Prevalence of Helicobacter pylori in gastric cancer in a South-East Asian population by 14C-urea breath test.

Abstract:

BACKGROUND:Helicobacter pylori is believed to play an important role in the aetiology of gastric cancer. There is a great variability in seropositivity and histological frequency of H. pylori in gastric cancer. The present prospective study investigates the prevalence of H. pylori infection in gastric cancer patients using 14C-urea breath testing. METHODS:Patients with endoscopic biopsy-proven gastric cancer were fasted for 6 h prior to ingesting 18.5 x 104 Bq of 14C-urea cocktail orally. Breath samples were collected after 20 min by asking them to blow into a hyamine solution and measurements were read in a scintillation counter. RESULTS:Fifty out of 51 patients (98%) with gastric cancer were positive on the 14C-urea breath test compared to 29 patients (61%) who were positive on histology. There was no association between sex, age or tumour site, stage, differentiation, Lauren type and H. pylori status. The test was negative in one patient with cardial tumour in which histology of the resected specimen was also negative for the bacteria. CONCLUSIONS:Active H. pylori infection is highly prevalent in gastric cancer in a South-East Asian population. The 14C-urea breath test is a highly sensitive method for detecting the presence of H. pylori even in gastric adenocarcinoma irrespective of the stage.

journal_name

ANZ J Surg

journal_title

ANZ journal of surgery

authors

Chung AY,Chow PK,Yu WK,Ho JM,Chan HS,Wong WK,Soo KC

doi

10.1046/j.1445-2197.2001.02208.x

keywords:

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

574-6

issue

10

eissn

1445-1433

issn

1445-2197

pii

ans2208

journal_volume

71

pub_type

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