Subcutaneous plasmacytomas with tropism to sites of previous trauma in a multiple myeloma patient treated with an autologous bone marrow transplant.

abstract：:The clinical features of patients with splenic marginal zone cell lymphoma (SMZCL) have rarely been reported. In the present study, immunological abnormalities, particularly hematological abnormalities, observed in SMZCL were described. Autoimmune hemolytic anemia, immune thrombocytopenia, and appearance of lupus anti...

journal_title：American journal of hematology

authors： Murakami H,Irisawa H,Saitoh T,Matsushima T,Tamura J,Sawamura M,Karasawa M,Hosomura Y,Kojima M

更新日期：1997-11-01 00:00:00

abstract：:Although large vessel thrombi are occasionally reported in patients with homozygous sickle cell disease, the role of intravascular coagulation in typical pain crises is controversial. Therefore, we studied 24 sickle cell patients during and between episodes of pain crisis, using several sensitive tests of hemostasis. ...

journal_title：American journal of hematology

authors： Green D,Scott JP

更新日期：1986-12-01 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (HSCT) represents the only curative option for primary hemophagocytic lymphohistiocytosis (HLH), a rare disease of infants and young children, characterized by recurrent fever, hepatosplenomegaly, and cytopenia. We report a case of successful engraftment and stable fu...

journal_title：American journal of hematology

authors： Cesaro S,Gazzola MV,Marson P,Calore E,Caenazzo L,Destro R,De Silvestro G,Varotto S,Pillon M,Zanesco L,Messina C

更新日期：2003-02-01 00:00:00

abstract：:Intravenous morphine is the treatment of choice for severe pain during vaso- occlusive crisis in sickle cell disease (SCD). However, side effects of morphine may hamper effective treatment, and high plasma levels of morphine are associated with severe complications such as acute chest syndrome. Furthermore, adequate d...

journal_title：American journal of hematology

authors： van Beers EJ,van Tuijn CF,Nieuwkerk PT,Friederich PW,Vranken JH,Biemond BJ

更新日期：2007-11-01 00:00:00

abstract：:As the number of anticoagulant drugs increases and new ones are brought to market, the utility of the routine screening coagulation tests of today--namely the prothrombin time and activated partial thromboplastin time--will be significantly reduced in many clinical situations. Although the new anticoagulants are desig...

journal_title：American journal of hematology

authors： Gehrie E,Laposata M

更新日期：2012-02-01 00:00:00

abstract：:Sickle cell disease (SCD) nephropathy and lower estimated glomerular filtration rate (eGFR) are risk factors for early mortality. Furthermore, rate of eGFR decline predicts progression to end-stage renal disease in many clinical settings. However, factors predicting renal function decline in SCD are poorly documented....

journal_title：American journal of hematology

authors： Xu JZ,Garrett ME,Soldano KL,Chen ST,Clish CB,Ashley-Koch AE,Telen MJ

更新日期：2018-12-01 00:00:00

abstract：:The case of a 21 year-old female with echinocytosis and a littoral cell hemangioma is reported. The patient had no significant past medical history and presented with abdominal pain and splenomegaly. A large percentage of echinocytes were noted on her peripheral smear in the absence of any known causes. A CT-recognize...

journal_title：American journal of hematology

authors： Altomare I,Desman G,Aledort LM

更新日期：2006-07-01 00:00:00

abstract：:Serologic diagnosis for Epstein-Barr virus (EBV) infection is problematic when patients receive exogenous immunoglobulin. We recently diagnosed primary EBV infection by detecting EBV-determined nuclear antigen (EBNA) and EBV-DNA in peripheral blood mononuclear cells (PBMC) using immunofluorescence, in situ hybridizati...

journal_title：American journal of hematology

authors： Okano M,Bashir RM,Davis JR,Purtilo DT

更新日期：1991-04-01 00:00:00

abstract：:A 28-year-old asymptomatic male of Iranian Jewish (Meshadi) heritage was found on routine exam to have an erythrocytosis (RBC = 6.22 x 10(12)/l, Hgb = 19.2 g/dl, Hct = 58.9%). Splenomegaly was absent on physical exam. There was no family history of erythrocytosis. His oxygen dissociation curve was left-shifted with a ...

journal_title：American journal of hematology

authors： Hoyer JD,Allen SL,Beutler E,Kubik K,West C,Fairbanks VF

更新日期：2004-04-01 00:00:00

abstract：:Platelet antibodies are detectable in only about 50% of patients with chronic autoimmune thrombocytopenia (AITP). We determined platelet antibodies against GPIa/IIa, GPIb/IX, GPIIb/IIIa, and GPV and reticulated platelets in three female patients with AITP, before and after immunoadsorption treatment. None of the three...

