The effect of preceding context on inhibition: an event-related fMRI study.


:In this study we combined event-related fMRI with a parametric manipulation of the go nogo paradigm to examine the effect of preceding context on inhibitory processes. Nogo trials were preceded by either 1, 3, or 5 go trials and then compared to one another. Two distinct patterns of activation were associated with behavioral inhibition: First, the ventral prefrontal cortex, cingulate gyrus, and superior parietal regions showed a context effect with an increase in MR signal to nogo trials with increasing number of preceding go trials. Second, anterior regions in the supplementary and premotor cortex showed an increase in MR signal on the nogo condition after 5 preceding go trials, but not after only 1 or 3. A model using the BOLD response in our data was used to verify that the effect of context was not an artifact of the randomization scheme used in the design.






Durston S,Thomas KM,Worden MS,Yang Y,Casey BJ





Has Abstract


2002-06-01 00:00:00














  • Demyelination and degeneration in the injured human spinal cord detected with diffusion and magnetization transfer MRI.

    abstract::Characterizing demyelination/degeneration of spinal pathways in traumatic spinal cord injured (SCI) patients is crucial for assessing the prognosis of functional rehabilitation. Novel techniques based on diffusion-weighted (DW) magnetic resonance imaging (MRI) and magnetization transfer (MT) imaging provide sensitive ...


    pub_type: 杂志文章


    authors: Cohen-Adad J,El Mendili MM,Lehéricy S,Pradat PF,Blancho S,Rossignol S,Benali H

    更新日期:2011-04-01 00:00:00

  • Phasic deactivation of the medial temporal lobe enables working memory processing under stress.

    abstract::Demanding cognitive tasks are sometimes carried out under stressful conditions. Several studies indicate that whereas severe stress impairs performance, moderate stress can enhance cognitive performance. In this study, we investigated how moderate stress influences the neural systems supporting working memory. We embe...


    pub_type: 杂志文章


    authors: Cousijn H,Rijpkema M,Qin S,van Wingen GA,Fernández G

    更新日期:2012-01-16 00:00:00

  • A ventral striatal prediction error signal in human fear extinction learning.

    abstract::Animal studies have shown that the prediction error (PE) signal that drives fear extinction learning is encoded by phasic activity of midbrain dopamine (DA) neurons. Thus, the extinction PE resembles the appetitive PE that drives reward learning. In humans, fear extinction learning is less well understood. Using compu...


    pub_type: 杂志文章


    authors: Thiele M,Yuen KSL,Gerlicher AVM,Kalisch R

    更新日期:2021-01-15 00:00:00

  • Is it time to re-prioritize neuroimaging databases and digital repositories?

    abstract::The development of in vivo brain imaging has lead to the collection of large quantities of digital information. In any individual research article, several tens of gigabytes-worth of data may be represented-collected across normal and patient samples. With the ease of collecting such data, there is increased desire fo...


    pub_type: 杂志文章


    authors: Van Horn JD,Toga AW

    更新日期:2009-10-01 00:00:00

  • Cortical activation to auditory mismatch elicited by frequency deviant and complex novel sounds: a PET study.

    abstract::The analysis of auditory deviant events outside the focus of attention is a fundamental capacity of human information processing and has been studied in experiments on Mismatch Negativity (MMN) and the P3a component in evoked potential research. However, generators contributing to these components are still under disc...


    pub_type: 临床试验,杂志文章


    authors: Müller BW,Jüptner M,Jentzen W,Müller SP

    更新日期:2002-09-01 00:00:00

  • Improved cortical-layer specificity of vascular space occupancy fMRI with slab inversion relative to spin-echo BOLD at 9.4 T.

    abstract::Cerebral blood volume (CBV)-weighted endogenous functional contrast can be obtained by the vascular space occupancy (VASO) technique. VASO relies on nonselective inversion for nulling blood signals, but the implementation of VASO at magnetic fields higher than 3 T is difficult due to converging T(1) values of tissue a...


    pub_type: 杂志文章


    authors: Jin T,Kim SG

    更新日期:2008-03-01 00:00:00

  • Whispering - The hidden side of auditory communication.

    abstract::Whispering is a unique expression mode that is specific to auditory communication. Individuals switch their vocalization mode to whispering especially when affected by inner emotions in certain social contexts, such as in intimate relationships or intimidating social interactions. Although this context-dependent whisp...


