Hereditary hemochromatosis and red cell aplasia.

abstract：:Transformation to secondary myelofibrosis (MF) occurs as part of the natural history of polycythemia vera (PPV-MF) and essential thrombocythemia (PET-MF). Although primary (PMF) and secondary MF are considered similar diseases and managed similarly, there are few studies specifically focused on the latter. The aim of ...

journal_title：American journal of hematology

authors： Rotunno G,Pacilli A,Artusi V,Rumi E,Maffioli M,Delaini F,Brogi G,Fanelli T,Pancrazzi A,Pietra D,Bernardis I,Belotti C,Pieri L,Sant'Antonio E,Salmoiraghi S,Cilloni D,Rambaldi A,Passamonti F,Barbui T,Manfredini R,Ca

更新日期：2016-07-01 00:00:00

abstract：:This report describes studies investigating the use of a collagen binding assay to improve the laboratory monitoring of desmopressin (DDAVP) therapy in patients with von Willebrand's disease (vWD). We evaluated the response of seven patients with vWD (four type I, three type IIA) to DDAVP, administered using a standar...

journal_title：American journal of hematology

authors： Favaloro EJ,Dean M,Grispo L,Exner T,Koutts J

更新日期：1994-03-01 00:00:00

abstract：:Cytotoxic agents like Hydroxyurea, Busulfan and Interferon-alpha are to date the most commonly used therapeutic approaches in Essential Thrombocythemia (ET). However, few data on the efficacy and safety of these agents in the long-term are currently available. We report a retrospective analysis of the long-term outcom...

journal_title：American journal of hematology

authors： Palandri F,Catani L,Testoni N,Ottaviani E,Polverelli N,Fiacchini M,De Vivo A,Salmi F,Lucchesi A,Baccarani M,Vianelli N

更新日期：2009-04-01 00:00:00

abstract：:Polycythemia vera (PV) and essential thrombocythemia (ET) are common types of myeloproliferative disorders (MPD), the prevalence of which has not been well documented in the United States. Recent breakthroughs in the molecular etiology of these disorders and the accelerated development of targeted pharmacotherapeutics...

journal_title：American journal of hematology

authors： Ma X,Vanasse G,Cartmel B,Wang Y,Selinger HA

更新日期：2008-05-01 00:00:00

abstract：:Venous thromboembolism (VTE) is a common cause of morbidity and mortality among patients with multiple myeloma (MM). The International Myeloma Working Group (IMWG) developed guidelines recommending primary thromboprophylaxis, in those identified at high-risk of VTE by the presence of risk factors. The National Compreh...

journal_title：American journal of hematology

authors： Sanfilippo KM,Luo S,Wang TF,Fiala M,Schoen M,Wildes TM,Mikhael J,Kuderer NM,Calverley DC,Keller J,Thomas T,Carson KR,Gage BF

更新日期：2019-11-01 00:00:00

abstract：:Although large vessel thrombi are occasionally reported in patients with homozygous sickle cell disease, the role of intravascular coagulation in typical pain crises is controversial. Therefore, we studied 24 sickle cell patients during and between episodes of pain crisis, using several sensitive tests of hemostasis. ...

journal_title：American journal of hematology

authors： Green D,Scott JP

更新日期：1986-12-01 00:00:00

abstract：DISEASE OVERVIEW:Hodgkin lymphoma (HL) is an uncommon B-cell lymphoid malignancy affecting 8500 new patients annually and representing approximately 10.2% of all lymphomas in the United States. DIAGNOSIS:HL is composed of two distinct disease entities: classical HL and nodular lymphocyte predominant HL. Nodular sclero...

journal_title：American journal of hematology

authors： Ansell SM

更新日期：2018-05-01 00:00:00

abstract：:Thalassemia is an inherited blood disorder that requires lifelong adherence to a complicated and burdensome medical regimen which could potentially impact emotional functioning of patients. The importance of understanding and promoting healthy emotional functioning is crucial not only to psychological well-being, but ...

journal_title：American journal of hematology

authors： Mednick L,Yu S,Trachtenberg F,Xu Y,Kleinert DA,Giardina PJ,Kwiatkowski JL,Foote D,Thayalasuthan V,Porter JB,Thompson AA,Schilling L,Quinn CT,Neufeld EJ,Yamashita R,Thalassemia Clinical Research Network.