journal_title：American journal of hematology

authors： Leitner GC,Stiegler G,Horvath M,Hoecker P,Sagaster P,Panzer S

更新日期：2003-05-01 00:00:00

abstract：:In the current study, we investigated C/EBPA gene mutations and promoter hypermethylation in a series of 53 patients with CN-AML. In addition, we also analyzed two other frequent mutations (FLT3/ITD and NPM1) in these patients and correlated them with C/EBPA gene alterations. 13/53 patients were FLT3/ITD+/NPM1-, 11/53...

journal_title：American journal of hematology

authors： Lu Y,Chen W,Chen W,Stein A,Weiss LM,Huang Q

更新日期：2010-06-01 00:00:00

abstract：:Vascular complications are the main cause of morbidity in diabetes mellitus. To evaluate lipoprotein and hemostatic parameters and their relationship with clinically detectable microangiopathy, we studied 58 insulin-dependent diabetes mellitus patients and 60 controls matched for age, sex, and body mass index. Thirtee...

journal_title：American journal of hematology

authors： Reverter JL,Reverter JC,Tàssies D,Rius F,Monteagudo J,Rubiés-Prat J,Escolar G,Ordinas A,Sanmarti A

更新日期：1997-10-01 00:00:00

abstract：:Therapies engineered to prolong clotting factor protein circulation time, manipulate the balance of pro-coagulant and anti-coagulant proteins, or introduce new genetic material to enable endogenous factor protein production dominate the clinical trial landscape of hemophilia. The availability of clotting factor concen...

journal_title：American journal of hematology

authors： Croteau SE,Wang M,Wheeler AP

更新日期：2021-01-01 00:00:00

abstract：:Evidence suggest that even patients aged 70 or above benefit from specific AML therapy. The fundamental decision in AML then becomes whether to recommend standard or investigational treatment. This decision must rest on the likely outcome of standard treatment. Hence we review factors that predict treatment related mo...

journal_title：American journal of hematology

authors： Estey E

更新日期：2016-08-01 00:00:00

abstract：:Hydroxyurea is a drug that is used to treat some patients with sickle cell disease. We have measured the deformability of sickle erythrocytes incubated in hydroxyurea in vitro and found that hydroxyurea acts to decrease the deformability of these cells. The deformability of normal erythrocytes was not significantly af...

journal_title：American journal of hematology

authors： Huang Z,Louderback JG,King SB,Ballas SK,Kim-Shapiro DB

更新日期：2001-07-01 00:00:00

abstract：:Lenalidomide and azacitidine are active in MDS patients, and may complement each other by targeting the bone marrow microenvironment and the malignant clone. A recent Phase I trial testing the lenalidomide and azacitidine combination yielded encouraging results; however, lenalidomide’s contribution was unclear. In thi...

journal_title：American journal of hematology

authors： Sekeres MA,O'Keefe C,List AF,Paulic K,Afable M 2nd,Englehaupt R,Maciejewski JP

更新日期：2011-01-01 00:00:00

abstract：:The human spleen normally retains about one-third of the body's platelets in an exchangeable pool which can be released into the circulation by alpha-adrenergic stimulation. Some previous investigators concluded that the splenic platelet population was enriched in a subpopulation of large, young, dense platelets (mega...

journal_title：American journal of hematology

authors： Chamberlain KG,Tong M,Penington DG

更新日期：1990-07-01 00:00:00

abstract：:Philadelphia chromosome (Ph1) positive, or "adult-type," chronic granulocytic leukemia (CGL) differs in many clinical and laboratory aspects from PH1-negative, or "juvenile," CGL. Because of these differences, the disorders have been considered two distinct disease entities. We present a child with Ph1-positive CGL wh...

journal_title：American journal of hematology

authors： Gay JC,Dessypris EN,Roloff JS,Lukens JN

更新日期：1984-01-01 00:00:00

abstract：:Iron refractory iron deficiency anemia (IRIDA) is a rare hereditary disease caused by mutations in TMPRSS6 gene encoding Matriptase-2, a negative regulator of hepcidin transcription. Up to now, 53 IRIDA patients from 35 families with different ethnic origins have been reported and 41 TMPRSS6 mutations have been identi...

journal_title：American journal of hematology

authors： Poggiali E,Andreozzi F,Nava I,Consonni D,Graziadei G,Cappellini MD

更新日期：2015-04-01 00:00:00

abstract：:ABO incompatibility is commonly observed in stem cell transplantation and its impact in this setting has been extensively investigated. HLA-mismatched unrelated donors (MMURD) are often used as an alternative stem cell source but are associated with increased transplant related complications. Whether ABO incompatibili...

journal_title：American journal of hematology

authors： Canaani J,Savani BN,Labopin M,Michallet M,Craddock C,Socié G,Volin L,Maertens JA,Crawley C,Blaise D,Ljungman PT,Cornelissen J,Russell N,Baron F,Gorin N,Esteve J,Ciceri F,Schmid C,Giebel S,Mohty M,Nagler A

更新日期：2017-08-01 00:00:00

abstract：:Monoclonal B-cell lymphocytosis (MBL) with normal lymphocyte counts is associated with decreased numbers of normal circulating B-cell subsets.Little is known about the distribution of normal lymphoid cells and their subsets in the peripheral blood (PB) of subjects with monoclonal B-cell lymphocytosis (MBL). In our stu...

journal_title：American journal of hematology

authors： Hauswirth AW,Almeida J,Nieto WG,Teodosio C,Rodriguez-Caballero A,Romero A,López A,Fernandez-Navarro P,Vega T,Perez-Andres M,Valent P,Jäger U,Orfao A,Primary Health Care Group of Salamanca for Study of MBL.

