Lopinavir/ritonavir: a protease inhibitor for HIV-1 treatment.

abstract：INTRODUCTION:Despite its frequency, recognition and therapy of vulvovaginal atrophy (VVA) remain suboptimal. Wet mount microscopy, or vaginal pH as a proxy, allows VVA diagnosis in menopause, but also in young contraception users, after breast cancer, or postpartum. Intravaginal low dose estrogen product is the main th...

journal_title：Expert opinion on pharmacotherapy

authors： Donders GGG,Ruban K,Bellen G,Grinceviciene S

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:Mycophenolic acid (MPA), the active form of mycophenolate mofetil (MMF) and enteric-coated mycophenolate sodium (EC-MPS), is used to treat systemic lupus erythematosus (SLE). MMF and EC-MPS pharmacokinetics were examined to devise guidance for therapeutic drug monitoring (TDM) for SLE patients with normal ren...

journal_title：Expert opinion on pharmacotherapy

authors： Djabarouti S,Duffau P,Lazaro E,Chapouly C,Greib C,Viallard JF,Pellegrin JL,Saux MC,Breilh D

更新日期：2010-04-01 00:00:00

abstract：INTRODUCTION:Flecainide is a class Ic antiarrhythmic agent available in Europe since 1982. The clinical development program of flecainide provided good data on its antiarrhythmic effect for the prevention of ventricular and supraventricular arrhythmias. The Cardiac Arrhythmia Suppression Trial (CAST), conducted to test...

journal_title：Expert opinion on pharmacotherapy

authors： Apostolakis S,Oeff M,Tebbe U,Fabritz L,Breithardt G,Kirchhof P

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Obesity has become a global epidemic with recent estimates of > 400 million obese adults. Despite this, there are few safe and effective pharmacological interventions for obesity. Sibutramine is a weight loss agent, for use as an adjuvant to a comprehensive program of calorie restriction, exercise and behavi...

journal_title：Expert opinion on pharmacotherapy

authors： Sharma B,Henderson DC

更新日期：2008-08-01 00:00:00

abstract：:Introduction: Influenza represents a major public health threat worldwide. Implementation of good personal health and hygiene habits, together with vaccination, is the most effective tools to reduce influenza burden both in community and in healthcare setting. However, achieving adequate vaccination rates is challengi...

journal_title：Expert opinion on pharmacotherapy

authors： Bassetti M,Castaldo N,Carnelutti A

更新日期：2019-10-01 00:00:00

abstract：INTRODUCTION:Multiple myeloma is a disease predominately affecting older adults. Pivotal to treating older adults is understanding their physiologic differences compared to younger subjects and how the complexity of therapies has an impact upon this patient population. AREAS COVERED:Herein, the authors address the eff...

journal_title：Expert opinion on pharmacotherapy

authors： Dempsey JL,Johns A,Rosko AE,Lazarus HM

更新日期：2019-05-01 00:00:00

abstract：:Screening for sexually transmitted diseases is included in routine health care for several infectious agents in many western European countries. Current considerations on extensions of these programs include widespread screening strategies for Chlamydia trachomatis. In women, C. trachomatis infection may lead to seque...

journal_title：Expert opinion on pharmacotherapy

authors： Postma MJ,Welte R,Morré SA

更新日期：2002-10-01 00:00:00

abstract：INTRODUCTION:Bradykinin-mediated angioedema is characterized by subcutaneous and/or submucosal edema formation without wheals and pruritus. It is linked to bradykinin-enhanced vascular permeability and, therefore, it does not respond to conventional measures, but requires specific therapy. AREAS COVERED:This summary b...

journal_title：Expert opinion on pharmacotherapy

authors： Farkas H

更新日期：2013-04-01 00:00:00

abstract：INTRODUCTION:Hairy cell leukemia (HCL) is a B-cell lymphoid malignancy that accounts for approximately 2% of all leukemias. Treatment with purine nucleoside analogs (PNA) results in a high response rate and remains the standard of care. Long term follow-up shows that most patients relapse and require retreatment. Newer...

journal_title：Expert opinion on pharmacotherapy

authors： Ramos Perez J,Ravandi-Kashani F

更新日期：2020-08-01 00:00:00

abstract：:Seborrhoeic dermatitis (SD) is a chronic, inflammatory skin disorder, affecting areas of the head and body where sebaceous glands are most prominent and active. The disorder commonly affects hair-bearing areas of the head, including the scalp. Involvement on the face is usually limited to the hairline, eyebrows, nasol...

