Mediation of elicitin activity on tobacco is assumed by elicitin-sterol complexes.

abstract：:Many of the actions of the neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. We delineated this endocytic pathway in transfected cells by confocal microscopy using cyanine 3-SP and NK1-R antibo...

journal_title：Molecular biology of the cell

authors： Grady EF,Garland AM,Gamp PD,Lovett M,Payan DG,Bunnett NW

更新日期：1995-05-01 00:00:00

abstract：:Recent evidence has shown that members of the Jak kinase family are activated after IL-6 binds to its receptor complex, leading to a tyrosine phosphorylation of gp130, the IL-6 signal-transducing subunit. The different members of the IL-6 cytokine subfamily induce distinct patterns of Jak-Tyk phosphorylation in differ...

journal_title：Molecular biology of the cell

authors： Wang Y,Fuller GM

更新日期：1994-07-01 00:00:00

abstract：:Endomitosis is a special type of mitosis in which only cytokinesis-the final step of the cell division cycle-is defective, resulting in polyploid cells. Although endomitosis is biologically important, its regulatory aspects remain elusive. Psychosine, a lysogalactosylceramide, prevents proper cytokinesis when suppleme...

journal_title：Molecular biology of the cell

authors： Watanabe H,Okahara K,Naito-Matsui Y,Abe M,Go S,Inokuchi J,Okazaki T,Kobayashi T,Kozutsumi Y,Oka S,Takematsu H

更新日期：2016-07-01 00:00:00

abstract：:Exposure of neutrophils to chemoattractant induces cell polarization and migration. These behaviors require the asymmetric activation of distinct signaling pathways and cytoskeletal elements in the protruding pseudopod at the front of cells and the retracting uropod at the rear. An important outstanding question is, h...

journal_title：Molecular biology of the cell

authors： Bodin S,Welch MD

更新日期：2005-12-01 00:00:00

abstract：:Cells have evolved an autoregulatory mechanism to dampen variations in the concentration of tubulin monomer that is available to polymerize into microtubules (MTs), a process that is known as tubulin autoregulation. However, thermodynamic analysis of MT polymerization predicts that the concentration of free tubulin mo...

journal_title：Molecular biology of the cell

authors： Mooney DJ,Hansen LK,Langer R,Vacanti JP,Ingber DE

更新日期：1994-12-01 00:00:00

abstract：:Many integrin receptors localize to focal contact sites upon binding their ligand. However, unoccupied integrin receptors do not localize to focal contact sites. Because the integrin beta 1 cytoplasmic domain appears to have a focal contact localization signal, there must be a mechanism by which this domain is kept in...

journal_title：Molecular biology of the cell

authors： Briesewitz R,Kern A,Marcantonio EE

更新日期：1993-06-01 00:00:00

abstract：:We have isolated mutants in the fission yeast Schizosaccharomyces pombe that are defective in protein glycosylation. A collection of osmotically sensitive mutants was prepared and screened for glycosylation defects using lectin staining as an assay. Mutants singly defective in four glycoprotein synthesis genes (gps1-4...

journal_title：Molecular biology of the cell

authors： Huang KM,Snider MD

更新日期：1995-05-01 00:00:00

abstract：:The Cdc42 guanosine triphosphatase (GTPase) plays a central role in polarity development in species ranging from yeast to humans. In budding yeast, a specific growth site is selected in the G1 phase. Rsr1, a Ras GTPase, interacts with Cdc42 and its associated proteins to promote polarized growth at the proper bud site...

journal_title：Molecular biology of the cell

authors： Miller KE,Lo WC,Chou CS,Park HO

更新日期：2019-09-15 00:00:00

abstract：:Protein phosphatase 1 (PP1) is a ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. When transiently expressed as fluorescent protein (FP) fusions, the three PP1 isoforms, alpha, beta/delta, and gamma1, are active phosphatases with distinct localization patterns. W...

journal_title：Molecular biology of the cell

authors： Trinkle-Mulcahy L,Andrews PD,Wickramasinghe S,Sleeman J,Prescott A,Lam YW,Lyon C,Swedlow JR,Lamond AI

更新日期：2003-01-01 00:00:00

abstract：:Shroom (Shrm) proteins are essential regulators of cell shape and tissue morpho-logy during animal development that function by interacting directly with the coiled-coil region of Rho kinase (Rock). The Shrm-Rock interaction is sufficient to direct Rock subcellular localization and the subsequent assembly of contracti...

journal_title：Molecular biology of the cell

authors： Mohan S,Rizaldy R,Das D,Bauer RJ,Heroux A,Trakselis MA,Hildebrand JD,VanDemark AP

更新日期：2012-06-01 00:00:00

abstract：:The dynein light intermediate chain (LIC) is a subunit unique to the cytoplasmic form of dynein, but how it contributes to dynein function is not fully understood. Previous work has established that the LIC homodimer binds directly to the dynein heavy chain and may mediate the attachment of dynein to centrosomes and o...