更新日期：2010-10-01 00:00:00

abstract：:We present a female patient with T-gamma LGL leukemia, who was followed for the last 20 years. Over these years she developed several autoimmune disorders, including Sjögren's syndrome, Hashimoto's thyroiditis, premature ovarian failure (compatible with type II autoimmune polyglandular syndrome), amegakaryocytic throm...

journal_title：American journal of hematology

authors： Ergas D,Tsimanis A,Shtalrid M,Duskin C,Berrebi A

更新日期：2002-02-01 00:00:00

abstract：:Conventional treatment of mantle cell lymphoma (MCL) yields modest responses and short remissions. We report 30 hematopoietic stem cell transplants (HSCT) for MCL: 13 autologous, 10 allogeneic myeloablative, and 7 nonablative. After a median 1.2 years from diagnosis (range 0.5 to 4.7) and a median of 2 pre-HSCT chemot...

journal_title：American journal of hematology

authors： Laudi N,Arora M,Burns L,McGlave P,Miller J,Bohac G,Rogers T,Barker J,Coad J,Weisdorf D

更新日期：2006-07-01 00:00:00

abstract：:Several histone deacetylase inhibitors (HDACi), including vorinostat, have been approved for the therapy of cutaneous T-cell lymphoma (CTCL). Emerging data suggest that HDACi may exert immune suppressive effects which would be disadvantageous for therapy of CTCL. We describe a patient with Sezary syndrome who was moni...

journal_title：American journal of hematology

authors： Stephen S,Morrissey KA,Benoit BM,Kim EJ,Vittorio CC,Nasta SD,Showe LC,Wysocka M,Rook AH

更新日期：2012-02-01 00:00:00

abstract：:The erythrocytes of 90 pregnant women were evaluated for the presence of in vivo or in vitro oxidant damage. The reduced glutathione (P less than 0.005) and the membrane reduced sulfhydryl (P less than 0.001) concentrations were decreased in fresh erythrocytes. Following incubation with acetylphenylhydrazine, Heinz bo...

journal_title：American journal of hematology

authors： Lachant NA,Gottlieb AJ,DiFino SM,Landaw SA,Tanaka KR

更新日期：1985-02-01 00:00:00

abstract：:A 1750 base pair cDNA to human terminal deoxynucleotidyl transferase (TdT) has been cloned. This cDNA detects a dominant 2200 base pair messenger RNA species in normal and leukemic cells synthesizing the enzyme. A quantitative dot blot assay was utilized to survey a number of clinical samples from patients with TdT po...

journal_title：American journal of hematology

authors： Wolf SC,Steinherz PG,Landau NR,Silverstone AE

更新日期：1987-07-01 00:00:00

abstract：:Children with sickle cell anemia (SCA) and a primary overt stroke are at high risk of recurrent (secondary) stroke. Chronic transfusion therapy dramatically reduces but does not eliminate this high risk, and inevitably results in transfusion-related hemosiderosis. We previously reported the use of hydroxyurea/phleboto...

journal_title：American journal of hematology

authors： Greenway A,Ware RE,Thornburg CD

更新日期：2011-04-01 00:00:00

abstract：:The objective of the study was to explore the risks and benefits of splenectomy in advanced agnogenic myeloid metaplasia (AMM). We searched the literature (Medline, 1970-1987) for studies of postoperative survival, operative mortality and effects of splenectomy on painful splenomegaly, and portal hypertension or trans...

