Abstract：
:Tractography uses diffusion tensor imaging data to trace white matter pathways in vivo within the brain. We have constructed group maps that represent three major white matter tracts-the anterior callosal fibers, optic radiations, and pyramidal tracts-in a group of 21 volunteers. For each individual tract the fast marching tractography (FMT) algorithm was used to generate a VSC (voxel scale connectivity) map in native space. Using SPM99 these maps were transformed into a standard reference frame and three group mapping techniques were investigated: the first averaged the individual VSC maps, the second produced maps that demonstrate intersubject tract variability and degree of overlap, and the third used an SPM analysis to construct a statistical image that represents the group effect. The group maps reconstructed for each tract under investigation conform well to known anatomy and are consistent with data derived from postmortem human brains. Greater intersubject variability is found around the terminal projections of the tracts adjacent to cerebral cortex, whereas the "core" of each tract is characterized by lower variability. No significant differences were found between the left and right side of the pyramidal tracts and optic radiations. The group mapping techniques utilize the VSC maps in different but complementary ways. In the future, group mapping could investigate in vivo white matter differences between normal subjects and patients affected by neurological and psychiatric diseases.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Ciccarelli O,Toosy AT,Parker GJ,Wheeler-Kingshott CA,Barker GJ,Miller DH,Thompson AJdoi
10.1016/s1053-8119(03)00190-3keywords:
subject
Has Abstractpub_date
2003-08-01 00:00:00pages
1545-55issue
4eissn
1053-8119issn
1095-9572pii
S1053811903001903journal_volume
19pub_type
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