Progression to acquired immunodeficiency syndrome in 94 human immunodeficiency virus-positive hemophiliacs with long-term follow-up.

abstract：:To further clarify the role of ribosomal protein S14 (RPS14) in myelodysplastic syndrome, we examined RPS14 transcription in bone marrow derived CD34+ cells from patients with non-5q- myelodysplastic syndrome and found a reduced expression of RPS14 in 51 of 72 (71%) patients. MDS patients with an intermediate-1 risk (...

journal_title：Haematologica

authors： Czibere A,Bruns I,Junge B,Singh R,Kobbe G,Haas R,Germing U

更新日期：2009-10-01 00:00:00

abstract：:Drug resistance impedes the long-term effect of targeted therapies in acute myeloid leukemia (AML), necessitating the identification of mechanisms underlying resistance. Approximately 25% of AML patients carry FLT3 mutations and develop post-treatment insensitivity to FLT3 inhibitors, including sorafenib. Using a geno...

journal_title：Haematologica

authors： Damnernsawad A,Bottomly D,Kurtz SE,Eide CA,McWeeney SK,Tyner JW,Nechiporuk T

更新日期：2020-12-30 00:00:00

abstract：:Multicytokine therapy may be useful to counteract radiation-induced myelosuppression. We assessed the stem cell factor + glycosylated erythropoietin + pegylated granulocyte colony-stimulating factor combination (SEG) as an emergency treatment. SEG in highly irradiated monkeys efficacy appeared to be restricted to gran...

journal_title：Haematologica

authors： Drouet M,Delaunay C,Grenier N,Garrigou P,Mayol JF,Hérodin F

更新日期：2008-03-01 00:00:00

abstract：:Seven cord blood (CB) units were tested for their capacity to repopulate irradiated NOD/SCID mice after one or two successive cryopreservation procedures. In primary transplants with frozen or refrozen CB cells we observed equivalent human colonies and percentages of human CD45+ cells, with multilineage engraftment. I...

journal_title：Haematologica

authors： Timeus F,Crescenzio N,Sanavio F,Fazio L,Doria A,Foglia L,Pignochino Y,Berger M,Piacibello W,Madon E,Cordero di Montezemolo L,Fagioli F

更新日期：2006-03-01 00:00:00

abstract：:Mastocytosis is a rare and chronic disease with phenotypes ranging from indolent to severe. Prognosis for this disease is variable and very few biomarkers to predict disease evolution or outcome are currently known. We have performed comprehensive screening in our large cohort of mastocytosis patients for mutations pr...

journal_title：Haematologica

authors： Hanssens K,Brenet F,Agopian J,Georgin-Lavialle S,Damaj G,Cabaret L,Chandesris MO,de Sepulveda P,Hermine O,Dubreuil P,Soucie E

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Mesenchymal stem cells (MSC) are progenitor cells that are capable of differentiating into mesenchymal tissues. Fetal and adult MSC have similar morphology but differ in proliferative, differentiating and immunosuppressive properties. Further exploring their differences could help in choosing ...

journal_title：Haematologica

authors： Götherström C,West A,Liden J,Uzunel M,Lahesmaa R,Le Blanc K

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Subgroups of T-cell acute lymphoblastic leukemia (T-ALL), defined according to recurrent cytogenetic aberrations, may have different prognoses. The aim of this study was to determine the prognostic relevance of molecular-cytogenetic abnormalities in pediatric patients using quantitative real-t...

journal_title：Haematologica

authors： van Grotel M,Meijerink JP,Beverloo HB,Langerak AW,Buys-Gladdines JG,Schneider P,Poulsen TS,den Boer ML,Horstmann M,Kamps WA,Veerman AJ,van Wering ER,van Noesel MM,Pieters R

更新日期：2006-09-01 00:00:00

abstract：:The balance between self-renewal and differentiation is crucial to ensure the homeostasis of the hematopoietic system, and is a hallmark of hematopoietic stem cells. However, the underlying molecular pathways, including the role of micro-RNA, are not completely understood. To assess the contribution of micro-RNA, we p...

journal_title：Haematologica

authors： Crisafulli L,Muggeo S,Uva P,Wang Y,Iwasaki M,Locatelli S,Anselmo A,Colombo FS,Carlo-Stella C,Cleary ML,Villa A,Gentner B,Ficara F

更新日期：2019-09-01 00:00:00

abstract：:In the European Intergroup EURO-LB02 trial, children and adolescents with lymphoblastic lymphoma underwent the non-Hodgkin lymphoma Berlin-Frankfurt-Münster protocol without prophylactic cranial radiotherapy. The primary aims of this trial were to test whether replacing prednisone with dexamethasone during induction i...

