[No association of 141C-ins/del polymorphism in the D2 dopamine receptor gene in schizophrenia].

Abstract:

:Recently, a putative functional polymorphism (-141C Ins/Del) in the 5'-flanking region of the dopamine D2 receptor was found. An association of the Ins allele with schizophrenia has been described in a Japanese sample. In the present study this association was examined in a German schizophrenia patient population. In a family based approach 190 German family trios were analyzed for the -141C Ins/Del genotype. Using the transmission disequilibrium test (TDT) we found no evidence for an association of the Ins allele with schizophrenia (TDT = 0.152, P = 0.696). In parallel, we performed an independent case control study with 268 schizophrenic patients and 244 controls. Again, we did not detect an overrepresentation of the Ins allele in patients (P = 0.124). Thus, our data do not support the hypothesis that the -141C Ins variant plays a major role in predisposition to schizophrenia. To confirm our conclusion further preferentially family based studies are needed.

journal_name

Psychiatr Prax

journal_title

Psychiatrische Praxis

authors

Rohrmeier T,Putzhammer A,Sartor H,Knapp M,Albus M,Borrmann-Hassenbach M,Lichtermann D,Wildenauer D,Schwab S,Maier W,Klein HE,Eichhammer P

keywords:

subject

Has Abstract

pub_date

2003-05-01 00:00:00

pages

S212-5

eissn

0303-4259

issn

1439-0876

journal_volume

30 Suppl 2

pub_type

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