COX-2 dependent PGE(2) downregulates alpha(v) integrin expression via the EP(3) receptor in cultured mesangial cells.

abstract：AIMS:To study the overexpression of p53 protein in Barrett's oesophagus with adenocarcinoma, and to correlate this expression with the pathological features of Barrett's syndrome. METHODS:Immunohistochemical staining was performed on frozen sections with a monoclonal antibody directed against wild type and mutated p53...

journal_title：Journal of clinical pathology

authors： Fléjou JF,Potet F,Muzeau F,Le Pelletier F,Fékété F,Hénin D

更新日期：1993-04-01 00:00:00

abstract：AIM:To examine tumour samples immunohistochemically for MUC1 (episialin), epidermal growth factor receptor (EGFR), and c-erbB-2, since the disruption of the cell-cell adhesion system by MUC1 and the c-erbB oncoprotein family is known to be important in the development of metastasis in human cancers. METHODS:93 tumour ...

journal_title：Journal of clinical pathology

authors： Guddo F,Giatromanolaki A,Koukourakis MI,Reina C,Vignola AM,Chlouverakis G,Hilkens J,Gatter KC,Harris AL,Bonsignore G

更新日期：1998-09-01 00:00:00

abstract：AIMS:Heightened B-cell receptor (BCR) activity in diffuse large B-cell lymphoma (DLBCL) is well established, and a subset of patients with relapsed DLBCL can benefit from BCR-targeted therapies. Universal outreach of such emerging therapies mandates forming a global landscape of BCR molecular signalling in DLBCL, inclu...

journal_title：Journal of clinical pathology

authors： Masir N,Akhter A,Roshan TM,Florence CS,Abdul-Rahman F,Tumian NR,Kean-Chang P,Elyamany G,Shabani-Rad MT,Mansoor A

更新日期：2019-09-01 00:00:00

abstract：AIMS:To examine neuroendocrine differentiation, as shown by chromogranin A (CGA) expression, in cervical carcinomas. METHODS:Sixty seven cervical carcinomas were studied and were classified as adenocarcinomas, adenosquamous carcinomas or squamous cell carcinomas based on the assessment of haematoxylin and eosin staini...

journal_title：Journal of clinical pathology

authors： Savargaonkar PR,Hale RJ,Mutton A,Manning V,Buckley CH

更新日期：1996-02-01 00:00:00

abstract：:The activities of phosphohexose isomerase and 6-phosphogluconate dehydrogenase have been studied in the vaginal fluid of women from the gynaecological departments. Women from these departments gave a very high false positive rate, though no cases of carcinoma in situ were not detected by estimating phosphohexose isome...

journal_title：Journal of clinical pathology

authors： Muir GG

更新日期：1966-07-01 00:00:00

abstract：:This best practice review examines four series of common primary care questions in laboratory medicine: (i) "minor" blood platelet count and haemoglobin abnormalities; (ii) diagnosis and monitoring of anaemia caused by iron deficiency; (iii) secondary hyperlipidaemia and hypertriglyceridaemia; and (iv) glycated haemog...

journal_title：Journal of clinical pathology

authors： Smellie WS,Forth J,Bareford D,Twomey P,Galloway MJ,Logan EC,Smart SR,Reynolds TM,Waine C

更新日期：2006-08-01 00:00:00

abstract：:Sodium-alpha-naphthylamine-4-sulphonate (Naphthionin) appears to shorten the bleeding time in normal subjects and to be of value in the management of the bleeding defect in patients with thrombocytopenia when given by intravenous or intramuscular injection. A good response was achieved in three patients suffering from...

journal_title：Journal of clinical pathology

authors： POLLER L,MORE JR

更新日期：1964-11-01 00:00:00

abstract：:Expression profiling has been extensively applied to the study of breast cancer and undoubtedly is changing the way breast cancer is perceived. Over the past few years, several groups have described prognostic "signatures" (gene lists) that are purported to be more accurate prognostic factors than well established cli...

journal_title：Journal of clinical pathology

authors： Reis-Filho JS,Westbury C,Pierga JY

更新日期：2006-03-01 00:00:00

abstract：AIMS:The macroH2A histone variants are epigenetic marks for inactivated chromatin. In this study, we examined the expression of macroH2A2 in anal neoplasm from anal intraepithelial neoplasia (AIN) to anal squamous cell carcinoma (SCC). METHODS:AIN and anal SCC samples were analysed for macroH2A2 expression, HIV and hu...

journal_title：Journal of clinical pathology

authors： Hu WH,Miyai K,Sporn JC,Luo L,Wang JY,Cosman B,Ramamoorthy S

更新日期：2016-07-01 00:00:00

abstract：:The sensitivity of an indirect immunofluorescence antibody test (IFAT) and a rapid microagglutination test (RMAT) for the diagnosis of Legionnaires' disease caused by Legionella pneumophila serogroup 1 was evaluated using serum specimens from 119 patients with bacteriologically confirmed infections. The sensitivity of...

