当前位置： SCI文献检索 > RESUSCITATION期刊下所有文献 > Glucose, insulin and potassium (GIK) during reperfusion mediates improved myocardial bioenergetics.

Glucose, insulin and potassium (GIK) during reperfusion mediates improved myocardial bioenergetics.

Abstract：

:Previous studies suggest glucose, insulin and potassium (GIK) infusion during ischemia reduces infarct size and improves post-ischemic myocardial function in acute myocardial infarction and following surgical revascularization of the heart. The potential use of GIK when given only during reperfusion after a period of global ischemia, as might occur during cardiac arrest, is unclear. To test the hypothesis that GIK reperfusion improves post-ischemic myocardial bioenergetics and function, we utilized a perfused heart model. Hearts from Sprague-Dawley rats (350-450 g) were perfused at 85 mmHg with oxygenated Krebs-Henseleit bicarbonate containing 5.5 mM glucose and 0.2 mM octanoic acid. Following 20 min of global ischemia, hearts were reperfused for 30 min with original solution (control) or GIK in two different doses (10 or 20 mM glucose each with insulin 10 U/l and K(+) 7 meq/l). Hearts perfused with GIK solutions had significantly higher ATP, creatine phosphate, energy charge, and NADP(+) and lower AMP and inosine levels compared with control after 30 min of reperfusion. Hearts reperfused with GIK had significantly higher developed pressure and higher dP/dt than control reperfused hearts. Reperfusion with GIK improved post-ischemic recovery of both contractile function and the myocardial bioenergetic state. GIK may be a viable adjunctive reperfusion therapy following the global ischemia of cardiac arrest to improve post-resuscitation cardiac dysfunction.

journal_name

Resuscitation

journal_title

Resuscitation

authors

Angelos MG,Murray HN,Gorsline RT,Klawitter PF

doi

10.1016/s0300-9572(02)00215-0

keywords:

subject

Has Abstract

pub_date

2002-12-01 00:00:00

pages

329-36

issue

3

eissn

0300-9572

issn

1873-1570

pii

S0300957202002150

journal_volume

55

pub_type

杂志文章

相关文献

RESUSCITATION文献大全
  • Clinical emergencies and outcomes in patients admitted to a surgical versus medical service.

    abstract：BACKGROUND:The merit of rapid response systems (RRSs) remains controversial. A tailored approach to specific groups may increase the efficacy of these teams. The purpose of this study was to compare differences in triggers for RRS activation, interventions, and outcomes in patients on medical and surgical services. ME...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/j.resuscitation.2010.12.005

    authors： Sarani B,Palilonis E,Sonnad S,Bergey M,Sims C,Pascual JL,Schweickert W

    更新日期：2011-04-01 00:00:00

  • Prospective, randomized trial of the effectiveness and retention of 30-min layperson training for cardiopulmonary resuscitation and automated external defibrillators: The American Airlines Study.

    abstract：OBJECTIVE:A head-to-head trial was conducted to compare laypersons' long-term retention of life-saving psychomotor and cognitive skills learned in the traditional multi-hour training format for basic cardiopulmonary resuscitation and automated external defibrillator use to those learned in an abbreviated (30 min) cours...

    journal_title：Resuscitation

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.resuscitation.2006.12.017

    authors： Roppolo LP,Pepe PE,Campbell L,Ohman K,Kulkarni H,Miller R,Idris A,Bean L,Bettes TN,Idris AH

    更新日期：2007-08-01 00:00:00

  • Deeper chest compression - more complications for cardiac arrest patients?

    abstract：AIM OF THE STUDY:Sternal and rib fractures are frequent complications caused by chest compressions during cardiopulmonary resuscitation (CPR). This study aimed to investigate the potential association of CPR-related thoracic and abdominal injuries and compression depth measured with an accelerometer. METHODS:We analys...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/j.resuscitation.2013.02.015

    authors： Hellevuo H,Sainio M,Nevalainen R,Huhtala H,Olkkola KT,Tenhunen J,Hoppu S

    更新日期：2013-06-01 00:00:00

  • Emergency cardio-pulmonary bypass in cardiac arrest: seventeen years of experience.

