Bfl-1 gene expression in breast cancer: its relationship with other prognostic factors.

Abstract:

:The Bfl-1 gene, which was isolated from human fetal liver and only recently described, is a member of the Bcl-2 gene family. Reverse transcriptase-polymerase chain reaction was performed on RNA drawn from 30 breast cancer tissues to compare the expression of the Bfl-1 gene with other prognostic factors. The median relative ratio was 3.0 (range, 0.12-26.83) and the Bfl-1 gene expression rate was 36.7% (11/30). There was no statistically significant relationship between the clinicopathologic parameters of patients and the expression value of Bfl-1 gene. The level of Bfl-1 gene expression was higher in more advanced breast cancers than in early cancers. There was no significant relationship between the expression values and currently acknowledged prognostic factors, but a higher expression pattern was noticed in the groups of positive hormone receptors and negative p53 and negative c-erbB2, albeit statistically not significant. It seems that the increased expression of the Bfl-1 gene serves as a contributory factor in breast cancer, in the same way that another group of genes, the Bcl-2 family, contributes to apoptosis.

journal_name

J Korean Med Sci

authors

Yoon HS,Hong SH,Kang HJ,Ko BK,Ahn SH,Huh JR

doi

10.3346/jkms.2003.18.2.225

keywords:

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

225-30

issue

2

eissn

1011-8934

issn

1598-6357

pii

200304225

journal_volume

18

pub_type

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