Abstract:
:1. The aim of the present study was to produce a mathematical model that describes the way dynamic changes in renal sympathetic nerve activity affect renal, cortical and medullary blood flow. 2. Cortical blood flow (CBF) and medullary blood flow (MBF) were measured using laser-Doppler flowmetry and (total) renal blood flow (RBF) was measured by transit-time flowmetry in six pentobarbitone-anaesthetized rabbits. The renal nerves were stimulated with rectangular pulses of 2 msec width and constant voltage at frequencies of 0.5, 1, 1.5, 2 and 3 Hz. 3. An exponential function with two parameters was applied; steady state gain and a dynamic constant for the blood flow reduction with stimulation. The steady state gain coefficients were similar for RBF and CBF, but significantly less for MBF. The time taken to reach minimum flow was less for MBF than for RBF and CBF. 4. The model parameters indicate that there is differential neural control of CBF and MBF.
journal_name
Clin Exp Pharmacol Physioljournal_title
Clinical and experimental pharmacology & physiologyauthors
Navakatikyan MA,Leonard BL,Evans RG,Malpas SCdoi
10.1046/j.1440-1681.2000.03298.xkeywords:
subject
Has Abstractpub_date
2000-08-01 00:00:00pages
650-2issue
8eissn
0305-1870issn
1440-1681journal_volume
27pub_type
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