journal_title：American journal of hematology

authors： Benbassat J,Gilon D,Penchas S

更新日期：1990-02-01 00:00:00

abstract：:Autoantibody production following allogeneic stem-cell transplantation is common and is often ascribed to the immune dysregulation associated with graft-versus-host disease. Recent data suggests that donor-memory B cells can be reactivated on exposure to antigen and result in antibody production in the recipient ident...

journal_title：American journal of hematology

authors： Ritchie DS,Sainani A,D'Souza A,Grigg AP

更新日期：2005-08-01 00:00:00

abstract：DISEASE OVERVIEW:Waldenström macroglobulinemia (WM) is a lymphoplasmacytic lymphoma with immunoglobulin M (IgM) monoclonal protein. Clinical features include anemia, thrombocytopenia, hepatosplenomegaly, and lymphadenopathy. DIAGNOSIS:Presence of IgM monoclonal protein associated with 10% clonal lymphoplasmacytic cell...

journal_title：American journal of hematology

authors： Gertz MA

更新日期：2011-05-01 00:00:00

abstract：:Zoledronic acid (ZOL), an intravenous bisphosphonate, has been shown to reduce and delay the incidence of skeletal-related events (SREs) in multiple myeloma (MM) patients with bone disease. A retrospective claims-based analysis was conducted that used two distinct US managed care databases to examine the relationship ...

journal_title：American journal of hematology

authors： Henk HJ,Teitelbaum A,Perez JR,Kaura S

更新日期：2012-05-01 00:00:00

abstract：:Thrombotic complications occur at high rates in hospitalized patients with COVID-19, yet the impact of intensive antithrombotic therapy on mortality is uncertain. We examined in-hospital mortality with intermediate- compared to prophylactic-dose anticoagulation, and separately with in-hospital aspirin compared to no a...

journal_title：American journal of hematology

authors： Meizlish ML,Goshua G,Liu Y,Fine R,Amin K,Chang E,DeFilippo N,Keating C,Liu Y,Mankbadi M,McManus D,Wang SY,Price C,Bona RD,Ochoa Chaar CI,Chun HJ,Pine AB,Rinder HM,Siner JM,Neuberg DS,Owusu KA,Lee AI

更新日期：2021-01-21 00:00:00

abstract：:Splenectomy is a time-honoured well established approach for patients with steroid-resistant immune thrombocytopenia (ITP). However, due to the more recent availability of therapeutic options alternative to splenectomy, such as rituximab and agonists of the thrombopoietin-receptor, the choice of second-line therapy is...

journal_title：American journal of hematology

authors： Palandri F,Polverelli N,Catani L,Sollazzo D,Romano M,Levorato M,Vianelli N

更新日期：2014-11-01 00:00:00

abstract：:This report describes the bone marrow findings in four patients whose marrow was involved by anaplastic large-cell Ki-1 lymphoma, an uncommon event in this type of lymphoma. In the marrow aspirate smears, the involvement was subtle, and was in the form of isolated large cells with irregular nuclear configuration, coar...

journal_title：American journal of hematology

authors： Wong KF,Chan JK,Ng CS,Chu YC,Lam PW,Yuen HL

更新日期：1991-06-01 00:00:00

abstract：:To better assess the efficacy and safety of rituximab in adults' warm antibody autoimmune hemolytic anemia (wAIHA), we conducted a retrospective study including 27 adults (mean age 49.7 +/- 21 years) with either primary (n = 17) or secondary (n = 10) wAIHA. On average, the patients received 2.1 +/- 1.4 treatment lines...

journal_title：American journal of hematology

authors： Bussone G,Ribeiro E,Dechartres A,Viallard JF,Bonnotte B,Fain O,Godeau B,Michel M

更新日期：2009-03-01 00:00:00

abstract：:Seventeen adults received the antifibrinolytic drug tranexamic acid during cardiac surgery utilizing extracorporeal circulation (ECC). In 8 patients, drug administration began prior to skin incision (pre-ECC); infusions commenced after ECC and protamine administration in another 9 patients (post-ECC). Compared with th...

