Biophysical model of synaptic plasticity dynamics.

Abstract:

:We discuss a biophysical model of synaptic plasticity that provides a unified view of the outcomes of synaptic modification protocols, including: (1) prescribed time courses of postsynaptic intracellular Ca(2+) release, (2) postsynaptic voltage clamping with presentation of presynaptic spike trains at various frequencies, (3) direct postsynaptic response to presynaptic spike trains at various frequencies, and (4) LTP/LTD as a response to precisely timed presynaptic and postsynaptic spikes.

journal_name

Biol Cybern

journal_title

Biological cybernetics

authors

Abarbanel HD,Gibb L,Huerta R,Rabinovich MI

doi

10.1007/s00422-003-0422-x

keywords:

subject

Has Abstract

pub_date

2003-09-01 00:00:00

pages

214-26

issue

3

eissn

0340-1200

issn

1432-0770

journal_volume

89

pub_type

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