    abstract：AIM:Emergency cardiopulmonary bypass (E-CPB) is an advanced and rarely used procedure for patients in cardiac arrest that do not regain restoration of spontaneous circulation with standard resuscitation methods. The feasibility, safety and outcome of the intervention with E-CPB in cardiac arrest situations at our depar...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/j.resuscitation.2012.05.029

    authors： Wallmüller C,Sterz F,Testori C,Schober A,Stratil P,Hörburger D,Stöckl M,Weiser C,Kricanac D,Zimpfer D,Deckert Z,Holzer M

    更新日期：2013-03-01 00:00:00

  • Measuring cardiopulmonary resuscitation performance: a comparison of the Heartsaver checklist to manikin strip.

    abstract：:Both checklists and recording manikin strips (strips) are used for evaluation of cardiopulmonary resuscitation (CPR) performance. To examine their relationship, we simultaneously evaluated single rescuer CPR of 255 subjects using both checklists and strips. For Group 1 (N = 192; general public tested in Heartsaver cou...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/0300-9572(90)90036-e

    authors： Mancini ME,Kaye W

    更新日期：1990-04-01 00:00:00

  • Benefit of immediate coronary angiography after out-of-hospital cardiac arrest in France: A nationwide propensity score analysis from the RéAC Registry.

    abstract：BACKGROUND:The survival rate of out-of-hospital cardiac arrest (OHCA) remains extremely low, generally under 10%. Post-resuscitation care, and particularly early coronary reperfusion, may improve this outcome. The main objective of the present study was to determine whether patients with immediate coronary angiography ...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/j.resuscitation.2018.03.003

    authors： Jaeger D,Dumas F,Escutnaire J,Sadoune S,Lauvray A,Elkhoury C,Bassand A,Girerd N,Gueugniaud PY,Tazarourte K,Hubert H,Cariou A,Chouihed T,Reac Group.

    更新日期：2018-05-01 00:00:00

  • Ventilation performance of a mixed group of operators using a new rescue breathing device-the glossopalatinal tube.

    abstract：INTRODUCTION:We studied how effectively a mixed group of helpers could ventilate a manikin with a new rescue breathing device after a short period of instruction. The device consists of a mouthcap, a "glossopalatinal tube" (GPT) reaching between tongue and palate and a connector for a bag, ventilator or the rescuers mo...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/s0300-9572(03)00205-3

    authors： Reissmann H,Birkholz S,Ohnesorge H,Jensen K,Eckert S,Nierhaus A,Schulte am Esch J

    更新日期：2003-11-01 00:00:00

  • Delta opioid receptor agonist BW373U86 attenuates post-resuscitation brain injury in a rat model of asphyxial cardiac arrest.

    abstract：OBJECTIVE:The aim of this study was to investigate whether the DOR agonist BW373U86 conferred neuroprotection following ACA when given after resuscitation and to determine the long-term effects of chronic BW373U86 treatment on ACA-elicited brain injury. METHODS:Animals were divided into acute and chronic treatment gro...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/j.resuscitation.2013.10.022

    authors： Yang L,Zhao X,Sun M,Sun X,Yao L,Yu D,Ding Q,Gao C,Chai W

    更新日期：2014-02-01 00:00:00

  • Prognostic role of EEG identical bursts in patients after cardiac arrest: Multimodal correlation.

    abstract：AIMS:EEG burst-suppression (BS) heralds poor outcome after cardiac arrest (CA). Within this pattern, identical bursts (IB) have been suggested to be absolutely specific, in isolation. We assessed IB prevalence and their added predictive value for poor outcome in a multimodal prognostic approach. METHODS:We retrospecti...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/j.resuscitation.2020.01.017

    authors： Barbella G,Novy J,Marques-Vidal P,Oddo M,Rossetti AO

    更新日期：2020-03-01 00:00:00

  • The effect of a specialized content knowledge workshop on teaching and learning Basic Life Support in elementary school: A cluster randomized controlled trial.

    abstract：BACKGROUND:Research investigating the effect of specialised content knowledge (SCK) on teaching and learning Basic Life Support (BLS) is lacking. PURPOSE:To investigate the effect of a specialised content knowledge workshop on teaching behaviour, lesson context and student learning of BLS. Specialised content knowledg...