journal_title：Expert opinion on pharmacotherapy

authors： Faergemann J,Borgers M,Degreef H

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Fampridine-SR is under submission as the first drug to be FDA approved with an indication specifically for multiple sclerosis symptoms. Compounded forms of the active agent of Fampridine-SR (4-aminopyridine) have been used in clinical practice for many years. Clinical trials have now been completed that demo...

journal_title：Expert opinion on pharmacotherapy

authors： Kachuck NJ

更新日期：2009-08-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Current therapy for Parkinson's disease (PD) is primarily directed at reversing the motor symptoms that are the consequence of dopamine deficiency and includes levodopa, dopamine agonists and monoamine oxidase (MAO) B inhibitors. New drugs offering both dopaminergic and non-dopaminergic actions ...

journal_title：Expert opinion on pharmacotherapy

authors： Schapira AH

更新日期：2010-09-01 00:00:00

abstract：:Lapatinib is a dual (ErbB-1 and ErB-2) receptor tyrosine kinase inhibitor (TKI) that was recently approved by the FDA for the treatment of advanced breast cancer. It shows synergy with trastuzumab, and has demonstrated clinical activity in trastuzumab-resistant tumour. This paper reviews the drug development of lapati...

journal_title：Expert opinion on pharmacotherapy

authors： Mukherjee A,Dhadda AS,Shehata M,Chan S

更新日期：2007-09-01 00:00:00

abstract：INTRODUCTION:Disturbances in lipid metabolism represent an integral component of dysglycemic states and may increase the risk of diabetic complications. Although from a pathophysiological viewpoint fibrates could represent the ideal drug for patients with diabetic dyslipidemia the evidence that support their use in the...

journal_title：Expert opinion on pharmacotherapy

authors： Tsimihodimos V,Mikhailidis DP,Elisaf M

更新日期：2013-12-01 00:00:00

abstract：:The introduction of anti-TNFalpha therapy into the field of rheumatology has led to dramatic improvements in patient care, perhaps the most remarkable being in the management of ankylosing spondylitis. As experience with these compounds grows, their place in therapeutic strategy is becoming clearer, and it has been po...

journal_title：Expert opinion on pharmacotherapy

authors： Zochling J,Braun J

更新日期：2006-05-01 00:00:00

abstract：INTRODUCTION:Breast cancer (BC) remains the most frequently diagnosed cancer and the most common cause of cancer death among women of all races worldwide. Over 80% of BC cases are hormone receptor (HR)-positive, comprised of luminal A and luminal B per molecular subtypes, imposing an urgent need to fully understand the...

journal_title：Expert opinion on pharmacotherapy

authors： Duso BA,Trapani D,Viale G,Criscitiello C,D'Amico P,Belli C,Mazzarella L,Locatelli M,Minchella I,Curigliano G

更新日期：2018-02-01 00:00:00

abstract：INTRODUCTION:Myoclonic seizures are brief, involuntary muscular jerks arising from the central nervous system that can occur in different epilepsy syndromes, including idiopathic generalized epilepsies or the most severe group of epileptic encephalopathies. Valproate is commonly the first choice alone or in combination...

journal_title：Expert opinion on pharmacotherapy

authors： Striano P,Belcastro V

更新日期：2017-02-01 00:00:00

abstract：:Cervical dystonia (CD) manifests clinically through involuntary spasms of neck muscles, producing abnormal head and neck movements and postures, which is often associated with pain. CD is the most common form of focal dystonia presenting to movement disorders clinics. Chemodenervation with botulinum toxin (BTX) has be...

journal_title：Expert opinion on pharmacotherapy

authors： Tintner R,Jankovic J

更新日期：2001-12-01 00:00:00

abstract：INTRODUCTION:Prostate cancer being the second leading cause of death in men in Western countries remains a major challenge in healthcare. Several novel agents targeting signaling pathways in prostate cancer have recently been approved by the US Food and Drug Administration (FDA) but there is still an unmet need for new...

journal_title：Expert opinion on pharmacotherapy

authors： Deshmukh RR,Schmitt SM,Hwang C,Dou QP

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:Antifungal resistance is an emerging problem that increases morbidity and mortality in immunosuppressed pediatric patients, who suffer from invasive fungal diseases. Optimal pharmacological management is critical for the successful treatment of invasive fungal infections by resistant strains. AREAS COVERE...