journal_title：Haematologica

authors： Landmann E,Burkhardt B,Zimmermann M,Meyer U,Woessmann W,Klapper W,Wrobel G,Rosolen A,Pillon M,Escherich G,Attarbaschi A,Beishuizen A,Mellgren K,Wynn R,Ratei R,Plesa A,Schrappe M,Reiter A,Bergeron C,Patte C,Bertran

更新日期：2017-12-01 00:00:00

abstract：:Fludarabine (FLU) is a new antimetabolite chemotherapeutic agent with promising activity in lymphoproliferative disorders and, in particular, in low-grade non-Hodgkin's lymphoma (LG-NHL). Recently, a few reports have described interesting results using FLU in polychemotherapy regimens. In order to evaluate FLU in comb...

journal_title：Haematologica

authors： Zinzani PL,Bendandi M,Gherlinzoni F,Merla E,Gozzetti A,Tura S

更新日期：1996-03-01 00:00:00

abstract：:Diagnostic biomarkers can be used to determine relapse risk in acute myeloid leukemia, and certain genetic aberrancies have prognostic relevance. A diagnostic immunophenotypic expression profile, which quantifies the amounts of distinct gene products, not just their presence or absence, was established in order to imp...

journal_title：Haematologica

authors： Voigt AP,Brodersen LE,Alonzo TA,Gerbing RB,Menssen AJ,Wilson ER,Kahwash S,Raimondi SC,Hirsch BA,Gamis AS,Meshinchi S,Wells DA,Loken MR

更新日期：2017-12-01 00:00:00

abstract：:BCL11A was the focus of recent studies on its inhibiting effect when bound onto the β-globin cluster in the mechanism of hemoglobin switching and HbF downregulation. We examined a cohort of 10 patients displaying different HbF levels and short deletions within the γβ-δ intergenic region to find a possible correlation ...

journal_title：Haematologica

authors： Ghedira ES,Lecerf L,Faubert E,Costes B,Moradkhani K,Bachir D,Galactéros F,Pissard S

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Cord blood (CB) is a valuable source of stem cells. Most CB units are still cryopreserved in single bags in the world's CB banks. Thawing a single CB unit, dividing it into two parts, expanding the smaller one and refreezing the other would optimize ex vivo expansion of CB progenitors prior to...

journal_title：Haematologica

authors： Timeus F,Crescenzio N,Saracco P,Doria A,Fazio L,Albiani R,Cordero Di Montezemolo L,Perugini L,Incarbone E

更新日期：2003-01-01 00:00:00

abstract：:Plasma levels of several soluble factors were assayed in 31 untreated patients with high-grade non-Hodgkin's lymphomas (NHL). The results showed statistically significant higher average levels of interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-2 receptor (IL-2r) and transferrin receptor (...

journal_title：Haematologica

authors： Stasi R,Conforti M,Del Poeta G,Simone MD,Coppetelli U,Tribalto M,Cantonetti M,Perrotti A,Venditti A,Papa G

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:After allogeneic haematopoietic stem cell transplantation (SCT) the whole T-cell receptor (TCR) repertoire shows a markedly skewed pattern for 2-3 years. A small fraction of CD4+ T cells is represented by CD25+ regulatory lymphocytes (Treg), which play a crucial role in modulating peripheral t...

journal_title：Haematologica

authors： Fozza C,Nadal E,Longinotti M,Dazzi F

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Diffuse large B-cell lymphomas (DLBCL) have a variable outcome, and powerful methods of prognostication are needed in order to choose the best treatment for each patient. Immunophenotypic classification of the tumor as germinal center (GC) or non-germinal center-like (nGC) and early response e...

journal_title：Haematologica

authors： Dupuis J,Gaulard P,Hemery F,Itti E,Gisselbrecht C,Rahmouni A,Copie-Bergman C,Brière J,El Gnaoui T,Gaillard I,Meignan M,Haioun C

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:The suppression of Ph1-positive hemopoiesis is a major goal in the treatment of CML; in this context the CML patients in blast crisis obtaining a complete clinical remission represent a useful model to investigate the behavior of the Ph1-positive and negative clones during bone marrow repopulation after abla...

journal_title：Haematologica

authors： Guerrasio A,Martinelli G,Ambrosetti A,Falda M,Paolino F,Rege-Cambrin G,Rosso C,Pignatti PF,Gasparini P,Perona G

