Abstract:
:We previously reported that insulin resistance in skeletal muscle of obese individuals was associated with decreases in insulin signal transduction and tyrosine kinase activity of the insulin receptor. Herein is reviewed the recently published data supporting the hypothesis that protein kinase C (PKC) phosphorylates the insulin receptor on serine/threonine residues to decrease tyrosine kinase activity and cause insulin resistance. Treatment of insulin receptors from obese subjects with alkaline phosphatase restored tyrosine kinase activity, suggesting that the reduced activity was a result of hyperphosphorylation of the receptor. Incubating human muscle fiber strips with PKC inhibitors restored insulin action in muscle of obese patients, while activating PKC with a phorbol ester caused insulin resistance in muscle from lean control patients. The beta isoform of PKC was elevated in muscle of obese, insulin-resistant patients. These data are consistent with the hypothesis that elevated PKC activity may cause insulin resistance by phosphorylating the insulin receptor to decrease tyrosine kinase activity.
journal_name
Int J Sport Nutr Exerc Metabauthors
Dohm GLdoi
10.1123/ijsnem.11.s1.s64keywords:
subject
Has Abstractpub_date
2001-12-01 00:00:00pages
S64-70eissn
1526-484Xissn
1543-2742journal_volume
11 Supplpub_type
杂志文章,评审abstract::Aspiring female physique athletes are often encouraged to ingest relatively high levels of dietary protein in conjunction with their resistance training programs. However, there is little to no research investigating higher versus lower protein intakes in this population. This study examined the influence of a high ve...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章,随机对照试验
doi:10.1123/ijsnem.2017-0389
更新日期:2018-11-01 00:00:00
abstract::The purpose of this study was to examine the effect of high-intensity physical activity during training on the biochemical status of thiamin and riboflavin in athletes. Thiamin and riboflavin concentrations in whole blood of a group of 19 athletes (6 men and 13 women) were measured during a low-intensity preparatory p...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章
doi:10.1123/ijsnem.21.3.195
更新日期:2011-06-01 00:00:00
abstract::Athletes employ various dietary strategies in attempts to attenuate exercise-induced gastrointestinal (GI) symptoms to ensure optimal performance. This case-study outlines one of these GI-targeted approaches via the implementation of a short-term low FODMAP (Fermentable Oligosaccharides, Disaccharides, Monosaccharides...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章
doi:10.1123/ijsnem.2015-0293
更新日期:2016-10-01 00:00:00
abstract::Heavy exercise is associated with an increased risk of upper respiratory tract infections. Strenuous exercise also causes gastrointestinal (GI) symptoms. In previous studies probiotics have reduced respiratory tract infections and GI symptoms in general populations including children, adults, and the elderly. These qu...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章,随机对照试验
doi:10.1123/ijsnem.17.4.352
更新日期:2007-08-01 00:00:00
abstract::Postexercise fat oxidation may be important for exercise prescription aimed at optimizing fat loss. The authors examined the effects of exercise intensity, duration, and modality on postexercise oxygen consumption (VO2) and substrate selection/ respiratory-exchange ratio (RER) in healthy individuals. Three experiments...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章,随机对照试验
doi:10.1123/ijsnem.19.6.607
更新日期:2009-12-01 00:00:00
abstract::The purpose of this study was to assess the influence of rehydration with a caffeinated beverage during nonexercise periods on hydration status throughout consecutive practices in the heat. Ten (7 women, 3 men) partially heat- acclimated athletes (age 24 +/-1y, body fat 19.2 +/- 2 %, weight 68.4 +/- 4.0 kg, height 170...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1123/ijsnem.14.4.419
更新日期:2004-08-01 00:00:00
abstract::This study examined the effect of amino acids in a carbohydrate beverage on cycling performance. Twelve male athletes (28.5 +/- 2.1 yr) cycled at 75% VO2peak for 90 min followed by a ride to exhaustion at 85% VO2peak, before (T1) and on 2 consecutive days (T2 and T3) after 2 weeks of supplementation with 3.6% carbohyd...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章,随机对照试验
doi:10.1123/ijsnem.18.5.473
更新日期:2008-10-01 00:00:00
abstract:PURPOSE:The purpose of this study was to investigate the effect of acute and 4-week Rhodiola rosea intake on physical capacity, muscle strength, speed of limb movement, reaction time, and attention. METHODS: PHASE I:A double blind placebo-controlled randomized study (n= 24) was performed, consisting of 2 sessions (2 ...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1123/ijsnem.14.3.298
