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(S)-N-[1-(3-morpholin-4-ylphenyl)ethyl]- 3-phenylacrylamide: an orally bioavailable KCNQ2 opener with significant activity in a cortical spreading depression model of migraine.

Abstract：

:(S)-N-[1-(3-Morpholin-4-ylphenyl)ethyl]-3-phenylacrylamide (2) was synthesized as an orally bioavailable KCNQ2 potassium channel opener. In a rat model of migraine, 2 demonstrated significant oral activity in reducing the total number of cortical spreading depressions induced by potassium chloride.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Wu YJ,Boissard CG,Greco C,Gribkoff VK,Harden DG,He H,L'Heureux A,Kang SH,Kinney GG,Knox RJ,Natale J,Newton AE,Lehtinen-Oboma S,Sinz MW,Sivarao DV,Starrett JE Jr,Sun LQ,Tertyshnikova S,Thompson MW,Weaver D,Wong HS

doi

10.1021/jm034073f

keywords:

subject

Has Abstract

pub_date

2003-07-17 00:00:00

pages

3197-200

issue

15

eissn

0022-2623

issn

1520-4804

journal_volume

46

pub_type

杂志文章

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