    pub_type: 杂志文章


    authors: Frühholz S,Trost W,Grandjean D

    更新日期:2016-11-15 00:00:00

  • A mini-cap for simultaneous EEG and fMRI recording in rodents.

    abstract::Simultaneous recording of electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) is now widely accepted as a prevailing tool to study brain functions. For over a decade, EEG caps with high-dense arrays of electrodes for EEG-fMRI studies in humans have been commercially available. However, simult...


    pub_type: 杂志文章


    authors: Sumiyoshi A,Riera JJ,Ogawa T,Kawashima R

    更新日期:2011-02-01 00:00:00

  • The anthropomorphic brain: the mirror neuron system responds to human and robotic actions.

    abstract::In humans and monkeys the mirror neuron system transforms seen actions into our inner representation of these actions. Here we asked if this system responds also if we see an industrial robot perform similar actions. We localised the motor areas involved in the execution of hand actions, presented the same subjects bl...


    pub_type: 杂志文章


    authors: Gazzola V,Rizzolatti G,Wicker B,Keysers C

    更新日期:2007-05-01 00:00:00

  • T2 quantification from only proton density and T2-weighted MRI by modelling actual refocusing angles.

    abstract::Proton density and transverse relaxation (T2)-weighted fast spin echo images are frequently acquired. T2 quantification is commonly performed by applying an exponential fit to these two images, despite recent evidence that an exponential fit is insufficient to correctly quantify T2 in the presence of imperfect RF refo...


    pub_type: 杂志文章


    authors: McPhee KC,Wilman AH

    更新日期:2015-09-01 00:00:00

  • Investigating the effect of blood susceptibility on phase contrast in the human brain.

    abstract::Recent work has shown a dramatic contrast between GM and WM in gradient echo phase images at high field (7 T). Although this contrast is key to the exploitation of phase in imaging normal and pathological tissue, its origin remains contentious. Several sources for this contrast have been considered including iron cont...


    pub_type: 杂志文章


    authors: Petridou N,Wharton SJ,Lotfipour A,Gowland P,Bowtell R

    更新日期:2010-04-01 00:00:00

  • Optimizing power to track brain degeneration in Alzheimer's disease and mild cognitive impairment with tensor-based morphometry: an ADNI study of 515 subjects.

    abstract::Tensor-based morphometry (TBM) is a powerful method to map the 3D profile of brain degeneration in Alzheimer's disease (AD) and mild cognitive impairment (MCI). We optimized a TBM-based image analysis method to determine what methodological factors, and which image-derived measures, maximize statistical power to track...


    pub_type: 杂志文章


    authors: Hua X,Lee S,Yanovsky I,Leow AD,Chou YY,Ho AJ,Gutman B,Toga AW,Jack CR Jr,Bernstein MA,Reiman EM,Harvey DJ,Kornak J,Schuff N,Alexander GE,Weiner MW,Thompson PM,Alzheimer's Disease Neuroimaging Initiative.

    更新日期:2009-12-01 00:00:00

  • Sex matters: Neural correlates of voice gender perception.

    abstract::The basis for different neural activations in response to male and female voices as well as the question, whether men and women perceive male and female voices differently, has not been thoroughly investigated. Therefore, the aim of the present study was to examine the behavioral and neural correlates of gender-relate...


    pub_type: 杂志文章


    authors: Junger J,Pauly K,Bröhr S,Birkholz P,Neuschaefer-Rube C,Kohler C,Schneider F,Derntl B,Habel U

    更新日期:2013-10-01 00:00:00

  • Macroscale variation in resting-state neuronal activity and connectivity assessed by simultaneous calcium imaging, hemodynamic imaging and electrophysiology.

    abstract::Functional imaging of spontaneous activity continues to play an important role in the field of connectomics. The most common imaging signal used for these experiments is the blood-oxygen-level-dependent (BOLD) functional MRI (fMRI) signal, but how this signal relates to spontaneous neuronal activity remains incomplete...


    pub_type: 杂志文章


    authors: Murphy MC,Chan KC,Kim SG,Vazquez AL

    更新日期:2018-04-01 00:00:00

  • Human reversal learning under conditions of certain versus uncertain outcomes.