journal_title：Journal of clinical pathology

authors： Harrison TG,Dournon E,Taylor AG

更新日期：1987-01-01 00:00:00

abstract：:One hundred and seventyone antenatal patients were examined for the presence of ;large colony' mycoplasmas in the vagina, and for complement-fixing antibody to Mycoplasma hominis. In 25 patients the findings before and after delivery were compared. In patients from whom M. hominis was grown, antibody was twice as comm...

journal_title：Journal of clinical pathology

authors： Jones DM

更新日期：1967-07-01 00:00:00

abstract：:In a study of a group of 325 blood donors between the ages of 18 and 65 years, the total leucocyte and polymorph counts of the females aged 50 to 65 years were found to be significantly lower than those of the corresponding group of male donors. In the whole series of female donors, there were significantly lower tota...

journal_title：Journal of clinical pathology

authors： Allan RN,Alexander MK

更新日期：1968-11-01 00:00:00

abstract：BACKGROUND:Over 90% of Ewing's sarcoma/primitive neuroectodermal tumour (ES/PNET) cases have the t(11;22) chromosomal rearrangement, which is also found in other small round cell tumours, including desmoplastic small round cell tumour (DSRCT) and clear cell sarcoma (CCS). Although this rearrangement can be analysed by ...

journal_title：Journal of clinical pathology

authors： Yamaguchi U,Hasegawa T,Morimoto Y,Tateishi U,Endo M,Nakatani F,Kawai A,Chuman H,Beppu Y,Endo M,Kurotaki H,Furuta K

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:Venous invasion (VI) is an important prognosis predictor after colorectal carcinoma (CRC) resection, enabling more accurate staging and influencing postoperative management. AIMS:To assess/compare various tissue block types (perpendicular, tangential, across mesentery (AM), from major vessels or lymph nodes...

journal_title：Journal of clinical pathology

authors： Sternberg A,Mizrahi A,Amar M,Groisman G

更新日期：2006-02-01 00:00:00

abstract：:In a post-mortem analysis of 1,500 patients, aged 70 years or more, heart disease and malignancy were the two major causes of death. Coronary disease was exceedingly prevalent, almost one in five being subject to this form of heart disease, and 13% dying from its effects. The levelling of the sex ratio in coronary dis...

journal_title：Journal of clinical pathology

authors： MCKEOWN F

更新日期：1963-11-01 00:00:00

abstract：:The ultrastructure of the osteocytes, osteoblasts, osteoclasts, haemopoietic and other connective tissue cells was examined in 27 biopsies from 22 patients with Paget's disease of bone. Electron microscopy showed characteristic nuclear and cytoplasmic inclusions in the osteoclasts of all of the 25 biopsies exhibiting ...

journal_title：Journal of clinical pathology

authors： Harvey L,Gray T,Beneton MN,Douglas DL,Kanis JA,Russell RG

更新日期：1982-07-01 00:00:00

abstract：:Langerhans' cells were studied in the epidermis of two patients with active Behçet's disease and compared with those in two normal controls. Ultrastructural morphology and the percentage of Langerhans' cells found were similar in patients' (1.88%) and the control epidermis (1.79%). The density of Langerhans' cells in ...

journal_title：Journal of clinical pathology

authors： Kohn S,Haim S,Gilhar A,Friedman-Birnbaum R,Nir I

更新日期：1984-06-01 00:00:00

abstract：:This review focuses on the pathological features of dysplasia in Barrett's oesophagus. Two categorisation schemes are used for grading dysplasia in the gastrointestinal tract, including Barrett's oesophagus. The inflammatory bowel disease dysplasia morphology study group system is the one most commonly used in the USA...

journal_title：Journal of clinical pathology

authors： Odze RD

更新日期：2006-10-01 00:00:00

abstract：:Acute myocardial disease, which may be associated with abnormal platelet activity, has been reported after routine immunisation. Thirty-two army apprentices undergoing immunisation were studied for changes in the heparin neutralising activity (HNA) of platelet poor plasma. HNA increased after immunisation. This increa...

journal_title：Journal of clinical pathology

authors： Baker IA,Howells CH,O'Brien JR

更新日期：1979-11-01 00:00:00

abstract：AIMS:To assess the clinical efficacy of diagnostic procedures for breast cancer at a teaching hospital using internal auditing tools and quality control measures. METHODS:A retrospective assessment of 500 patients who underwent core needle biopsy (wide-bore needle biopsy; WBN) of palpable or non-palpable breast nodes ...

