Abstract:
:Inosine was prepared (15% yield) by treatment of 5-amino-1-beta-D-ribofuranosyl-4-imidazolecarboxamide (AICA-riboside) with chloroform in the presence of sodium methoxide. This ring closure can be reasonably explained by assuming the formation of dichlorocarbene from chloroform and alkali. Carbon tetrachloride or hexachloroethane as a carbene source was more effective for the ring closure of AICA-riboside, giving inosine in 48% and 51% yields respectively.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Okutsu M,Yamazaki Adoi
10.1093/nar/3.1.231keywords:
subject
Has Abstractpub_date
1976-01-01 00:00:00pages
231-5issue
1eissn
0305-1048issn
1362-4962journal_volume
3pub_type
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