    journal_title：Resuscitation

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.resuscitation.2016.11.023

    authors： Iserbyt P,Theys L,Ward P,Charlier N

    更新日期：2017-03-01 00:00:00

  • Team performance in the emergency room: assessment of inter-disciplinary attitudes.

    abstract：:In-hospital emergency medicine in central Europe relies on inter-disciplinary co-operation. To improve team performance in the emergency room (ER), a questionnaire for assessment of attitudes and judgements in resuscitation procedures was developed. A total of 43 items were evaluated according to a five-point Likert s...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/s0300-9572(00)00304-x

    authors： Ummenhofer W,Amsler F,Sutter PM,Martina B,Martin J,Scheidegger D

    更新日期：2001-04-01 00:00:00

  • A scoring system for the assessment of basic life support ability.

    abstract：INTRODUCTION:There are no current validated scoring systems for the assessment of adult single rescuer basic life support (BLS) ability. A system was proposed and prospectively validated. METHODS:The system was tested firstly on 12 skilled BLS providers (all instructors). It was then further evaluated on 75 undergradu...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/s0300-9572(99)00135-5

    authors： Graham CA,Lewis NF

    更新日期：2000-01-01 00:00:00

  • Intracerebroventricular application of granulocyte colony-stimulating factor after cardiac arrest does not promote beneficial effects on cerebral recovery after cardiac arrest in rats.

    abstract：SUBJECT:Recent data demonstrated potent neuroprotective effects of growth hormones such as granulocyte colony-stimulating factor (G-CSF) after focal cerebral ischaemia. In order to assess possible effects of intracerebroventricular application of G-CSF on cerebral recovery after cardiac arrest (CA) in rats, neurologica...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/j.resuscitation.2009.01.003

    authors： Popp E,Rabsahl T,Schneider A,Russ N,Spöhr F,Vogel P,Böttiger BW,Teschendorf P

    更新日期：2009-04-01 00:00:00

  • Influence of pre-course assessment using an emotionally activating stimulus with feedback: a pilot study in teaching Basic Life Support.

    abstract：BACKGROUND:Cardiopulmonary resuscitation (CPR) mastery continues to challenge medical professionals. The purpose of this study was to determine if an emotional stimulus in combination with peer or expert feedback during pre-course assessment effects future performance in a single rescuer simulated cardiac arrest. METH...

    journal_title：Resuscitation

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.resuscitation.2011.08.024

    authors： Beckers SK,Biermann H,Sopka S,Skorning M,Brokmann JC,Heussen N,Rossaint R,Younker J

    更新日期：2012-02-01 00:00:00

  • Ventricular fibrillation waveform characteristics of the surface ECG: Impact of the left ventricular diameter and mass.

    abstract：BACKGROUND:Despite a promising association between VF waveform characteristics and prognosis after resuscitation, studies with VF-guided treatment have so far not improved outcomes. While driven by the idea that the VF waveform reflects arrest duration, increasing evidence suggests that pre-existent disease-related cha...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/j.resuscitation.2017.03.029

    authors： Bonnes JL,Thannhauser J,Nas J,Westra SW,Jansen RMG,Meinsma G,de Boer MJ,Smeets JLRM,Keuper W,Brouwer MA

    更新日期：2017-06-01 00:00:00

  • Over-transfusion ascites.

    abstract：:A 12-year-old girl was injured in a traffic accident and suffered fractures of all the long bones of both legs. During the operation she received 10 l of lactated Ringer's solution, 3 l of 0.9% NaCl, and 2 l of 5% glucose, until blood was available, because of difficulty in its cross-matching. Her hemoglobin dropped t...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/0300-9572(91)90054-3

    authors： Eldor J,Olsha O,Farkas A

    更新日期：1991-04-01 00:00:00

  • Optimal training frequency for acquisition and retention of high-quality CPR skills: A randomized trial.

    abstract：AIM:Spaced training programs employ short, frequent CPR training sessions to improve provider skills. The optimum training frequency for CPR skill acquisition and retention has not been determined. We aimed to determine the training interval associated with the highest quality CPR performance at one year. METHODS:Part...

