The threshold model as a general purpose normalizing transformation.

Abstract:

:The estimation of heritabilities and genetic correlations is based on the assumption that the trait distributions are normal. When the distributions are not normal it is advisable to transform the data to produce normality. However, it is possible that no suitable transformation can be found. The purpose of the present paper is to point out that the threshold model of quantitative genetics can be used as a generalized transformation. To utilize this method it is only necessary to divide the data at the median (approximately) and code the two halves as 0 and 1. Estimates can then be made using algorithms outlined herein. A simulation study shows that the threshold transformation gave unbiased estimates of the heritability and genetic correlation in all cases. The 95% confidence limits correctly included the true heritability value in the required 95% of cases, while the estimated confidence region for the genetic correlation was also correct provided that the geometric mean heritability was greater than approximately 0.15, a restriction that applied also to the normally distributed data. Confidence intervals estimated from the non-normal data were consistently too small. The method is illustrated using data on the proportion of diapausing eggs produced by the cricket, Allonemobius socius.

journal_name

Heredity (Edinb)

journal_title

Heredity

authors

Roff DA

doi

10.1046/j.1365-2540.2001.00844.x

keywords:

subject

Has Abstract

pub_date

2001-04-01 00:00:00

pages

404-11

issue

Pt 4

eissn

0018-067X

issn

1365-2540

pii

her844

journal_volume

86

pub_type

杂志文章

相关文献

HEREDITY文献大全
  • Natural selection and genetic differentiation of behaviour between parasitoids from wild and cultivated habitats

    abstract::Differences in behaviour between individuals in populations living in different environments may result from evolution proceeding differently in each population. The parasitoid wasp Cotesia glomerata (L.) (Hymenoptera: Braconidae) parasitizes early instar larvae of butterflies in the family Pieridae. In the study area...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1046/j.1365-2540.1999.00549.x

    authors: Nouhuys SV,Via S

    更新日期:1999-08-01 00:00:00

  • Dosage effects on heritability and maternal effects in diploid and triploid Chinook salmon (Oncorhynchus tshawytscha).

    abstract::Induced triploidy (3N) in salmon results from a blockage of maternal meiosis II, and hence provides a unique opportunity to study dosage effects on phenotypic variance. Chinook salmon families were bred using a paternal half-sib breeding design (62 females and 31 males) and half of each resulting family was treated to...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/sj.hdy.6800941

    authors: Johnson RM,Shrimpton JM,Cho GK,Heath DD

    更新日期:2007-05-01 00:00:00

  • Cooperation and conflict in the evolution of multicellularity.

    abstract::Multicellular organisms probably originated as groups of cells formed in several ways, including cell proliferation from a group of founder cells and aggregation. Cooperation among cells benefits the group, but may be costly (altruistic) or beneficial (synergistic) to individual cooperating cells. In this paper, we st...

    journal_title:Heredity

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2540.2001.00808.x

    authors: Michod RE,Roze D

    更新日期:2001-01-01 00:00:00

  • Evidence for contrasting modes of selection at interacting globin genes in the European rabbit (Oryctolagus cuniculus).

    abstract::In hybrid zones between genetically differentiated populations, variation in locus-specific rates of introgression may reflect adaptation to different environments or adaptation to different genetic backgrounds. The European rabbit, Oryctolagus cuniculus, is well-suited to studies of such hybrid zone dynamics because ...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/hdy.2008.26

    authors: Campos R,Storz JF,Ferrand N

    更新日期:2008-06-01 00:00:00

  • Chromosomal localization of cotransformed transgenes in the hexaploid cultivated oat Avena sativa L. using fluorescence in situ hybridization.

    abstract::Fluorescence in situ hybridization (FISH) was used to localize two transgenes (gus and bar), carried on plasmids pACT-1F and pUBA, respectively, on mitotic metaphase squashes of T1 plants of the cultivated hexaploid oat Avena sativa L. cotransformed by microprojectile bombardment of embryogenic callus. Among the eight...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1046/j.1365-2540.2000.00627.x

    authors: Leggett JM,Perret SJ,Harper J,Morris P

    更新日期:2000-01-01 00:00:00

  • Colonization patterns of the invasive Brazilian peppertree, Schinus terebinthifolius, in Florida.