journal_title：Journal of clinical pathology

authors： Verenhitach BD,Elias S,Patrocínio AC,Nazário AC,Waizberg A

更新日期：2011-10-01 00:00:00

abstract：AIMS/BACKGROUND:A major medical role for postmortem examinations is the detection of clinically unexpected disease processes contributing to death. The aim of the present study was to determine whether simple clinical parameters can predict the presence of important unanticipated findings at necropsy. METHODS:Prospect...

journal_title：Journal of clinical pathology

authors： Robinson IA,Marley NJ

更新日期：1996-11-01 00:00:00

abstract：:The microwave tissue coagulator (MTC) is used in hepatectomy because it provides excellent haemostasis during the procedure. A 59 year old man underwent partial hepatic lobectomy with MTC, for metastasis from colon cancer. A tumorous necrotic nodule was discovered in the liver. The nodule measured 2.5 cm at its larges...

journal_title：Journal of clinical pathology

authors： Mikami Y,Shimizu M,Manabe T

更新日期：1997-08-01 00:00:00

abstract：:Two isolates of Proteus mirabilis and four of Esch. coli which would not grow on commonly used commercial sensitivity test media are reported. These organisms appear to be resistant to co-trimoxazole, are exacting towards thymidine, and five of six were isolated from patients who had been treated with co-trimoxazole. ...

journal_title：Journal of clinical pathology

authors： Barker J,Healing D,Hutchison JG

更新日期：1972-12-01 00:00:00

abstract：:The haematological features of 118 cases of primary myelodysplastic syndromes (PMDS) were reviewed to see how these could be related and classified according to the recent FAB proposals. A majority of the cases were elderly who presented with a macrocytic or normocytic anaemia and reticulocytopenia. Cases of acquired ...

journal_title：Journal of clinical pathology

authors： Juneja SK,Imbert M,Jouault H,Scoazec JY,Sigaux F,Sultan C

更新日期：1983-10-01 00:00:00

abstract：BACKGROUND:Receptor activator of nuclear factor kappabeta ligand (RANKL) has an important role in bone remodelling, and tumour necrosis factor related, apoptosis inducing ligand (TRAIL) can induce apoptosis in cancer cells. Their functions are linked by their interactions with osteoprotegerin (OPG). OBJECTIVE:To inves...

journal_title：Journal of clinical pathology

authors： Cross SS,Harrison RF,Balasubramanian SP,Lippitt JM,Evans CA,Reed MW,Holen I

更新日期：2006-07-01 00:00:00

abstract：:A histochemical method is described of differentiating between normal and neoplastic cells in plasma using the activity of various enzymes characteristic of plasma cells. It was found that in both types of cell increased or diminished activity of cytoenzymes is a useful means of distinguishing between normal and abnor...

journal_title：Journal of clinical pathology

authors： SZMIGIELSKI S,LITWIN J,ZUPANSKA B

更新日期：1965-05-01 00:00:00

abstract：:SF3B1 is the largest subunit of the Spliceosome Factor 3b (SF3B) complex and part of the U2 small nuclear ribosomal protein. It functions as an important part of spliceosomal assembly, converting precursor messenger RNA (mRNA) to mRNA ready for ribosomal translation. Mutations of SF3B1 are commonly seen in myelodyspla...

journal_title：Journal of clinical pathology

authors： Foy A,McMullin MF

更新日期：2019-11-01 00:00:00

abstract：:VARIOUS LABORATORIES HAVE REPORTED DIFFERING SUCCESS RATES IN THEIR ABILITY TO DETECT INTRATHECAL SYNTHESIS OF ANTIBODY WHEN COMPARING THE INDEX OF [FORMULA: see text] with electrophoretic analysis. We selected 44 patients in the borderline area of minimal and/or equivocal abnormality by IgG index. Electrophoretic ana...

journal_title：Journal of clinical pathology

authors： Thompson EJ,Riches PG,Kohn J

更新日期：1983-03-01 00:00:00

abstract：:The mucin and gland content of 26 rectal biopsy specimens--five normal specimens, 10 from patients with ulcerative colitis, and 11 from patients with Crohn's disease--were measured using a Quantimet image analyser. There was significantly less mucin in the groups with ulcerative colitis compared with either those with...

journal_title：Journal of clinical pathology

authors： McCormick DA,Horton LW,Mee AS

更新日期：1990-02-01 00:00:00

abstract：OBJECTIVE:To describe practical experiences in the sharing of very large digital data bases of histopathological imagery via the Internet, by investigators working in Europe, North America, and South America. MATERIALS:Experiences derived from medium power (sampling density 2.4 pixels/microm) and high power (6 pixels/...

journal_title：Journal of clinical pathology

authors： Montironi R,Thompson D,Scarpelli M,Bartels HG,Hamilton PW,da Silva VD,Sakr WA,Weyn B,van Daele A,Bartels PH

更新日期：2002-06-01 00:00:00