journal_title：Molecular biology of the cell

authors： Mische S,He Y,Ma L,Li M,Serr M,Hays TS

更新日期：2008-11-01 00:00:00

abstract：:The E3 ubiquitin ligase Rad18 chaperones DNA polymerase η (Polη) to sites of UV-induced DNA damage and monoubiquitinates proliferating cell nuclear antigen (PCNA), facilitating engagement of Polη with stalled replication forks and promoting translesion synthesis (TLS). It is unclear how Rad18 activities are coordinate...

journal_title：Molecular biology of the cell

authors： Barkley LR,Palle K,Durando M,Day TA,Gurkar A,Kakusho N,Li J,Masai H,Vaziri C

更新日期：2012-05-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) accessory protein Nef directs virus escape from immune surveillance by subverting host cell intracellular signaling and membrane traffic to down-regulate cell-surface major histocompatibility complex class I (MHC-I). The interaction of Nef with the sorting proteins PACS-...

journal_title：Molecular biology of the cell

authors： Dikeakos JD,Thomas L,Kwon G,Elferich J,Shinde U,Thomas G

更新日期：2012-06-01 00:00:00

abstract：:TPA-inducible sequence 11b/butyrate response factor 1 (TIS11b/BRF1) belongs to the tristetraprolin (TTP) family of zinc-finger proteins, which bind to mRNAs containing AU-rich elements in their 3'-untranslated region and target them for degradation. Regulation of TTP family function through phosphorylation by p38 MAP ...

journal_title：Molecular biology of the cell

authors： Rataj F,Planel S,Desroches-Castan A,Le Douce J,Lamribet K,Denis J,Feige JJ,Cherradi N

更新日期：2016-12-01 00:00:00

abstract：:Telomerase is a ribonucleoprotein enzyme that counteracts replicative telomere erosion by adding telomeric sequence repeats onto chromosome ends. Despite its well-established role in telomere synthesis, telomerase has not yet been detected at telomeres. The RNA component of human telomerase (hTR) resides in the nucleo...

journal_title：Molecular biology of the cell

authors： Jády BE,Richard P,Bertrand E,Kiss T

更新日期：2006-02-01 00:00:00

abstract：:Drosophila myosin IB (Myo1B) is one of two class I myosins in the Drosophila genome. In the larval and adult midgut enterocyte, Myo1B is present within the microvillus (MV) of the apical brush border (BB) where it forms lateral tethers between the MV membrane and underlying actin filament core. Expression of green flu...

journal_title：Molecular biology of the cell

authors： Hegan PS,Mermall V,Tilney LG,Mooseker MS

更新日期：2007-11-01 00:00:00

abstract：:Ca(2+) is absorbed across intestinal epithelial monolayers via transcellular and paracellular pathways, and an active form of vitamin D(3), 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)], is known to promote intestinal Ca(2+) absorption. However, the molecules driving the paracellular Ca(2+) absorption and its...

journal_title：Molecular biology of the cell

authors： Fujita H,Sugimoto K,Inatomi S,Maeda T,Osanai M,Uchiyama Y,Yamamoto Y,Wada T,Kojima T,Yokozaki H,Yamashita T,Kato S,Sawada N,Chiba H

更新日期：2008-05-01 00:00:00

abstract：:Clathrin-mediated endocytosis regulates the internalization of many nutrient and signaling receptors. Clathrin and endocytic accessory proteins are recruited to receptors by specific adaptors. The adaptor Disabled-2 (Dab2) recruits its cargoes, including the low-density lipoprotein receptor (LDLR), and mediates endocy...

journal_title：Molecular biology of the cell

authors： Mulkearns EE,Cooper JA

更新日期：2012-04-01 00:00:00

abstract：:Myo1c is a member of the myosin superfamily that binds phosphatidylinositol-4,5-bisphosphate (PIP(2)), links the actin cytoskeleton to cellular membranes and plays roles in mechano-signal transduction and membrane trafficking. We located and characterized two distinct membrane binding sites within the regulatory and t...

journal_title：Molecular biology of the cell

authors： Hokanson DE,Laakso JM,Lin T,Sept D,Ostap EM

更新日期：2006-11-01 00:00:00

abstract：:Yeast and vertebrate nuclear pores display significant morphological similarity by electron microscopy, but sequence similarity between the respective proteins has been more difficult to observe. Herein we have identified a vertebrate nucleoporin, Nup93, in both human and Xenopus that has proved to be an evolutionaril...

journal_title：Molecular biology of the cell

authors： Grandi P,Dang T,Pané N,Shevchenko A,Mann M,Forbes D,Hurt E

更新日期：1997-10-01 00:00:00

abstract：:Low molecular weight (LMW) GTP-binding proteins are hypothesized to play a role in the vectorial transport of intracellular vesicles. Mutational studies in yeast and subcellular localization in mammalian cells suggest that a family of LMW GTP-binding proteins, termed rab, target intracellular vesicles to their appropr...

