Abstract:
:Platelet antibodies are detectable in only about 50% of patients with chronic autoimmune thrombocytopenia (AITP). We determined platelet antibodies against GPIa/IIa, GPIb/IX, GPIIb/IIIa, and GPV and reticulated platelets in three female patients with AITP, before and after immunoadsorption treatment. None of the three patients' sera contained platelet antibodies prior to treatment. Thereafter, anti-GPIIb/IIIa, anti-GPIb/IX (n = 3), and anti-GPV (n = 1) were detectable in the patients' sera. These antibody specificities were also found in the eluates from the immunoadsorption columns. Only one patient had elevated levels of reticulated platelets. Immunoadsorption treatment did not induce a sustained increase of platelet counts in any patient. Immunoadsorption treatment in AITP can induce redistribution of antibodies into the circulation.
journal_name
Am J Hematoljournal_title
American journal of hematologyauthors
Leitner GC,Stiegler G,Horvath M,Hoecker P,Sagaster P,Panzer Sdoi
10.1002/ajh.10312keywords:
subject
Has Abstractpub_date
2003-05-01 00:00:00pages
44-7issue
1eissn
0361-8609issn
1096-8652journal_volume
73pub_type
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