更新日期:2004-06-01 00:00:00
abstract::Food-based diet indices provide a practical, rapid, and inexpensive way of evaluating dietary intake. Rather than nutrients, diet indices assess the intake of whole foods and dietary patterns, and compare these with nutrition guidelines. An athlete-specific diet index would offer an efficient and practical way to asse...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章
doi:10.1123/ijsnem.2019-0098
更新日期:2019-10-17 00:00:00
abstract::Although beetroot juice, as a nitrate carrier, is a popular ergogenic supplement among athletes, nitrate is consumed through the regular diet as well. We aimed to assess the habitual dietary nitrate intake and identify the main contributing food sources in a large group of highly trained athletes. Dutch highly trained...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章
doi:10.1123/ijsnem.2016-0239
更新日期:2017-04-01 00:00:00
abstract::Whenever athletes willfully or accidentally ingest performance-enhancing drugs or other banned substances (such as drugs of abuse), markers of those drugs can be detected in biological samples (e.g., biofluids: urine, saliva, blood); in the case of some drugs, that evidence can be apparent for many weeks following the...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 历史文章,杂志文章,评审
doi:10.1123/ijsnem.2014-0185
更新日期:2015-08-01 00:00:00
abstract::Endurance athletes commonly ingest caffeine as a means to enhance training intensity and competitive performance. A widely-used source of caffeine is coffee, however conflicting evidence exists regarding the efficacy of coffee in improving endurance performance. In this context, the aims of this evidence-based review ...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章,评审
doi:10.1123/ijsnem.2015-0147
更新日期:2016-06-01 00:00:00
abstract::Special operation forces participating in mountain warfare/cold weather (MWCW) training have higher energy demands, but adequate fueling is difficult to achieve. The purpose of the study was to determine energy expenditure relative to energy intake and examine fueling patterns during 3 days of MWCW training in Naval S...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章
doi:10.1123/ijsnem.2018-0041
更新日期:2019-05-01 00:00:00
abstract::This study characterized body composition profiles of elite American heptathletes and cross-validated skinfold (SKF) and bioelectrical impedance analysis (BIA) field method equations for estimation of percent body fat (%Fat) using dual energy x-ray absorptiometry (DXA) as the criterion. Weight, height, fat mass (FM), ...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章
doi:10.1123/ijsnem.11.2.162
更新日期:2001-06-01 00:00:00
abstract::The purpose of this study was to examine the prevalence of disordered eating (DE), menstrual dysfunction (MD), and low bone mineral density (BMD) among US collegiate athletes (n = 112) representing 7 different sports (diving, swimming, x-country, track, tennis, field hockey, and softball) and determine differences in ...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章
doi:10.1123/ijsnem.16.1.1
更新日期:2006-02-01 00:00:00
abstract::The effects of acute ingestion of caffeine on short-duration high-intensity performance are equivocal, while studies of novel modes of delivery and the efficacy of low doses of caffeine are warranted. The aims of the present study were to investigate the effect of acute ingestion of caffeinated chewing gum on repeated...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章,随机对照试验
doi:10.1123/ijsnem.2017-0217
更新日期:2018-05-01 00:00:00
abstract::The aim of the present study was to investigate the effect of vitamin C with or without carbohydrate consumed acutely in beverages before and during prolonged cycling on immunoendocrine responses. In a single blind, randomized manner six healthy, moderately trained males exercised for 2.5 h at 60% VO(2max)and consumed...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章,随机对照试验
doi:10.1123/ijsnem.15.5.465
更新日期:2005-10-01 00:00:00
abstract::The authors compared the effectiveness of daily (DAY) versus alternate day (ALT) oral iron supplementation in athletes with suboptimal iron. Endurance-trained runners (nine males and 22 females), with serum ferritin (sFer) concentrations <50 μg/L, supplemented with oral iron either DAY or ALT for 8 weeks. Serum ferrit...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章
doi:10.1123/ijsnem.2019-0310
更新日期:2020-03-27 00:00:00
abstract::Rugby union athletes have divergent body composition based on the demands of their on-field playing position and ethnicity. With an established association between physique traits and positional requirements, body composition assessment is routinely undertaken. Surface anthropometry and dual-energy X-ray absorptiometr...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章
