A case of primary bilateral adrenal lymphoma (PAL) with central nervous system (CNS) involvement.

Abstract:

:Primary adrenal lymphoma (PAL) is a very rare disease and usually does not have disease elsewhere, and if present, it is frequently extranodal. Several cases of PALs, with central nervous system (CNS) involvement, gastrointestinal tract or other endocrine organs involvement, have been reported in Western literature. We experienced a case of PAL with CNS involvement, which was previously unreported in Korea. The patient, a 61 year-old male, was admitted with left abdominal pain. After imaging study and needle aspiration biopsy (NAB), a bilateral primary adrenal lymphoma (large B-cell type), with bilateral hemorrhage, was confirmed. Combination chemotherapy, with CEOP regimen, was used. A follow-up abdomino- pelvic CT scan, after the second CEOP chemotherapy, showed the previous adrenal masses had nearly disappeared. However, about 2 months after diagnosis (day 52), he showed recent memory loss, obtundation, disorientation and drowsy mental status. The brain MRI revealed multifocal scattered lesions with increased signal intensity. The result of a brain biopsy was diffuse large B-cell lymphoma. After 5(1/2) cycles of chemotherapy, with CEOP regimen, and whole brain radiotherapy, he is still surviving 6 months later, and has become alert with nearly normalized cognitive function.

journal_name

Yonsei Med J

journal_title

Yonsei medical journal

authors

Hahn JS,Choi HS,Suh CO,Lee WJ

doi

10.3349/ymj.2002.43.3.385

keywords:

subject

Has Abstract

pub_date

2002-06-01 00:00:00

pages

385-90

issue

3

eissn

0513-5796

issn

1976-2437

pii

200206385

journal_volume

43

pub_type

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