    abstract::Invasive species are believed to spread through a process of stratified dispersal consisting of short-distance diffusive spread around established foci and human mediated long-distance jumps. Brazilian peppertree (Schinus terebinthifolius), native to South America, was introduced twice as an ornamental plant into Flor...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/sj.hdy.6800936

    authors: Williams DA,Muchugu E,Overholt WA,Cuda JP

    更新日期:2007-05-01 00:00:00

  • Demographic history and the low genetic diversity in Dipteryx alata (Fabaceae) from Brazilian Neotropical savannas.

    abstract::Genetic effects of habitat fragmentation may be undetectable because they are generally a recent event in evolutionary time or because of confounding effects such as historical bottlenecks and historical changes in species' distribution. To assess the effects of demographic history on the genetic diversity and populat...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/hdy.2013.23

    authors: Collevatti RG,Telles MP,Nabout JC,Chaves LJ,Soares TN

    更新日期:2013-08-01 00:00:00

  • A genetic analysis of reproductive barriers in Phacelia dubia.

    abstract::Investigations into the genetic basis of reproductive barriers among recognized and putative varieties in Phacelia dubia have provided evidence that even among closely related taxa, multiple pathways can lead to reproductive isolation. A nuclear-based reproductive barrier, expressed as partial hybrid sterility of both...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/hdy.1991.97

    authors: Levy F

    更新日期:1991-12-01 00:00:00

  • Genetic variation and constraints on the evolution of defense against spittlebug (Philaenus spumarius) herbivory in Mimulus guttatus.

    abstract::Plants mediate carbon into most ecosystems and are thus under persistent attack by diverse enemies. The evolution of defense against such assaults will depend on the availability of genetic variation, as well as the costs and constraints on defense. We estimated the magnitude of genetic variation for defense against s...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/hdy.2008.122

    authors: Ivey CT,Carr DE,Eubanks MD

    更新日期:2009-03-01 00:00:00

  • Enhancing genetic disease control by selecting for lower host infectivity and susceptibility.

    abstract::Infectious diseases have a huge impact on animal health, production and welfare, and human health. Understanding the role of host genetics in disease spread is important for developing disease control strategies that efficiently reduce infection incidence and risk of epidemics. While heritable variation in disease sus...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/s41437-018-0176-9

    authors: Tsairidou S,Anacleto O,Woolliams JA,Doeschl-Wilson A

    更新日期:2019-06-01 00:00:00

  • Molecular ecology meets remote sensing: environmental drivers to population structure of humpback dolphins in the Western Indian Ocean.

    abstract::Genetic analyses of population structure can be placed in explicit environmental contexts if appropriate environmental data are available. Here, we use high-coverage and high-resolution oceanographic and genetic sequence data to assess population structure patterns and their potential environmental influences for hump...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/hdy.2011.21

    authors: Mendez M,Subramaniam A,Collins T,Minton G,Baldwin R,Berggren P,Särnblad A,Amir OA,Peddemors VM,Karczmarski L,Guissamulo A,Rosenbaum HC

    更新日期:2011-10-01 00:00:00

  • Genetic variation in the invasive process of Bursaphelenchus xylophilus (Aphelenchida: Aphelenchoididae) and its possible spread routes in China.

    abstract::Pinewood nematode (Bursaphelenchus xylophilus) is an invasive species that causes a destructive forest disease-pine wilt disease. This disease has been prevalent in some countries in Asia since the 1970s. An amplified fragment length polymorphism survey was used to compare the genetic variation of native and invasive ...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/sj.hdy.6801082

    authors: Cheng XY,Cheng FX,Xu RM,Xie BY

    更新日期:2008-04-01 00:00:00

  • Chiasma frequency variation with altitude in Cepaea hortensis (můll.).

    abstract::Populations of Cepaea hortensis have been sampled from an area of 121 sq km on the north slopes of the Brendon Hills, Somerset, and analysed for chiasma frequency. Variation in chiasma frequency is due to variation in a single large bivalent--the A group bivalent. In 12 populations studied during 1973 no association b...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/hdy.1975.86

    authors: Price DJ

    更新日期:1975-10-01 00:00:00

  • Selection under negative linkage disequilibrium. Random mating versus inbreeding.

    abstract::A population resulting from the diallel cross of a set of elite inbred lines was selected under two strategies: (i) inbred strategy (IS) under brother-sister mating; and (ii) random strategy (RIS) under random mating. The final lines in both cases were completely inbred. RIS populations clearly responded better than I...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1046/j.1365-2540.1999.00520.x

    authors: Silvela L,de la Peña ID,Gomez-Ruano R

    更新日期:1999-06-01 00:00:00

  • Genetic differentiation and habitat preference of flowering-time variants within Gymnadenia conopsea.