    journal_title：Resuscitation

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.resuscitation.2018.10.033

    authors： Anderson R,Sebaldt A,Lin Y,Cheng A

    更新日期：2019-02-01 00:00:00

  • Helium ventilation for treatment of post-cardiac arrest syndrome: A safety and feasibility study.

    abstract：AIM:Besides supportive care, the only recommended treatment for comatose patients after cardiac arrest is target temperature management. Helium reduces ischaemic injury in animal models, and might ameliorate neurological injury in patients after cardiac arrest. As no studies exist on the use of helium in patients after...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/j.resuscitation.2016.07.004

    authors： Brevoord D,Beurskens CJ,van den Bergh WM,Lagrand WK,Juffermans NP,Binnekade JM,Preckel B,Horn J

    更新日期：2016-10-01 00:00:00

  • The effect on quality of chest compressions and exhaustion of a compression--ventilation ratio of 30:2 versus 15:2 during cardiopulmonary resuscitation--a randomised trial.

    abstract：BACKGROUND:Recent cardio pulmonary resuscitation (CPR) guidelines changed the compression:ventilation ratio in 30:2. OBJECTIVE:To compare the quality of chest compressions and exhaustion using the ratio 30:2 versus 15:2. METHODS:A prospective, randomised crossover design was used. Subjects were recruited from the H.-...

    journal_title：Resuscitation

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.resuscitation.2006.12.004

    authors： Deschilder K,De Vos R,Stockman W

    更新日期：2007-07-01 00:00:00

  • Microcirculatory perfusion and vascular reactivity are altered in post cardiac arrest patients, irrespective of target temperature management to 33 °C vs 36 °C.

    abstract：AIM:In previous reports both microcirculatory alterations and impaired vascular reactivity have been described in post cardiac arrest patients treated with mild therapeutic hypothermia. As of now it is unknown whether these alterations are related to the temperature management or to the cardiac arrest itself. Aim of th...

    journal_title：Resuscitation

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.resuscitation.2014.09.025

    authors： Koopmans M,Kuiper MA,Endeman H,Veenstra G,Vellinga NA,de Vos R,Boerma EC

    更新日期：2015-01-01 00:00:00

  • Correlation between acid-base status, concentrations of lactate and of pyruvate in blood and cerebrospinal fluid in patients treated in an intensive care unit.

    abstract：:Results of examinations of 41 patients treated in an intensive care unit are reported. The patients were divided into three groups and examined on the first and twelfth days of treatment. In the first group were 15 patients who had received circulatory resuscitation, the second group was 13 patients with lesions of th...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/0300-9572(75)90062-3

    authors： Wołowicka L,Drobnik L,Tomaszkiewicz T

    更新日期：1975-01-01 00:00:00

  • Continuous cardiac index monitoring: A prospective observational study of agreement between a pulmonary artery catheter and a calibrated minimally invasive technique.

    abstract：INTRODUCTION:Continuous cardiac index (CCI) monitoring can provide information to assist in hemodynamic support. However, pulmonary artery catheters (PAC) pose logistic challenges in acute care settings. We hypothesized that CCI measured with a calibrated minimally invasive technique (LiDCO/PulseCO, UK) would have good...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/j.resuscitation.2009.04.015

    authors： McCoy JV,Hollenberg SM,Dellinger RP,Arnold RC,Ruoss L,Lotano V,Peters P,Parrillo JE,Trzeciak S

    更新日期：2009-08-01 00:00:00

  • A moderate dose of propofol and rapidly induced mild hypothermia with extracorporeal lung and heart assist (ECLHA) improve the neurological outcome after prolonged cardiac arrest in dogs.

    abstract：BACKGROUND AND PURPOSE:Propofol has been shown to protect against neuronal damage induced by brain ischaemia in small animal models. We reported previously that mild hypothermia (33 degrees C) in combination with extracorporeal lung and heart assist (ECLHA) improved the neurological outcome in dogs with cardiac arrest ...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/j.resuscitation.2005.12.011

    authors： Ichinose K,Okamoto T,Tanimoto H,Taguchi H,Tashiro M,Sugita M,Takeya M,Terasaki H

    更新日期：2006-08-01 00:00:00

  • Thiopental combination treatments for cerebral resuscitation after prolonged cardiac arrest in dogs. Exploratory outcome study.

