Abstract:
:Overactive bladder has been successfully treated with oral anticholinergic drugs such as oxybutynin chloride. Although oral oxybutynin has been effective in controlling urinary urge incontinence and in decreasing incontinence episodes, adverse events, particularly dry mouth, often cause patients to discontinue oral therapy and to endure incontinence. Transdermal oxybutynin (Oxytrol, Watson Pharmaceuticals) is applied twice-weekly to maintain the efficacy of oral oxybutynin while significantly minimising side effects (e.g., dry mouth) that complicate therapy. By avoiding hepatic and gastrointestinal metabolism of oxybutynin, less N-desethyloxybutynin (N-DEO), the compound thought to be responsible for anticholinergic side effects, such as dry mouth, is produced. The new transdermal oxybutynin formulation offers patients with urinary incontinence an effective, safe and well-tolerated option for managing the symptoms of overactive bladder.
journal_name
Expert Opin Pharmacotherjournal_title
Expert opinion on pharmacotherapyauthors
Davila GWdoi
10.1517/14656566.4.12.2315keywords:
subject
Has Abstractpub_date
2003-12-01 00:00:00pages
2315-24issue
12eissn
1465-6566issn
1744-7666journal_volume
4pub_type
杂志文章,评审abstract:BACKGROUND:Lopinavir is a protease inhibitor with high specificity for HIV-1 protease formulated with ritonavir. Numerous clinical trials have shown that lopinavir/ritonavir (LPV/r) is highly effective as a component of highly active antiretroviral therapy (HAART) regimens for HIV-1 infection. OBJECTIVE:In this articl...
journal_title:Expert opinion on pharmacotherapy
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journal_title:Expert opinion on pharmacotherapy
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journal_title:Expert opinion on pharmacotherapy
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journal_title:Expert opinion on pharmacotherapy
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journal_title:Expert opinion on pharmacotherapy
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journal_title:Expert opinion on pharmacotherapy
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journal_title:Expert opinion on pharmacotherapy
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journal_title:Expert opinion on pharmacotherapy
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journal_title:Expert opinion on pharmacotherapy
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journal_title:Expert opinion on pharmacotherapy
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journal_title:Expert opinion on pharmacotherapy
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journal_title:Expert opinion on pharmacotherapy
pub_type: 杂志文章,评审
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journal_title:Expert opinion on pharmacotherapy
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更新日期:2014-06-01 00:00:00
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journal_title:Expert opinion on pharmacotherapy
pub_type: 社论
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更新日期:2014-02-01 00:00:00
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journal_title:Expert opinion on pharmacotherapy
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journal_title:Expert opinion on pharmacotherapy
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Expert opinion on pharmacotherapy
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journal_title:Expert opinion on pharmacotherapy
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