    abstract::Using fast-evolving microsatellites, more slowly evolving ITS markers and performing habitat analyses, we demonstrated a drastic genetic divergence and significant habitat differentiation between early- and late-flowering variants of plants morphologically belonging to Gymnadenia conopsea ssp conopsea. The two phenolo...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/sj.hdy.6800334

    authors: Gustafsson S,Lönn M

    更新日期:2003-09-01 00:00:00

  • Genetic heterogeneity underlying variation in a locally adaptive clinal trait in Pinus sylvestris revealed by a Bayesian multipopulation analysis.

    abstract::Local adaptation is a common feature of plant and animal populations. Adaptive phenotypic traits are genetically differentiated along environmental gradients, but the genetic basis of such adaptation is still poorly known. Genetic association studies of local adaptation combine data over populations. Correcting for po...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/hdy.2016.115

    authors: Kujala ST,Knürr T,Kärkkäinen K,Neale DB,Sillanpää MJ,Savolainen O

    更新日期:2017-05-01 00:00:00

  • Short distance pollen dispersal and low genetic diversity in a subcanopy tropical rainforest tree, Fontainea picrosperma (Euphorbiaceae).

    abstract::Gene flow via pollen movement affects genetic variation in plant populations and is an important consideration in plant domestication. Fontainea picrosperma is a subcanopy rainforest tree that is of commercial interest because it is the source of tigilanol tiglate, a natural product used for the treatment of solid tum...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/s41437-019-0231-1

    authors: Grant EL,Conroy GC,Lamont RW,Reddell PW,Wallace HM,Ogbourne SM

    更新日期:2019-10-01 00:00:00

  • Why are individuals so different from each other?

    abstract::An important contributor to the differences between individuals derives from their plasticity. Such plasticity is widespread in organisms from the simple to the most complex. Adaptability plasticity enables the organism to cope with a novel challenge not previously encountered by its ancestors. Conditional plasticity ...

    journal_title:Heredity

    pub_type: 杂志文章,评审

    doi:10.1038/hdy.2014.103

    authors: Bateson P

    更新日期:2015-10-01 00:00:00

  • Exploring neutral and adaptive processes in expanding populations of gilthead sea bream, Sparus aurata L., in the North-East Atlantic.

    abstract::Recent studies in empirical population genetics have highlighted the importance of taking into account both neutral and adaptive genetic variation in characterizing microevolutionary dynamics. Here, we explore the genetic population structure and the footprints of selection in four populations of the warm-temperate co...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/hdy.2011.120

    authors: Coscia I,Vogiatzi E,Kotoulas G,Tsigenopoulos CS,Mariani S

    更新日期:2012-05-01 00:00:00

  • Effect of inbreeding and heritability of sperm competition success in the bulb mite Rhizoglyphus robini.

    abstract::Sperm competition is a potent evolutionary force shaping the reproductive biology of most animal species. Here, we estimated the heritability of sperm competition success in the promiscuous bulb mite Rhizoglyphus robini. Sperm competition success was measured with the sterile male technique as the proportion of eggs f...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/sj.hdy.6800649

    authors: Konior M,Keller L,Radwan J

    更新日期:2005-06-01 00:00:00

  • Vertical transmission of Wolbachia in Tetranychus kanzawai Kishida and Panonychus mori Yokoyama (Acari: Tetranychidae).

    abstract::The vertical transmission of Wolbachia in two species of spider mite was investigated and compared. One species, Tetranychus kanzawai Kishida, was infected with a modification negative strain of Wolbachia while the other species, Panonychus mori Yokoyama, was infected with a modification positive strain. The infection...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/sj.hdy.6800026

    authors: Hong XY,Gotoh T,Nagata T

    更新日期:2002-03-01 00:00:00

  • nrDNA:mtDNA copy number ratios as a comparative metric for evolutionary and conservation genetics.

    abstract::Identifying genetic cues of functional relevance is key to understanding the drivers of evolution and increasingly important for the conservation of biodiversity. This study introduces nuclear ribosomal DNA (nrDNA) to mitochondrial DNA (mtDNA) copy number ratios as a metric with which to screen for this functional gen...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/s41437-018-0088-8

    authors: Goodall-Copestake WP

    更新日期:2018-08-01 00:00:00

  • Genealogy of the nuclear beta-fibrinogen locus in a highly structured lizard species: comparison with mtDNA and evidence for intragenic recombination in the hybrid zone.