    abstract::Reversal learning tasks assess behavioral flexibility by requiring subjects to switch from one learned response choice to a different response choice when task contingencies change. This requires both the processing of negative feedback once a learned response is no longer reinforced, and the capacity for flexible res...


    pub_type: 杂志文章


    authors: D'Cruz AM,Ragozzino ME,Mosconi MW,Pavuluri MN,Sweeney JA

    更新日期:2011-05-01 00:00:00

  • Comparator and non-comparator mechanisms of change detection in the context of speech--an ERP study.

    abstract::Automatic change detection reflects a cognitive memory-based comparison mechanism as well as a sensorial non-comparator mechanism based on differential states of refractoriness. The purpose of this study was to examine whether the comparator mechanism of the mismatch negativity component (MMN) is differentially affect...


    pub_type: 杂志文章


    authors: Laufer I,Negishi M,Constable RT

    更新日期:2009-01-15 00:00:00

  • Elevating intracranial pressure reverses the decrease in deoxygenated hemoglobin and abolishes the post-stimulus overshoot upon somatosensory activation in rats.

    abstract::BOLD fMRI localizes activated brain areas by measuring decreases of deoxygenated hemoglobin (deoxy-Hb) caused by neurovascular coupling. To date, it is unclear whether intracranial pressure (ICP) modifies deoxy-Hb signaling for brain mapping. In addition, ICP elevation can test whether the BOLD post-stimulus undershoo...


    pub_type: 杂志文章


    authors: Füchtemeier M,Leithner C,Offenhauser N,Foddis M,Kohl-Bareis M,Dirnagl U,Lindauer U,Royl G

    更新日期:2010-08-15 00:00:00

  • Elevated Neuroinflammation Contributes to the Deleterious Impact of Iron Overload on Brain Function in Aging.

    abstract::Intracellular iron is essential for many neurobiological mechanisms. However, at high concentrations, iron may induce oxidative stress and inflammation. Brain iron overload has been shown in various neurodegenerative disorders and in normal aging. Elevated brain iron in old age may trigger brain dysfunction and concom...


    pub_type: 杂志文章


    authors: Salami A,Papenberg G,Sitnikov R,Laukka EJ,Persson J,Kalpouzos G

    更新日期:2021-01-23 00:00:00

  • Statistical models for brain signals with properties that evolve across trials.

    abstract::Most neuroscience cognitive experiments involve repeated presentations of various stimuli across several minutes or a few hours. It has been observed that brain responses, even to the same stimulus, evolve over the course of the experiment. These changes in brain activation and connectivity are believed to be associat...


    pub_type: 杂志文章


    authors: Ombao H,Fiecas M,Ting CM,Low YF

    更新日期:2018-10-15 00:00:00

  • Imaging phonology without print: assessing the neural correlates of phonemic awareness using fMRI.

    abstract::Acquisition of phonological processing skills, such as the ability to segment words into corresponding speech sounds, is critical to the development of efficient reading. Prior neuroimaging studies of phonological processing have often relied on auditory stimuli or print-mediated tasks that may be problematic for vari...


    pub_type: 临床试验,杂志文章


    authors: Katzir T,Misra M,Poldrack RA

    更新日期:2005-08-01 00:00:00

  • Detection of functional connectivity in the resting mouse brain.

    abstract::Resting-state functional connectivity, manifested as spontaneous synchronous activity in the brain, has been detected by functional MRI (fMRI) across species such as humans, monkeys, and rats. Yet, most networks, especially the classical bilateral connectivity between hemispheres, have not been reliably found in the m...


    pub_type: 杂志文章


    authors: Nasrallah FA,Tay HC,Chuang KH

    更新日期:2014-02-01 00:00:00

  • Reflective self-awareness and conscious states: PET evidence for a common midline parietofrontal core.

    abstract::A recent meta-analysis has shown precuneus, angular gyri, anterior cingulate gyri, and adjacent structures to be highly metabolically active in support of resting consciousness. We hypothesize that these regions constitute a functional network of reflective self-awareness thought to be a core function of consciousness...


    pub_type: 临床试验,杂志文章


    authors: Kjaer TW,Nowak M,Lou HC

    更新日期:2002-10-01 00:00:00

  • Fast optical signal not detected in awake behaving monkeys.

    abstract::While the ability of near-infrared spectroscopy (NIRS) to measure cerebral hemodynamic evoked responses (slow optical signal) is well established, its ability to measure non-invasively the 'fast optical signal' is still controversial. Here, we aim to determine the feasibility of performing NIRS measurements of the 'fa...


