Personalized treatment of EGFR mutant and ALK-positive patients in NSCLC.

abstract：:Gestational diabetes (GD) develops because pregnancy increases requirements for insulin secretion while increasing insulin resistance. Women with GD often have impaired pancreatic beta-cell compensation for insulin resistance. The nature of GD is currently contentious, with debate about its existence, diagnosis and ra...

journal_title：Expert opinion on pharmacotherapy

authors： Glueck CJ,Goldenberg N,Streicher P,Wang P

更新日期：2002-11-01 00:00:00

abstract：:Cronkhite-Canada syndrome (CCS) is a rare, non-inherited gastrointestinal polyposis syndrome associated with characteristic ectodermal abnormalities. A number of potentially life-threatening complications including malnutrition, gastrointestinal bleeding and infection may occur in affected patients and CCS is fatal in...

journal_title：Expert opinion on pharmacotherapy

authors： Ward EM,Wolfsen HC

更新日期：2003-03-01 00:00:00

abstract：:Human infections with Babesia species, in particular Babesia microti, are tick-borne illnesses that are being recognised with increased frequency. Coinfection with ehrlichiosis and Lyme disease is also being recognised as an important feature of these tick-borne illnesses. Despite the superficial resemblance of Babesi...

journal_title：Expert opinion on pharmacotherapy

authors： Weiss LM

更新日期：2002-08-01 00:00:00

abstract：INTRODUCTION:The alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors are the major mediators of glutamate-mediated excitatory neurotransmission, and are critical for synchronization and spread of epileptic activity. Areas covered: AMPA receptor antagonists have been also developed as antiepilepti...

journal_title：Expert opinion on pharmacotherapy

authors： Di Bonaventura C,Labate A,Maschio M,Meletti S,Russo E

更新日期：2017-11-01 00:00:00

abstract：INTRODUCTION:Irritable bowel syndrome (IBS) treatment is challenging physicians because of its multifactorial physiopathology. In particular, abdominal pain and diarrhea management lack one unique effective pharmacological remedy. Opioid receptors, present in the central nervous system (CNS) and the enteric nervous sys...

journal_title：Expert opinion on pharmacotherapy

authors： Scarpellini E,Laterza L,Ianiro G,Tack J,Abenavoli L,Gasbarrini A

更新日期：2016-07-01 00:00:00

abstract：:Introduction: Spondyloarthritis (SpA) refers to a group of disorders sharing common clinical, genetic and imaging characteristics. Axial (ax) SpA corresponds to a subgroup that mainly affects the axial skeleton, leading to inflammatory back pain and progressive radiographic changes of the sacroiliac joints and the spi...

journal_title：Expert opinion on pharmacotherapy

authors： Toussirot E

更新日期：2019-08-01 00:00:00

abstract：INTRODUCTION:Generalized anxiety disorder (GAD) is a chronic, relapsing, debilitating disorder, associated with markedly impaired social and occupational functioning. Pharmacological treatment is considered standard care and several drug classes are now FDA approved for the treatment of GAD. While there are clear data ...

journal_title：Expert opinion on pharmacotherapy

authors： Reinhold JA,Mandos LA,Rickels K,Lohoff FW

更新日期：2011-11-01 00:00:00

abstract：:Autonomic dysreflexia is a potentially life-threatening hypertensive medical emergency that occurs most often in spinal cord-injured individuals with spinal lesions at or above the mid-thoracic spinal cord level. It is a condition that remains poorly recognised outside of spinal cord injury centres, which may result i...

journal_title：Expert opinion on pharmacotherapy

authors： Khastgir J,Drake MJ,Abrams P

更新日期：2007-05-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Current therapy for Parkinson's disease (PD) is primarily directed at reversing the motor symptoms that are the consequence of dopamine deficiency and includes levodopa, dopamine agonists and monoamine oxidase (MAO) B inhibitors. New drugs offering both dopaminergic and non-dopaminergic actions ...

journal_title：Expert opinion on pharmacotherapy

authors： Schapira AH

更新日期：2010-09-01 00:00:00

abstract：:Overactive bladder (OAB) is a common problem. Affected individuals suffer decreased quality of life and productivity. The mainstay of pharmacological treatment of OAB is antimuscarinic agents. Tolterodine was the first antimuscarinic drug designed specifically for treating OAB. Compared with the immediate-release (IR)...