更新日期：2012-07-01 00:00:00

abstract：:Recent advances in massively parallel sequencing technologies have provided a detailed picture of the mutational landscape in CLL and underscored the vast degree of interpatient and intratumor heterogeneities. These studies have led to the characterization of novel putative driver genes and recurrently affected biolog...

journal_title：American journal of hematology

authors： Roos-Weil D,Nguyen-Khac F,Bernard OA

更新日期：2016-05-01 00:00:00

abstract：:A 63-year-old white man with myasthenia gravis and red cell aplasia was found to have hepatic iron overload. The differential diagnosis included hereditary hemochromatosis and secondary iron overload related to red cell aplasia. Family studies of siblings, including HLA typing, initially suggested a diagnosis of secon...

journal_title：American journal of hematology

authors： Adams PC

更新日期：1994-03-01 00:00:00

abstract：:Immune thrombocytopenia is frequently encountered in medical practice and is generally accepted as being caused by an IgG antibody. The capability of detecting platelet-bound IgG as a diagnostic and therapeutic modality is critical for appropriate care and management of patients with idiopathic thrombocytopenic purpur...

journal_title：American journal of hematology

authors： Tate DY,Carlton GT,Nesbit ME,White JG,Krivit W,Sorenson RL

更新日期：1980-01-01 00:00:00

abstract：:We report a patient with incapacitating POEMS syndrome characterized by serum monoclonal protein, polyneuropathy, organomegaly, endocrinopathy, mesangiocapillary glomerulonephritis, massive ascites formation, and pulmonary hypertension. A dramatic improvement in the clinical condition occurred after administration of ...

journal_title：American journal of hematology

authors： Sinisalo M,Hietaharju A,Sauranen J,Wirta O

更新日期：2004-05-01 00:00:00

abstract：:Vascular complications, including pulmonary hypertension (PH), have been reported to occur following splenectomy for various disorders,including hereditary spherocytosis (HS). We performed a prospective cross-sectional study of 36 adults with HS (78% with prior splenectomy)utilizing echocardiography to estimate tricus...

journal_title：American journal of hematology

authors： Crary SE,Ramaciotti C,Buchanan GR

更新日期：2011-12-01 00:00:00

abstract：:The content of peripheral blood B cells (B1+) was reduced in patients of multiple myeloma (MM) and not in those with benign monoclonal gammopathy (BMG) compared to normal donors (P less than 0.01). This observation correlated with the suppression of synthesis of normal immunoglobulin (Ig) in MM. Thus, cytokine activit...

journal_title：American journal of hematology

authors： Kawano M,Iwato K,Asaoku H,Tanabe O,Tanaka H,Ishikawa H,Kuramoto A

更新日期：1989-02-01 00:00:00

abstract：:Clopidogrel is a widely used antiplatelet agent that irreversibly inhibits platelet P2Y12 ADP receptors after conversion to an active metabolite. There are a number of laboratory tests capable of detecting clopidogrel-induced platelet inhibition and published literature correlates suboptimal clopidogrel response to ad...

journal_title：American journal of hematology

authors： Smock KJ,Saunders PJ,Rodgers GM,Johari V

更新日期：2011-12-01 00:00:00

abstract：:Multiple myeloma (MM) and primary systemic light chain amyloidosis (AL) are both chronic plasma cell dyscrasias with different clinical expression but limited treatment options for relapsed refractory disease. We report the effect of the addition of clarithromycin on 31 MM and 17 AL with relapsed or refractory disease...

journal_title：American journal of hematology

authors： Shaulov A,Ganzel C,Benyamini N,Barshay Y,Goldschmidt N,Lavie D,Libster D,Gural A,Avni B,Gatt ME

更新日期：2017-02-01 00:00:00

abstract：:Thromboembolic complications following splenectomy for hematologic diseases occur in up to 10% of patients and may range from portal vein thrombosis (PVT) to pulmonary embolism (PE) and deep vein thrombosis (DVT). Up to now there exist no recommendations for the duration and intensity of prophylactic anticoagulation, ...

journal_title：American journal of hematology

authors： Mohren M,Markmann I,Dworschak U,Franke A,Maas C,Mewes S,Weiss G,Jentsch-Ullrich K

更新日期：2004-06-01 00:00:00