doi:10.1123/ijsnem.2018-0019
更新日期:2018-09-26 00:00:00
abstract::Research suggests that ingesting protein after resistance exercise (RE) increases muscle protein synthesis and results in greater muscle gains. The effect on energy expenditure and substrate utilization, however, is unclear. This study evaluated the effect of RE and postexercise protein on recovery energy expenditure ...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章,随机对照试验
doi:10.1123/ijsnem.17.6.544
更新日期:2007-12-01 00:00:00
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journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章
doi:10.1123/ijsnem.2017-0313
更新日期:2018-07-01 00:00:00
abstract::Tonic vagal modulation of cardiac period (R-R interval) decreases with advancing age, but is greater in middle-aged and older adults who habitually perform aerobic exercise compared with their sedentary peers. Cardiovagal baroreflex sensitivity also declines markedly with age in sedentary adults but only 50% as much i...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章,评审
doi:10.1123/ijsnem.11.s1.s189
更新日期:2001-12-01 00:00:00
abstract::This study examined whether acute taurine (T) ingestion before prolonged cycling would improve time-trial (TT) performance and alter whole-body fuel utilization compared with a control (CON) trial and a placebo (PL) trial in which participants were told they received taurine but did not. Eleven endurance-trained male ...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章,随机对照试验
doi:10.1123/ijsnem.20.4.322
更新日期:2010-08-01 00:00:00
abstract::To defend against hydrogen cation accumulation and muscle fatigue during exercise, sodium bicarbonate (NaHCO3) ingestion is commonplace. The individualized dose-response relationship between NaHCO3 ingestion and blood biochemistry is unclear. The present study investigated the bicarbonate, pH, base excess and sodium r...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章,随机对照试验
doi:10.1123/ijsnem.2015-0286
更新日期:2016-10-01 00:00:00
abstract::The polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) affect vascular relaxation and involve factors (e.g., nitric oxide) that contribute to exercise-induced increases in skeletal-muscle blood flow (Q). The authors investigated whether DHA and EPA supplementation augments skeletal-...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章
doi:10.1123/ijsnem.20.6.475
更新日期:2010-12-01 00:00:00
abstract::The purpose of the current study was to evaluate changes in body composition, metabolic rate, and hormones during postcompetition recovery. Data were collected from natural physique athletes (7 male/8 female) within one week before (T1) competition, within one week after (T2), and 4-6 weeks after (T3) competition. Mea...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章
doi:10.1123/ijsnem.2017-0038
更新日期:2017-10-01 00:00:00
abstract::The purpose of this study was to compare biochemical and hormonal responses between mixed martial arts (MMA) competitors with minimal prefight weight loss and those undergoing rapid weight loss (RWL). Blood samples were taken from 17 MMA athletes (Mean± SD; age: 27.4 ±5.3yr; body mass: 76.2 ± 12.4kg; height: 1.71 ± 0....
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章
doi:10.1123/ijsnem.2014-0267
更新日期:2015-10-01 00:00:00
abstract::Athletes competing in individual sports such as judo are categorized by weight. Before competitions, weight cutting is common. This cross-sectional study was designed to characterize and determine the prevalence of rapid weight loss (RWL) among adolescent judo competitors. Male athletes aged 12- to 17-years old (N = 1...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章
doi:10.1123/ijsnem.2015-0196
更新日期:2016-06-01 00:00:00
abstract::Inflammatory markers such as C-reactive protein (CRP), fibrinogen, and white-blood-cell (WBC) count are strongly associated with cardiovascular disease. The authors' purpose was to compare the inflammatory response to a single aerobic-exercise session between individuals of high and moderate fitness. Ten apparently he...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章
doi:10.1123/ijsnem.17.2.152
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:To compare the effects of a 3-week supplementation between two different mixtures of antioxidants and placebo on aerobic exercise performance in acute normobaric hypoxia. SUBJECTS/METHODS:Seventeen subjects were randomly assigned in a double-blind fashion to receive a broad-based antioxidants sup...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章,随机对照试验
doi:10.1123/ijsnem.2013-0118
更新日期:2014-04-01 00:00:00