Response of donor and recipient cells after transplantation of cells to the ligament and tendon.

Abstract:

:The mechanical properties of healing ligaments and tendons are not comparable to those of normal tissue. To improve the quality of the ligament healing, therapeutic strategies include gene transfer or placement of mesenchymal stem cells at the healing site. Studies show that marker genes, growth factors, and antisense oligonucleotides can be delivered to both normal and healing ligaments and tendons by gene transfer. Cells with and without genetic modification have been successfully transplanted to ligaments and tendons and remain viable. Tendon healing can be improved using collagen gel implants seeded with autologous mesenchymal stem cells. Even though these early results are encouraging, more work is required regarding the response of the recipient site to donor cells or vectors.

journal_name

Microsc Res Tech

authors

Hildebrand KA,Jia F,Woo SL

doi

10.1002/jemt.10114

keywords:

subject

Has Abstract

pub_date

2002-07-01 00:00:00

pages

34-8

issue

1

eissn

1059-910X

issn

1097-0029

journal_volume

58

pub_type

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