journal_title：Expert opinion on pharmacotherapy

authors： Chung DE,Te AE

更新日期：2009-09-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Treatment options for metastatic colorectal cancer (mCRC) patients have rapidly increased in the past years, but 50 - 70% of mCRC patients are still unlikely to undergo radical resection of metastases and are candidates for palliative therapy only. AREAS COVERED IN THIS REVIEW:Oxaliplatin and i...

journal_title：Expert opinion on pharmacotherapy

authors： Fornaro L,Masi G,Loupakis F,Vasile E,Falcone A

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Constituting approximately 30% of lymphoid malignancies, diffuse large B-cell lymphoma (DLBCL) is the most common aggressive lymphoma in adults worldwide. The clinical and biologic heterogeneity that exists in DLBCL suggests that this entity might actually be comprised of several distinct neoplasms that coul...

journal_title：Expert opinion on pharmacotherapy

authors： Escalón MP,Lossos IS

更新日期：2008-09-01 00:00:00

abstract：:Introduction: Triptorelin is a luteinizing hormone-releasing hormone analog (LH-RHa) inducing ovarian function suppression (OFS). It is approved by FDA and EMA in association with tamoxifen or aromatase inhibitor (AI) and with fulvestrant and palbociclib in premenopausal women with hormone receptor (HR)-positive breas...

journal_title：Expert opinion on pharmacotherapy

authors： Ferraro E,Trapani D,Marrucci E,Curigliano G

更新日期：2019-10-01 00:00:00

abstract：:Fluticasone propionate (FP) is a potent inhaled corticosteroid (ICS) for the treatment of asthma. It is currently marketed in both the United States (as Flovent) and Europe (as Flixotide). Fluticasone is available in both aerosolised metered dose inhaler (MDI) and dry powder devices, with dosages ranging from 44-500 m...

journal_title：Expert opinion on pharmacotherapy

authors： Staresinic AG,Sorkness CA

更新日期：2000-09-01 00:00:00

abstract：:Chronic kidney diseases frequently advance to end-stage renal failure, and the number of patients affected is steadily increasing worldwide. At the molecular level, progression of renal insufficiency correlates closely with ongoing pathological matrix protein expansion (i.e., renal fibrosis), in a manner independent o...

journal_title：Expert opinion on pharmacotherapy

authors： Gaedeke J,Neumayer HH,Peters H

更新日期：2006-03-01 00:00:00

abstract：INTRODUCTION:Status Epilepticus (SE) is the most common neurological emergency of childhood. It requires prompt administration of appropriately selected anti-seizure medications. Areas covered: Following a distinction between estabilished and emergent drugs, we present pharmacological treatment options and their clinic...

journal_title：Expert opinion on pharmacotherapy

authors： Verrotti A,Ambrosi M,Pavone P,Striano P

更新日期：2017-06-01 00:00:00

abstract：:The recently published Abaloparatide Comparator Trial in Vertebral Endpoints (ACTIVE) assessed the efficacy and safety of abaloparatide (80 µg daily subcutaneous) (ABL) vs placebo during 18 months, in postmenopausal osteoporosis. Teriparatide (20 µg daily subcutaneous) (TPD) was used as an open label active comparator...

journal_title：Expert opinion on pharmacotherapy

authors： Reginster JY,Al Daghri NM,Bruyere O

更新日期：2017-12-01 00:00:00

abstract：INTRODUCTION:Many clinical trials have been conducted with chemotherapies in patients with advanced hepatocellular carcinoma (HCC). However, few agents have shown efficacy. It is thought that the efficacy of some agents might have resulted from the heterogeneity of tumors, insufficient dosages due to liver cirrhosis, a...

journal_title：Expert opinion on pharmacotherapy

authors： Yamamoto S,Kondo S

更新日期：2018-06-01 00:00:00

abstract：INTRODUCTION:When estimating the cost-effectiveness or budget impact of chronic obstructive pulmonary disease (COPD) medication, it is common practice to use trial data for clinical inputs. However, such inputs do not always reflect the real-world situation. Previous reviews recognized the need for taking real-world da...

journal_title：Expert opinion on pharmacotherapy

authors： Fens T,Zhou G,Postma MJ,van Puijenbroek EP,van Boven JFM

更新日期：2021-01-13 00:00:00

abstract：:Pregnancies complicated by diabetes mellitus (DM) include pregestational DM and gestational DM, defined as carbohydrate intolerance of variable severity first detected during pregnancy. DM leads to poor pregnancy outcome. The aim of treatment is to control maternal hyperglycaemia and to imitate postprandial insulin re...

