Abstract:
:Collagen is the most important structural protein of the animal body. Its unique triple-helix structure and extremely high level of crystallinity make it exceptionally efficient in generating the second harmonic of incident light, and we show here how this leads to a novel mode of microscopy of immediate practical significance in medicine and biology. In particular, it provides sensitive and high-resolution information on collagen distribution, discriminates between type I and type III collagen, and allows both a greater understanding of and a sensitive test for cirrhosis of the liver. Future research applications could include wound healing and hereditary collagen diseases such as osteogenesis imperfecta.
journal_name
J Struct Bioljournal_title
Journal of structural biologyauthors
Cox G,Kable E,Jones A,Fraser I,Manconi F,Gorrell MDdoi
10.1016/s1047-8477(02)00576-2keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
53-62issue
1eissn
1047-8477issn
1095-8657pii
S1047847702005762journal_volume
141pub_type
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