ST-deviation reconstruction in missing leads on the 12-lead ECG: applicability in studies on ST-segment resolution during thrombolysis.

Abstract:

:Quantitative analysis of ST-segment deviations (STdev) and their resolution by treatment (STR; calculated from a combined sum of STdev in multiple leads) are used in trials on reperfusion for myocardial infarction (MI). Unreadable or unavailable electrocardiogram (ECG) leads are a common reason for exclusion, decreasing the statistical power of the trials. We developed mathematical formulas for reconstruction of immeasurable STdev based on STdev from other available leads on the 12-lead ECG. Formulas were deducted from a database of computer-assisted STdev measurements in 2 ECGs (baseline and 180 min after thrombolysis) of 1121 pts. Their accuracy was later evaluated on a second dataset of 377 pts. Acceptable fits could be derived for absent single leads, or for groups of absent limb leads (I-II-III or aVL-aVF). The intraclass correlation coefficient between real and calculated STdev was >or= 0.80 for each (0.77 for V1 in inferior MI). The correlations between STR calculated from original data and from reconstructed STdev were very strong (all intraclass correlation >or=0.97), and discordance in STR subgroup categorization occurred in

journal_name

J Electrocardiol

authors

Kaluzay J,Vandenberghe K,Fontaine D,Herbots L,Anné W,Van de Werf F,Heidbüchel H

doi

10.1016/s0022-0736(03)00030-x

keywords:

subject

Has Abstract

pub_date

2003-07-01 00:00:00

pages

187-93

issue

3

eissn

0022-0736

issn

1532-8430

pii

aS002207360300030X

journal_volume

36

pub_type

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