Abstract:
:Angiotensin II (AII), Asp1-Arg2-Val3-Tyr4-Ile5-His6-Pro7-Phe8, the primary active hormone of the Renin-Angiotensin-System (RAS), is a major vasoconstrictor implicated in the cause of hypertension. To unravel the question of the biologically active conformation(s) of this flexible peptide hormone and to better understand the stereoelectronic requirements that lead to the molecular basis of hypertension, we will analyze research efforts in the identification of pharmacophoric groups of AII and three general approaches for structural characterisation: the free peptide-ligand approach, the receptor based approach, and approaches that target the peptide-receptor complex. The free peptide-ligand based approach can be further categorized to: (a) conformational analysis of AII and linear peptide analogues in aqueous solution; (b) the use of solvents of medium dielectric constants; (c) conformationally restricted analogues, with emphasis to cyclic analogues; (d) the use of receptor-simulating environments, and (e) non-peptide mimetics. The receptor and peptide-receptor based approaches can be categorised to: (a) The use of monoclonal antibodies and (b) the generic description of AII receptor sites through homology modelling and mutagenesis studies. These investigations, with particular emphasis to recent developments, have greatly assisted in the identification of pharmacophoric groups for receptor activation and the development of several models of AII-receptor complexes.
journal_name
Curr Top Med Chemjournal_title
Current topics in medicinal chemistryauthors
Tzakos AG,Gerothanassis IP,Troganis ANdoi
10.2174/1568026043451375keywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
431-44issue
4eissn
1568-0266issn
1873-4294journal_volume
4pub_type
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