Abstract:
:Recently, a putative functional polymorphism (-141C Ins/Del) in the 5'-flanking region of the dopamine D2 receptor was found. An association of the Ins allele with schizophrenia has been described in a Japanese sample. In the present study this association was examined in a German schizophrenia patient population. In a family based approach 190 German family trios were analyzed for the -141C Ins/Del genotype. Using the transmission disequilibrium test (TDT) we found no evidence for an association of the Ins allele with schizophrenia (TDT = 0.152, P = 0.696). In parallel, we performed an independent case control study with 268 schizophrenic patients and 244 controls. Again, we did not detect an overrepresentation of the Ins allele in patients (P = 0.124). Thus, our data do not support the hypothesis that the -141C Ins variant plays a major role in predisposition to schizophrenia. To confirm our conclusion further preferentially family based studies are needed.
journal_name
Psychiatr Praxjournal_title
Psychiatrische Praxisauthors
Rohrmeier T,Putzhammer A,Sartor H,Knapp M,Albus M,Borrmann-Hassenbach M,Lichtermann D,Wildenauer D,Schwab S,Maier W,Klein HE,Eichhammer Pkeywords:
subject
Has Abstractpub_date
2003-05-01 00:00:00pages
S212-5eissn
0303-4259issn
1439-0876journal_volume
30 Suppl 2pub_type
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journal_title:Psychiatrische Praxis
pub_type: 杂志文章
doi:
更新日期:2003-05-01 00:00:00
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journal_title:Psychiatrische Praxis
pub_type: 杂志文章
doi:
更新日期:1999-03-01 00:00:00
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journal_title:Psychiatrische Praxis
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
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journal_title:Psychiatrische Praxis
pub_type: 杂志文章
doi:10.1055/s-2007-970974
更新日期:2007-09-01 00:00:00
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journal_title:Psychiatrische Praxis
pub_type: 杂志文章
doi:10.1055/a-0801-3847
更新日期:2019-04-01 00:00:00
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journal_title:Psychiatrische Praxis
pub_type: 杂志文章
doi:10.1055/s-2005-866920
更新日期:2007-01-01 00:00:00
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journal_title:Psychiatrische Praxis
pub_type: 杂志文章
doi:10.1055/s-0044-102189
更新日期:2018-07-01 00:00:00
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journal_title:Psychiatrische Praxis
pub_type: 杂志文章
doi:
更新日期:1986-09-01 00:00:00
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journal_title:Psychiatrische Praxis
pub_type: 杂志文章
doi:10.1055/a-0584-9803
更新日期:2018-11-01 00:00:00
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journal_title:Psychiatrische Praxis
pub_type: 杂志文章
doi:10.1055/s-2001-12672
更新日期:2001-04-01 00:00:00
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journal_title:Psychiatrische Praxis
pub_type: 杂志文章
doi:10.1055/s-2002-34034
更新日期:2002-09-01 00:00:00
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journal_title:Psychiatrische Praxis
pub_type: 杂志文章
doi:
更新日期:1994-09-01 00:00:00
abstract::Since the 1980's psychiatric care in Spain changed considerably (Reforma psiquiátrica española). In the course of this reform, many positive results were achieved. An extensive community network of mental health centres was build up which resulted in the majority of psychiatric patients being integrated in the Spanish...
journal_title:Psychiatrische Praxis
pub_type: 杂志文章
doi:
更新日期:2000-11-01 00:00:00
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journal_title:Psychiatrische Praxis
pub_type: 杂志文章
doi:10.1055/a-1159-5575
更新日期:2020-05-01 00:00:00
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journal_title:Psychiatrische Praxis
pub_type: 杂志文章
doi:10.1055/s-0029-1223403
更新日期:2010-04-01 00:00:00
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journal_title:Psychiatrische Praxis
pub_type: 杂志文章
doi:
更新日期:1988-05-01 00:00:00
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journal_title:Psychiatrische Praxis
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
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journal_title:Psychiatrische Praxis
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
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journal_title:Psychiatrische Praxis
pub_type: 杂志文章,评审
doi:10.1055/s-2007-986410
更新日期:2008-04-01 00:00:00
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journal_title:Psychiatrische Praxis
pub_type: 杂志文章
doi:10.1055/s-2002-22041
更新日期:2002-03-01 00:00:00
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journal_title:Psychiatrische Praxis
pub_type: 杂志文章,评审
doi:10.1055/s-0029-1223364
更新日期:2010-05-01 00:00:00
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journal_title:Psychiatrische Praxis
pub_type: 杂志文章
doi:10.1055/s-0034-1369867
更新日期:2014-10-01 00:00:00
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journal_title:Psychiatrische Praxis
pub_type: 杂志文章
doi:
更新日期:1985-05-01 00:00:00
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journal_title:Psychiatrische Praxis
pub_type: 杂志文章
doi:10.1055/a-0915-3990
更新日期:2019-09-01 00:00:00
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journal_title:Psychiatrische Praxis
pub_type: 杂志文章
doi:10.1055/s-0032-1327251
更新日期:2013-01-01 00:00:00
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journal_title:Psychiatrische Praxis
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
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journal_title:Psychiatrische Praxis
pub_type: 杂志文章
doi:10.1055/s-0042-122327
更新日期:2019-03-01 00:00:00
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journal_title:Psychiatrische Praxis
pub_type: 杂志文章
doi:10.1055/s-0034-1387365
更新日期:2015-11-01 00:00:00
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journal_title:Psychiatrische Praxis
pub_type: 杂志文章
doi:10.1055/s-2001-17791
更新日期:2001-10-01 00:00:00
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journal_title:Psychiatrische Praxis
pub_type: 杂志文章
doi:10.1055/s-2005-866923
更新日期:2006-01-01 00:00:00