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Evaluation of carbon-11-labeled 2beta-carbomethoxy-3beta-[4'-((Z)-2-iodoethenyl)phenyl]nortropane as a potential radioligand for imaging the serotonin transporter by PET.

Abstract：

:The nortropane cocaine analogue, 2beta-carbomethoxy-3beta-[4'-((Z)-2-iodoethenyl)phenyl]nortropane (ZIENT), is a high affinity, selective serotonin transporter (SERT) ligand that has shown promise as a SERT imaging agent for single photon computed tomography (SPECT) when labeled with I-123. Synthesis of the labeling precursor, radiosynthesis of [(11)C]ZIENT, and in vivo evaluation in anesthetized and awake monkeys have been performed to determine the suitability of [(11)C]ZIENT as a PET agent for SERT imaging.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Plisson C,Jarkas N,McConathy J,Voll RJ,Votaw J,Williams L,Howell LL,Kilts CD,Goodman MM

doi

10.1021/jm050799v

keywords:

subject

Has Abstract

pub_date

2006-02-09 00:00:00

pages

942-6

issue

3

eissn

0022-2623

issn

1520-4804

journal_volume

49

pub_type

杂志文章

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