    abstract::The study of nuclear genealogies in natural populations of nonmodel organisms is expected to provide novel insights into the evolutionary history of populations, especially when developed in the framework of well-established mtDNA phylogeographical scenarios. In the Iberian Peninsula, the endemic Schreiber's green liz...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/sj.hdy.6800823

    authors: Godinho R,Mendonça B,Crespo EG,Ferrand N

    更新日期:2006-06-01 00:00:00

  • Incorporating the single-step strategy into a random regression model to enhance genomic prediction of longitudinal traits.

    abstract::In prediction of genomic values, the single-step method has been demonstrated to outperform multi-step methods. In statistical analyses of longitudinal traits, the random regression test-day model (RR-TDM) has clear advantages over other models. Our goal in this study was to evaluate the performance of a model that in...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/hdy.2016.91

    authors: Kang H,Zhou L,Mrode R,Zhang Q,Liu JF

    更新日期:2017-12-01 00:00:00

  • On the developmental theory of ageing. II. The effect of developmental temperature on longevity in relation to adult body size in D. melanogaster.

    abstract::Flies from a wild type strain of Drosophila melanogaster, previously kept at 25 degrees C, were reared at either 20, 25 or 29 degrees C. As expected, developmental time and adult body size decreased with increasing temperature. Adult longevity of flies reared at 25 degrees C was slightly greater than that of flies rai...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:

    authors: Zwaan BJ,Bijlsma R,Hoekstra RF

    更新日期:1992-02-01 00:00:00

  • Linkage disequilibrium between the pseudoautosomal PEPB-1 locus and the sex-determining region of chinook salmon.

    abstract::Allele frequency differences between sexes and an excess of heterozygotes in males had suggested that the PEPB-1 locus is sex-linked in chinook salmon (Oncorhynchus tshawytscha). We here estimate less than 1% recombination between PEPB-1 and a growth hormone pseudogene known to be in the sex-determining region (SEX) i...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/sj.hdy.6800483

    authors: Marshall AR,Knudsen KL,Allendorf FW

    更新日期:2004-07-01 00:00:00

  • Selection on olfactory response to semiochemicals from a plant-host complex in a parasitic wasp.

    abstract::Parasitic wasps (parasitoids) use volatiles from the plants infested by phytophagous insects to locate host herbivores, but their behavioural response to such semiochemicals is highly variable. Bi-directional selection on Cotesia glomerata (Hymenoptera: Braconidae) was conducted to investigate the importance of geneti...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/sj.hdy.6800340

    authors: Wang Q,Gu H,Dorn S

    更新日期:2003-10-01 00:00:00

  • Insights into the genetic architecture of morphological traits in two passerine bird species.

    abstract::Knowledge about the underlying genetic architecture of phenotypic traits is needed to understand and predict evolutionary dynamics. The number of causal loci, magnitude of the effects and location in the genome are, however, still largely unknown. Here, we use genome-wide single-nucleotide polymorphism (SNP) data from...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/hdy.2017.29

    authors: Silva CNS,McFarlane SE,Hagen IJ,Rönnegård L,Billing AM,Kvalnes T,Kemppainen P,Rønning B,Ringsby TH,Sæther BE,Qvarnström A,Ellegren H,Jensen H,Husby A

    更新日期:2017-09-01 00:00:00

  • Inheritance of thelytoky in the honey bee Apis mellifera capensis.

    abstract::Asexual reproduction via thelytokous parthenogenesis is widespread in the Hymenoptera, but its genetic underpinnings have been described only twice. In the wasp Lysiphlebus fabarum and the Cape honey bee Apis mellifera capensis the origin of thelytoky have each been traced to a single recessive locus. In the Cape hone...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/hdy.2014.127

    authors: Chapman NC,Beekman M,Allsopp MH,Rinderer TE,Lim J,Oxley PR,Oldroyd BP

    更新日期:2015-06-01 00:00:00

  • Further investigation on the regression method of mapping quantitative trait loci.

    abstract::The simple regression method of mapping quantitative trait loci (QTL) is further investigated in comparison with the mixture model maximum likelihood method under high heritabilities, dominant and missing markers. No significant difference between the two methods is detected in terms of errors of parameter estimation ...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1046/j.1365-2540.1998.00307.x

    authors: Xu S

    更新日期:1998-03-01 00:00:00