journal_title：Expert opinion on pharmacotherapy

authors： González C,Santoro S,Salzberg S,Di Girolamo G,Alvariñas J

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Miconazole nitrate is a time-honored antifungal of the imidazole class. OBJECTIVE:To revisit the various aspects of action of the drug in a dermatologic setting. METHOD:Review of the current peer-reviewed publications. RESULTS/CONCLUSION:Miconazole essentially inhibits 14alpha-demethylase, an enzyme requi...

journal_title：Expert opinion on pharmacotherapy

authors： Quatresooz P,Vroome V,Borgers M,Cauwenbergh G,Piérard GE

更新日期：2008-08-01 00:00:00

abstract：INTRODUCTION:Treating acute myeloid leukemia (AML) in older adults remains daunting. The unique biology often renders conventional chemotherapies less effective. Accurately predicting the toxicities of treatment is another unresolved challenge. Treatment planning thus requires a good knowledge of the current trial data...

journal_title：Expert opinion on pharmacotherapy

authors： Michaelis LC,Klepin HD,Walter RB

更新日期：2018-06-01 00:00:00

abstract：INTRODUCTION:Hypertension is highly prevalent in patients with end-stage kidney disease on hemodialysis and is often not well controlled. Blood pressure (BP) levels before and after hemodialysis have a U-shaped relationship with cardiovascular and all-cause mortality. Although antihypertensive drugs are recommended for...

journal_title：Expert opinion on pharmacotherapy

authors： Maruyama T,Takashima H,Abe M

更新日期：2020-07-01 00:00:00

abstract：INTRODUCTION:Lefamulin is a novel antibiotic that belongs to the pleuromutilin class with excellent activity against all microorganisms, including atypical pathogens, that cause community-acquired pneumonia (CAP). AREAS COVERED:This article reviews the spectrum of activity, the main pharmacokinetic and pharmacodynamic...

journal_title：Expert opinion on pharmacotherapy

authors： Falcó V,Burgos J,Almirante B

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:The intent of this pooled analysis was to determine the relationship between baseline depression symptom severity and treatment response for escitalopram compared to that for other pooled antidepressant medications (citalopram, duloxetine, fluoxetine, paroxetine, sertraline and venlafaxine). METHODS:Data wer...

journal_title：Expert opinion on pharmacotherapy

authors： Kilts CD,Wade AG,Andersen HF,Schlaepfer TE

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Moderate hypertriglyceridemia is fairly common, and elevated triglycerides are a risk factor for coronary heart disease. The omega-3 fatty acids EPA and DHA have been shown to lower triglycerides in many clinical studies. Prescription omega-3 fatty acid concentrates (P-OM3) are indicated for use in people wi...

journal_title：Expert opinion on pharmacotherapy

authors： Skulas-Ray AC,West SG,Davidson MH,Kris-Etherton PM

更新日期：2008-05-01 00:00:00

abstract：INTRODUCTION:The pharmacotherapeutic management of depression in patients with multiple sclerosis (MS) is a matter of debate that cannot be decided from the evidence available in the current literature. Therefore, its management essentially relies on the clinical experience of the prescribing clinician rather than on e...

journal_title：Expert opinion on pharmacotherapy

authors： Carta MG,Paribello P,Anastasia A,De Berardis D,Nardi AE,Fornaro M

更新日期：2018-10-01 00:00:00

abstract：INTRODUCTION:Angioedema, a sudden, self-limited swelling of localized areas of any part of the body that may or may not be associated with urticaria, is thought to be the result of a mast-cell mediated process versus a bradykinin etiology. Understanding the mechanism is key in determining the proper treatment. Areas Co...

journal_title：Expert opinion on pharmacotherapy

authors： James C,Bernstein JA

更新日期：2017-02-01 00:00:00

abstract：:This article reviews the evidence supporting different somatic treatment strategies in the acute and maintenance treatment phases of bipolar disorder. Bipolar affective disorder is a chronic disorder with a life time incidence of 0.3 - 1.5/100 [1]. Severe affective disorder is associated with a risk of completed suici...

journal_title：Expert opinion on pharmacotherapy

authors： Watson S,Young AH

更新日期：2001-04-01 00:00:00

abstract：INTRODUCTION:Pharmacological treatment plays a major role in the management of advanced, persistent or recurrent uterine leiomyosarcoma (LMS), whereas its usefulness in the adjuvant setting is still debated. A thorough literature search was undertaken using the Pubmed databases. Systematic reviews and controlled trials...

journal_title：Expert opinion on pharmacotherapy

authors： Gadducci A,Guerrieri ME

更新日期：2015-02-01 00:00:00