Abstract:
:Alpha-particles are of considerable growing interest for Targeted Alpha Therapy (TAT). TAT gains more attention as new targets, chemical labeling techniques and α-particle emitters are developed but translation of TAT into the clinic has been slow, in part because of the limited availability and the short physical half-lives of some of the available α-particle emitters. This article is an up-to-date overview of the literature concerning α-emitters used for TAT of cancer. It briefly describes the nuclear characteristics, the production parameters (targets, extraction and purification), the complexation properties of these radionuclides to chelates and biological vectors and finally draws-upon the preclinical and clinical studies that have been performed over the past two decades. Radiobiology and dosimetry aspects are also presented in this paper.
journal_name
Curr Top Med Chemjournal_title
Current topics in medicinal chemistryauthors
Huclier-Markai S,Alliot C,Varmenot N,Cutler CS,Barbet Jdoi
10.2174/1568026611212230002subject
Has Abstractpub_date
2012-01-01 00:00:00pages
2642-54issue
23eissn
1568-0266issn
1873-4294pii
CTMC-EPUB-20130104-16journal_volume
12pub_type
杂志文章,评审abstract::Urinary protein biomarkers and metabolomic markers have been leveraged to detect acute Drug Induced Kidney Injury (DIKI) in rats; however, the utility of these indicators to enable early detection of DIKI in canine models has not been well documented. Therefore, we evaluated temporal changes in biomarkers and metaboli...
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