    pub_type: 杂志文章


    authors: Radhakrishnan H,Vanduffel W,Deng HP,Ekstrom L,Boas DA,Franceschini MA

    更新日期:2009-04-01 00:00:00

  • The spatial distribution of age-related white matter changes as a function of vascular risk factors--results from the LADIS study.

    abstract::White matter hyperintensities (WMH) are a frequent finding on brain MRI of elderly subjects, and have been associated with various risk factors, as well as with development of cognitive and functional impairment. While an overall association between WMH load and risk factors is well described, possible spatially restr...


    pub_type: 杂志文章,多中心研究


    authors: Rostrup E,Gouw AA,Vrenken H,van Straaten EC,Ropele S,Pantoni L,Inzitari D,Barkhof F,Waldemar G,LADIS study group.

    更新日期:2012-04-15 00:00:00

  • Negative edges and soft thresholding in complex network analysis of resting state functional connectivity data.

    abstract::Complex network analyses of functional connectivity have consistently revealed non-random (modular, small-world, scale-free-like) behavior of hard-thresholded networks constructed from the right-tail of the similarity histogram. In the present study we determined network properties resulting from edges constrained to ...


    pub_type: 杂志文章


    authors: Schwarz AJ,McGonigle J

    更新日期:2011-04-01 00:00:00

  • Neuronal specificity of acupuncture response: a fMRI study with electroacupuncture.

    abstract::Recently, neuronal correlates of acupuncture stimulation in human brain have been investigated by functional neuroimaging. The preliminary findings suggest that acupuncture at analgesic points involves the pain-related neuromatrix and may have acupoint-brain correlation. Although multiple models of control stimulation...


    pub_type: 杂志文章


    authors: Wu MT,Sheen JM,Chuang KH,Yang P,Chin SL,Tsai CY,Chen CJ,Liao JR,Lai PH,Chu KA,Pan HB,Yang CF

    更新日期:2002-08-01 00:00:00

  • White matter alterations to cingulum and fornix following very preterm birth and their relationship with cognitive functions.

    abstract::Very preterm birth (VPT; <32 weeks of gestation) has been associated with impairments in memory abilities and functional neuroanatomical brain alterations in medial temporal and fronto-parietal areas. Here we investigated the relationship between structural connectivity in memory-related tracts and various aspects of ...


    pub_type: 杂志文章


    authors: Caldinelli C,Froudist-Walsh S,Karolis V,Tseng CE,Allin MP,Walshe M,Cuddy M,Murray RM,Nosarti C

    更新日期:2017-04-15 00:00:00

  • Negative words enhance recognition in nonclinical high dissociators: An fMRI study.

    abstract::Memory encoding and retrieval were studied in a nonclinical sample of participants that differed in the amount of reported dissociative experiences (trait dissociation). Behavioral as well as functional imaging (fMRI) indices were used as convergent measures of memory functioning. In a deep vs. shallow encoding paradi...


    pub_type: 杂志文章


    authors: de Ruiter MB,Veltman DJ,Phaf RH,van Dyck R

    更新日期:2007-08-01 00:00:00

  • MR microscopy of rat hippocampal slice cultures: a novel model for studying cellular processes and chronic perturbations to tissue microstructure.

    abstract::Brain slices provide a useful nervous tissue model to investigate the relationships between magnetic resonance imaging (MRI) contrast mechanisms and tissue microstructure; yet, these acutely isolated tissues remain viable for only 10-12 h. To study slower biological processes, this work describes the first MRI microsc...


    pub_type: 杂志文章


    authors: Shepherd TM,Scheffler B,King MA,Stanisz GJ,Steindler DA,Blackband SJ

    更新日期:2006-04-15 00:00:00

  • A comparison of various MRI feature types for characterizing whole brain anatomical differences using linear pattern recognition methods.

    abstract::There is a widespread interest in applying pattern recognition methods to anatomical neuroimaging data, but so far, there has been relatively little investigation into how best to derive image features in order to make the most accurate predictions. In this work, a Gaussian Process machine learning approach was used f...


    pub_type: 杂志文章


    authors: Monté-Rubio GC,Falcón C,Pomarol-Clotet E,Ashburner J

    更新日期:2018-09-01 00:00:00