Modelling the neural control of intrarenal blood flow.

Abstract:

:1. The aim of the present study was to produce a mathematical model that describes the way dynamic changes in renal sympathetic nerve activity affect renal, cortical and medullary blood flow. 2. Cortical blood flow (CBF) and medullary blood flow (MBF) were measured using laser-Doppler flowmetry and (total) renal blood flow (RBF) was measured by transit-time flowmetry in six pentobarbitone-anaesthetized rabbits. The renal nerves were stimulated with rectangular pulses of 2 msec width and constant voltage at frequencies of 0.5, 1, 1.5, 2 and 3 Hz. 3. An exponential function with two parameters was applied; steady state gain and a dynamic constant for the blood flow reduction with stimulation. The steady state gain coefficients were similar for RBF and CBF, but significantly less for MBF. The time taken to reach minimum flow was less for MBF than for RBF and CBF. 4. The model parameters indicate that there is differential neural control of CBF and MBF.

authors

Navakatikyan MA,Leonard BL,Evans RG,Malpas SC

doi

10.1046/j.1440-1681.2000.03298.x

keywords:

subject

Has Abstract

pub_date

2000-08-01 00:00:00

pages

650-2

issue

8

eissn

0305-1870

issn

1440-1681

journal_volume

27

pub_type

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