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Structure-activity relationships of imidazo[4,5-f]quinoline partial structures and analogs. Discovery of pyrazolo[3,4-f]quinoline derivatives as potent immunostimulants.

Abstract：

:Structure-activity studies have been carried out on a series of imidazo[4,5-f]quinoline derivatives reported to have potent in vivo immunostimulatory activity. This activity has been confirmed, and subtle structure-activity relationships have been uncovered which resulted in the identification of novel analogs (pyrazolo[3,4-f]quinoline derivatives, 7a,b) with potent in vivo effects in a mouse protection model. Regioisomeric pyrazolo[4,3-f]quinoline derivatives (6a,b) were shown to be inactive. Data are presented which support the notion that the in vivo activity is mediated by an immunostimulatory mechanism.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Moyer MP,Weber FH,Gross JL

doi

10.1021/jm00102a013

keywords:

subject

Has Abstract

pub_date

1992-11-27 00:00:00

pages

4595-601

issue

24

eissn

0022-2623

issn

1520-4804

journal_volume

35

pub_type

杂志文章

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