journal_title：American journal of hematology

authors： Soslau G,Horrow J,Brodsky I

更新日期：1991-10-01 00:00:00

abstract：:Specific anti-human thymus xenoantiserum (ATS) was utilized for characterizing a human thymus antigen (HTA) preferentially expressed on human thymocytes. Binding of ATS with different cell types was studied by immunofluorescence and immunoperoxidase techniques, as well as by radioimmunoprecipitation (RIP) followed by ...

journal_title：American journal of hematology

authors： Fujimoto J,Ishii Y,Koshiba H,Matsuura A,Ogasawara M,Uede T,Kikuchi K

更新日期：1981-01-01 00:00:00

abstract：:Hypereosinophilic syndrome (HES) is a rare disorder that can manifest in various organ systems. We report the case of a 54-year-old woman with a remote history of seizure disorder who presented with early signs of right-sided heart failure. Laboratory studies showed significant eosinophilia (8 x 10(9) l(-1)). Computed...

journal_title：American journal of hematology

authors： Chao BH,Cline-Parhamovich K,Grizzard JD,Smith TJ

更新日期：2007-10-01 00:00:00

abstract：:An association between thrombocytopenia and thyrotoxicosis in a single individual is well documented, and the theories for this event include a common immunologic cause or a thyrotoxic-induced decrease in platelet survival. We report the first description of the coexistence of autoimmune thrombocytopenic purpura (AITP...

journal_title：American journal of hematology

authors： Bizzaro N

更新日期：1992-04-01 00:00:00

abstract：:Severe chronic neutropenia (SCN) is defined as an absolute neutrophil (ANC) of less than 0.5 x 10(9)/L, lasting for months or years. Congenital, cyclic, and idiopathic neutropenia are principal categories of SCN. Since 1994, the Severe Chronic Neutropenia International Registry (SCNIR) has collected data to monitor th...

journal_title：American journal of hematology

authors： Dale DC,Cottle TE,Fier CJ,Bolyard AA,Bonilla MA,Boxer LA,Cham B,Freedman MH,Kannourakis G,Kinsey SE,Davis R,Scarlata D,Schwinzer B,Zeidler C,Welte K

更新日期：2003-02-01 00:00:00

abstract：:Cultured endothelial cells from bovine aorta were exposed to oxidized low density lipoprotein and examined by electron microscopy. The endothelial cells contracted slightly and the intercellular junctions became unclear. Some osmiophilic material increased in the cytoplasm. The oxidized low density lipoprotein appears...

journal_title：American journal of hematology

authors： Zhao B,Zhang Y,Liu B,Nawroth P,Dierichs R

更新日期：1995-07-01 00:00:00

abstract：:Familial Pseudohyperkalemia (FP) is a dominant red cell trait characterized by increased serum [K(+)] in whole blood stored at or below room temperature, without additional hematological abnormalities. Functional gene mapping and sequencing analysis of the candidate genes within the 2q35-q36 critical interval identifi...

journal_title：American journal of hematology

authors： Andolfo I,Alper SL,Delaunay J,Auriemma C,Russo R,Asci R,Esposito MR,Sharma AK,Shmukler BE,Brugnara C,De Franceschi L,Iolascon A

更新日期：2013-01-01 00:00:00

abstract：:Lysosomes (granules) of rabbit PMN leukocytes were extracted with either HCl or H2SO4, and the extracts were chromatographed over Sephadex to separate protein constituents. Some of the low molecular weight cationic proteins homogeneous on SDS PAGE (8% and 12.5% gels) were characterized by electrophoretic mobility in a...

journal_title：American journal of hematology

authors： Herion JC,Bucher JR,Penniall R,Walker RI,Baker M,Roberts HR

更新日期：1979-01-01 00:00:00