the value of these parameters regarding quantitative flow assessment remains unclear. OBJEC...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0000000000000277
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:Abducens nerve palsy is a rare and reversible complication associated with percutaneous radiofrequency trigeminal rhizolysis. CLINICAL PRESENTATION:An 86-year-old man developed an abducens nerve palsy immediately after undergoing percutaneous radiofrequency trigeminal rhizolysis for severe tri...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199809000-00134
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVE:Jugular foramen tumors are rare cranial base lesions that present diagnostic and management difficulties. With the availability of new diagnostic procedures these tumors have been more precisely studied and questions of whether, when, and how these lesions should be treated often arise. Data from 106 consecut...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000163483.44754.47
更新日期:2005-07-01 00:00:00
abstract::A case of cerebellopontine angle petrous bone osteoma manifesting as homolateral trigeminal neuralgia and causing a mild brain stem compression is presented. The literature concerning osteomas and particularly those affecting the temporal bone is reviewed. This is the second report of an osteoma located on the inner s...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1227/00006123-199412000-00018
更新日期:1994-12-01 00:00:00
abstract::Neurosurgery as a specialty medical field is new in Jordan. This article documents the history, current status, and projected future of neurosurgery in Jordan. Resident training is also highlighted, and challenges for the future of the profession are presented. ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199807000-00086
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND:Although there are several large-species animal models for saccular aneurysms, there is a need for a simple, reproducible saccular aneurysm model in mice. OBJECTIVE:To develop a murine saccular aneurysm model, which replicates key characteristics that occur in the formation of human cerebral aneurysms. MET...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000365616.46414.2B
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Current surgical management guidelines for pediatric spondylolisthesis (PS) are reliant on data from single-center cohorts. OBJECTIVE:To analyze national trends and predictors of short-term outcomes in spinal fusion surgery for PS by performing a retrospective cross-sectional analysis of the Kids' Inpatient...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyx295
更新日期:2018-05-01 00:00:00
abstract::ALTHOUGH FUNCTIONAL SURGERY for movement disorders did not begin in Korea until after the introduction of the stereotactic apparatus in 1958, some surgeons had already begun operating on epileptic patients, psychiatric patients, and patients with pain disorders even before the Korean War broke out in 1950. The Korean ...
journal_title:Neurosurgery
pub_type: 历史文章,杂志文章
doi:10.1227/01.neu.0000150061.77165.44
更新日期:2005-02-01 00:00:00
abstract::Three cases of intracranial meningioma unmasked by elective general anesthesia are reported. In each case, the meningioma was either asymptomatic or so subtly symptomatic that no suspicion of intracranial tumor had been entertained preoperatively. Each patient presented with failure to wake up after routine general an...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198403000-00012
更新日期:1984-03-01 00:00:00
abstract:OBJECTIVE:Basilar cranial fractures have been associated with injury to the carotid artery. We sought to determine whether fracture through the carotid canal was a significant risk factor for carotid injury. METHODS:A retrospective chart review was performed, and 230 patients with basilar cranial fractures were identi...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199706000-00012
更新日期:1997-06-01 00:00:00
abstract::Haemophilus influenzae meningitis in the presence of a cerebrospinal fluid shunt has been reported uncommonly. Staphylococcus aureus and Staphylococcus epidermidis, the most common etiological agents, are usually acquired by contiguous spread from an intraoperative or perioperative source. These infections usually occ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198601000-00013
更新日期:1986-01-01 00:00:00
abstract::This report describes a computed tomography-based computer-assisted stereotactic technique for performing 3rd ventriculostomy. The procedure has been performed on seven patients with acquired obstructive hydrocephalus of various etiologies. None of these patients have yet required shunting. ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198606000-00021
更新日期:1986-06-01 00:00:00
abstract::We report a case of a cerebral arteriovenous malformation presenting as a pseudotumor cerebri syndrome. The lack of mass effect, hemorrhage, or hydrocephalus, in addition to angiographic evidence of high-flow and venous outflow restriction, implicate increased cerebral blood flow and venous hypertension as the mechani...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1227/00006123-199503000-00020
更新日期:1995-03-01 00:00:00
abstract:OBJECTIVE:Deep brain stimulation (DBS) has become routine for the treatment of Parkinson's disease and essential tremor. Because both of these disorders are common in patients older than the age of 60, neurosurgeons are likely to encounter increasing numbers of patients who require DBS surgery but who already have anot...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000369646.01287.42
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:The optimal magnetic resonance angiography (MRA) sequence for assessing the aneurysm occlusion state or in-stent flow after endovascular coiling is not well established. OBJECTIVE:To evaluate the diagnostic performance of pointwise encoding time reduction with radial acquisition (PETRA)-MRA in patients who ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyaa467
更新日期:2021-01-13 00:00:00
abstract:BACKGROUND:Minimum clinical important difference (MCID) has been adopted as the smallest improvement in patient-reported outcome needed to achieve a level of improvement thought to be meaningful to patients. OBJECTIVE:To use a common MCID calculation method with a cost-utility threshold anchor to introduce the concept...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000462079.96571.dc
更新日期:2015-03-01 00:00:00
abstract::Infarction in the vertebrobasilar system is uncommon in children. Cerebellar infarction presenting as a posterior fossa mass lesion is distinctly rare. We recently treated a 13-year-old boy with such a lesion as a complication of basilar artery migraine. A review of the literature on vertebrobasilar infarction in chil...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198205000-00008
更新日期:1982-05-01 00:00:00
abstract:OBJECTIVE:The correct positioning of the electrode is of prime importance for effectiveness and selectivity of percutaneous trigeminal radiofrequency thermorhizotomy (RF-TR) for the treatment of trigeminal neuralgia (TN). The aim of our study was to establish some anatomoradiological landmarks for the purpose of accura...
journal_title:Neurosurgery
pub_type: 杂志文章,随机对照试验
doi:10.1227/01.neu.0000335027.00650.83
更新日期:2008-07-01 00:00:00
abstract::In a retrospective study of 48 patients who underwent elective surgery for cerebral arteriovenous malformations, a statistical analysis of demographic, clinical, and neuroradiological data was undertaken in order to discover the best predictors of operative morbidity. In addition, the predictive value of different cli...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198902000-00007
更新日期:1989-02-01 00:00:00
abstract:OBJECTIVE:To evaluate, regardless of the clinical results, the contribution of combining functional magnetic resonance imaging (fMRI) with intraoperative cortical brain mapping (iCM) as functional targeting methods for epidural chronic motor cortex stimulation (MCS) in refractory neuropathic pain. METHODS:Eighteen neu...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000333762.38500.ac
更新日期:2008-06-01 00:00:00
abstract::Coronary thrombolysis with streptokinase or tissue plasminogen activator is useful for the treatment of acute myocardial infarction in selected patients. This treatment is associated with local hemorrhagic complications and age-related cerebral hemorrhage. Coronary thrombolysis is contraindicated in patients with tran...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-199209000-00025
更新日期:1992-09-01 00:00:00