    abstract：:We postulate that mitigating the multifactorial pathogenesis of postischemic encephalopathy requires multifaceted treatments. In preparation for expensive definitive studies, we are reporting here the results of small exploratory series, compared with historic controls with the same model. We hypothesized that the bra...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/s0300-9572(00)00173-8

    authors： Ebmeyer U,Safar P,Radovsky A,Xiao F,Capone A,Tanigawa K,Stezoski SW

    更新日期：2000-07-01 00:00:00

  • Adult in-hospital cardiac arrest in Denmark.

    abstract：AIM:The aim of this study was to describe patient characteristics, event characteristics, and outcomes for patients with in-hospital cardiac arrest in Denmark. METHODS:Data was obtained from DANARREST. DANARREST is a nationwide registry that covers all in-hospital cardiac arrests in Denmark with a clinical indication ...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/j.resuscitation.2019.04.046

    authors： Andersen LW,Holmberg MJ,Løfgren B,Kirkegaard H,Granfeldt A

    更新日期：2019-07-01 00:00:00

  • Quantitative pupillometry and transcranial Doppler measurements in patients treated with hypothermia after cardiac arrest.

    abstract：BACKGROUND:Predicting outcome after cardiac arrest (CA) is particularly difficult when therapeutic hypothermia (TH) is used. We investigated the performance of quantitative pupillometry and transcranial Doppler (TCD) in this context. METHODS:This prospective observational study included 82 post-CA patients. Quantitati...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/j.resuscitation.2016.02.026

    authors： Heimburger D,Durand M,Gaide-Chevronnay L,Dessertaine G,Moury PH,Bouzat P,Albaladejo P,Payen JF

    更新日期：2016-06-01 00:00:00

  • Evaluation of a defibrillator-basic cardiopulmonary resuscitation programme for non medical personnel.

    abstract：:To improve the outcome for out-of-hospital patients with ventricular fibrillation/pulseless ventricular tachycardia (VF/VT), the use of automated external defibrillators (AEDs) by first responders including non-medical personnel with a duty to respond to an emergency is recommended. A special CPR-AED course has been d...

    journal_title：Resuscitation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0300-9572(02)00351-9

    authors： Wik L,Dorph E,Auestad B,Andreas Steen P

    更新日期：2003-02-01 00:00:00

  • Sports activity and paediatric out-of-hospital cardiac arrest at schools in Japan.

    abstract：BACKGROUND:Sudden cardiac death during exercise or sports is an important problem among young athletes and non-athletes. An understanding of the epidemiological features of sports-related out-of-hospital cardiac arrest (OHCA) among children is crucial for planning approaches for prevention and better outcomes of paedia...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/j.resuscitation.2019.03.041

    authors： Sado J,Kiyohara K,Kitamura T,Matsui S,Ayusawa M,Nitta M,Iwami T,Nakata K,Sobue T,Kitamura Y,SPIRITS investigators.

    更新日期：2019-06-01 00:00:00

  • Resuscitation of out-of-hospital cardiac arrest by Asian primary health-care physicians.

    abstract：AIM:To assess the experience, knowledge and attitudes of local primary health-care doctors towards resuscitation in out-of-hospital cardiac arrest. METHODS:We conducted a survey of general practitioners (GPs) working in both private and public sectors. The survey consisted of 29 questions and was self-administered. R...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/j.resuscitation.2004.11.021

    authors： Ong ME,Chan YH,Ang HY,Lim SH,Tan KL

    更新日期：2005-05-01 00:00:00

  • Use of double sequential external defibrillation for refractory ventricular fibrillation during out-of-hospital cardiac arrest.

    abstract：INTRODUCTION:Survival from out of hospital cardiac arrest (OHCA) is highest in victims with shockable rhythms when early CPR and rapid defibrillation are provided. However, a subset of individuals present with ventricular fibrillation (VF) that does not respond to defibrillation (refractory VF). One intervention that m...

    journal_title：Resuscitation

    pub_type： 杂志文章

    doi：10.1016/j.resuscitation.2016.08.002

    authors： Cortez E,Krebs W,Davis J,Keseg DP,Panchal AR

    更新日期：2016-11-01 00:00:00