journal_title：Expert opinion on pharmacotherapy

authors： Stergiopoulou T,Walsh TJ

更新日期：2015-02-01 00:00:00

abstract：INTRODUCTION:Breast cancer is the most frequently diagnosed cancer and the highest cause of cancer mortality in females worldwide. The development of drugs improving overall survival in late-stage metastatic breast cancer remains a challenge. Vinflunine is the most recently developed drug in the vinca alkaloid class. I...

journal_title：Expert opinion on pharmacotherapy

authors： Gourmelon C,Bourien H,Augereau P,Patsouris A,Frenel JS,Campone M

更新日期：2016-09-01 00:00:00

abstract：:This editorial considers the use of the first selective oral renin inhibitor, aliskiren, in reducing angiotensin (Ang) II reactivation or aldosterone (ALDO) escape during renin-angiotensin-aldosterone system (RAAS) inhibition. RAAS blockade with angiotensin converting enzyme inhibitors (ACEIs) and/or angiotensin recep...

journal_title：Expert opinion on pharmacotherapy

authors： Athyros VG,Mikhailidis DP,Kakafika AI,Tziomalos K,Karagiannis A

更新日期：2007-04-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Most guidelines suggest that failure of oral antidiabetic drugs should be followed by the addition of a basal insulin with aggressive titration of the dose. In most countries, neutral protamine Hagedorn (NPH)-insulin, glargine and detemir are the only choices. Clinical trials show that the metab...

journal_title：Expert opinion on pharmacotherapy

authors： Jensen MG,Hansen M,Brock B,Rungby J

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:The skin and the brain interact through psychoneuroimmunoendocrine mechanisms and through behaviors that can strongly influence the initiation or flaring of skin disorders. OBJECTIVE:To obtain knowledge of these factors to assist in designing treatment plans for specific skin disorders. METHODS:Psychocutan...

journal_title：Expert opinion on pharmacotherapy

authors： Shenefelt PD

更新日期：2008-04-01 00:00:00

abstract：INTRODUCTION:Silodosin is a new uroselective alpha-blocker with high pharmacological selectivity for the (1A) adrenoceptor. It is an effective and well-tolerated treatment in men with lower urinary tract symptoms (LUTS), due to presumed bladder outlet obstruction secondary to benign prostatic hyperplasia (BPH). The eff...

journal_title：Expert opinion on pharmacotherapy

authors： Osman NI,Chapple CR,Cruz F,Desgrandchamps F,Llorente C,Montorsi F

更新日期：2012-10-01 00:00:00

abstract：INTRODUCTION:Obstructive sleep apnea syndrome is a common public health problem in the general population. The important health-related consequences of obstructive sleep apnea include cardiovascular disorders, such as myocardial infarction and hypertension, stroke, sudden death and difficult blood sugar control related...

journal_title：Expert opinion on pharmacotherapy

authors： Lin CM,Huang YS,Guilleminault C

更新日期：2012-04-01 00:00:00

abstract：:Parkinson's disease (PD) affects approximately 1% of individuals > 60 years. Of these PD patients approximately 40% suffer dementia in later life. Levodopa is commonly used in the treatment of PD. Experimental evidence suggests that the dopamine synthesised from levodopa may contribute to the further degeneration of d...

journal_title：Expert opinion on pharmacotherapy

authors： Doggrell SA

更新日期：2005-06-01 00:00:00

abstract：:The development of effective treatments for opioid dependence is of great importance given the devastating consequences of the disease. Pharmacotherapies for opioid addiction include opioid agonists, partial agonists, opioid antagonists, and alpha-2-adrenergic agonists, which are targeted toward either detoxification ...

journal_title：Expert opinion on pharmacotherapy

authors： Stotts AL,Dodrill CL,Kosten TR

更新日期：2009-08-01 00:00:00

abstract：:This is a review of the literature comparing the efficacy and safety of drug-eluting stents (DES) versus bare-metal stents (BMS) in patients with acute myocardial infarction (MI). The present article reviews whether DES are beneficial in the setting of primary percutaneous coronary intervention (PCI), and this has bee...

journal_title：Expert opinion on pharmacotherapy

authors： Yeter E,Kurt M,Silay Y,Anderson HV,Denktas AE

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:According to current guidelines, malignant hypertension is one of the emergencies in hypertension. The definition requires the presence of bilateral retinal hemorrhages or exudates, with or without papilledema, acute heart failure and acute deterioration in renal function in severe hypertension. Patients w...

journal_title：Expert opinion on pharmacotherapy

authors： Lewek J,Bielecka-Dąbrowa A,Maciejewski M,Banach M

更新日期：2020-07-01 00:00:00