journal_title：Molecular biology of the cell

authors： Ngsee JK,Fleming AM,Scheller RH

更新日期：1993-07-01 00:00:00

abstract：:Binding of echovirus 1 (EV1, a nonenveloped RNA virus) to the alpha2beta1 integrin on the cell surface is followed by endocytic internalization of the virus together with the receptor. Here, video-enhanced live microscopy revealed the rapid uptake of fluorescently labeled EV1 into mobile, intracellular structures, pos...

journal_title：Molecular biology of the cell

authors： Pietiäinen V,Marjomäki V,Upla P,Pelkmans L,Helenius A,Hyypiä T

更新日期：2004-11-01 00:00:00

abstract：:In mouse embryoid bodies, mutation of the tight junction protein cingulin results in changes in gene expression. Here, we studied the function of cingulin using a gene silencing approach in Madin-Darby canine kidney (MDCK) cells. Cingulin-depleted cells show higher protein and mRNA levels of claudin-2 and ZO-3, increa...

journal_title：Molecular biology of the cell

authors： Guillemot L,Citi S

更新日期：2006-08-01 00:00:00

abstract：:Microtubule (MT) organization is essential for many cellular events, including mitosis, migration, and cell polarity. Fidgetin (Fign), an ATP-dependent, MT-severing protein, contributes to the regulation of MT configuration by cutting and trimming MT polymers. Functions of Fign have been indicated in neurite outgrowth...

journal_title：Molecular biology of the cell

authors： Hu Z,Feng J,Bo W,Wu R,Dong Z,Liu Y,Qiang L,Liu M

更新日期：2017-02-15 00:00:00

abstract：:The Rho family of GTP-binding proteins plays a critical role in a variety of cellular processes, including cytoskeletal reorganization and activation of kinases such as p38 and C-jun N-terminal kinase (JNK) MAPKs. We report here that dominant negative forms of Rac1 and Cdc42Hs inhibit the expression of the muscle-spec...

journal_title：Molecular biology of the cell

authors： Meriane M,Roux P,Primig M,Fort P,Gauthier-Rouvière C

更新日期：2000-08-01 00:00:00

abstract：:Arg8-vasopressin (AVP) promotes the differentiation of myogenic cell lines and mouse primary satellite cells by mechanisms involving the transcriptional activation of myogenic bHLH regulatory factors and myocyte enhancer factor 2 (MEF2). We here report that AVP treatment of L6 cells results in the activation of calcin...

journal_title：Molecular biology of the cell

authors： Scicchitano BM,Spath L,Musarò A,Molinaro M,Rosenthal N,Nervi C,Adamo S

更新日期：2005-08-01 00:00:00

abstract：:Clathrin-mediated endocytosis (CME) is facilitated by a precisely regulated burst of actin assembly. PtdIns(4,5)P2 is an important signaling lipid with conserved roles in CME and actin assembly regulation. Rhomboid family multipass transmembrane proteins regulate diverse cellular processes; however, rhomboid-mediated ...

journal_title：Molecular biology of the cell

authors： Cortesio CL,Lewellyn EB,Drubin DG

更新日期：2015-04-15 00:00:00

abstract：:The mechanisms and receptors involved in phagocytosis by nonhematopoietic cells are not well understood. The involvement of the alpha 3 beta 1 integrin in phagocytosis of the extracellular matrix by human breast cancer cells was studied. The possible role of this integrin was suggested since alpha 3 and beta 1 but not...

journal_title：Molecular biology of the cell

authors： Coopman PJ,Thomas DM,Gehlsen KR,Mueller SC

更新日期：1996-11-01 00:00:00

abstract：:Autophagy is a central homeostasis and stress response pathway conserved in all eukaryotes. One hallmark of autophagy is the de novo formation of autophagosomes. These double-membrane vesicular structures form around and deliver cargo for degradation by the vacuole/lysosome. Where and how autophagosomes form are outst...

journal_title：Molecular biology of the cell

authors： Graef M,Friedman JR,Graham C,Babu M,Nunnari J

更新日期：2013-09-01 00:00:00

abstract：:In autosomal dominant polycystic kidney disease (ADPKD), cysts accumulate and progressively impair renal function. Mutations in PKD1 and PKD2 genes are causally linked to ADPKD, but how these mutations drive cell behaviors that underlie ADPKD pathogenesis is unknown. Human ADPKD cysts frequently express cadherin-8 (ca...

journal_title：Molecular biology of the cell

authors： Belmonte JM,Clendenon SG,Oliveira GM,Swat MH,Greene EV,Jeyaraman S,Glazier JA,Bacallao RL

更新日期：2016-11-07 00:00:00