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:In normal platelets, insulin inhibits agonist-induced Ca(2+) mobilization by raising cyclic AMP. Platelet from patients with type 2 diabetes are resistant to insulin and show increased Ca(2+) mobilization, aggregation and procoagulant activity. We searched for the cause of this insulin resistance. DESIGN AN...

journal_title：Haematologica

authors： Gerrits AJ,Gitz E,Koekman CA,Visseren FL,van Haeften TW,Akkerman JW

更新日期：2012-08-01 00:00:00

abstract：:A case of stiff-man syndrome (SMS), a rare and dramatic CNS disease characterized by continuous muscle activity and painful spasms resembling a chronic form of tetanus, occurring in a patient with Hodgkin's disease (HD) is reported. The patient developed the clinical features of SMS at the same time as the HD relapse....

journal_title：Haematologica

authors： Ferrari P,Federico M,Grimaldi LM,Silingardi V

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:Relapsing primary central nervous system lymphoma carries a poor prognosis when treated with conventional chemotherapy with a one-year overall survival of 25-40%. Encouraging results have been shown with intensive chemotherapy followed by autologous hematopoietic stem cell rescue. We report the results of a ...

journal_title：Haematologica

authors： Soussain C,Choquet S,Fourme E,Delgadillo D,Bouabdallah K,Ghesquières H,Damaj G,Dupriez B,Vargaftig J,Gonzalez A,Houillier C,Taillandier L,Hoang-Xuan K,Leblond V

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Vgamma9Vdelta2 T lymphocytes are regarded as promising mediators of cancer immunotherapy due to their capacity to eliminate multiple experimental tumors, particularly within those of hematopoietic origin. However, Vgamma9Vdelta2 T-cell based lymphoma clinical trials have suffered from the lack of biomarkers ...

journal_title：Haematologica

authors： Gomes AQ,Correia DV,Grosso AR,Lança T,Ferreira C,Lacerda JF,Barata JT,Silva MG,Silva-Santos B

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Identification and characterization of hematopoietic stem cells in peripheral blood (PB) and cord blood (CB) have suggested feasible alternatives to conventional allogeneic bone marrow (BM) transplantation. The growing interest in this use of allogeneic stem cells has prompted the Working Group...

journal_title：Haematologica

authors： Bertolini F,de Vincentiis A,Lanata L,Lemoli RM,Maccario R,Majolino I,Ponchio L,Rondelli D,Tabilio A,Zanon P,Tura S

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Recombinations are common between the two homologous alpha-globin genes. We report on the identification and characterization of two patchwork alpha-globin genes. DESIGN AND METHODS:Multiplex polymerase chain reaction assays were performed to rule out the presence of alpha-globin gene deletio...

journal_title：Haematologica

authors： Law HY,Luo HY,Wang W,Ho JF,Najmabadi H,Ng IS,Steinberg MH,Chui DH,Chong SS

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Patients with acute myeloblastic leukemia (AML) with features of myelodysplastic syndrome and abnormalities of megakaryocytopoiesis often have cytogenetic aberrations of 3q21 and 3q26 bands involving the paracentric inversion [inv(3) (q21q26)] or a reciprocal translocation [t(3;3) (q21;q26)]. ...

journal_title：Haematologica

authors： Martinelli G,Ottaviani E,Buonamici S,Isidori A,Borsaru G,Visani G,Piccaluga PP,Malagola M,Testoni N,Rondoni M,Nucifora G,Tura S,Baccarani M

更新日期：2003-11-01 00:00:00

abstract：:Clinical and hematologic characteristics of beta(β)-thalassemia are determined by several factors resulting in a wide spectrum of severity. Phenotype modulators are: HBB mutations, HBA defects and fetal hemoglobin production modulators (HBG2:g.-158C>T polymorphism, HBS1L-MYB intergenic region and the BCL11A). We chara...

journal_title：Haematologica

authors： Danjou F,Francavilla M,Anni F,Satta S,Demartis FR,Perseu L,Manca M,Sollaino MC,Manunza L,Mereu E,Marceddu G,Pissard S,Joly P,Thuret I,Origa R,Borg J,Forni GL,Piga A,Lai ME,Badens C,Moi P,Galanello R

更新日期：2015-04-01 00:00:00

abstract：:Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative/myelodysplastic disorder associated with mutations in the Ras-Raf-MEK-ERK-signaling pathway. B-Raf plays a central role in this pathway. In 65 screened JMML patients we identified no BRAF mutations and we conclude that this gene is unlikely to play a role...

journal_title：Haematologica

authors： de Vries AC,Stam RW,Kratz CP,Zenker M,Niemeyer CM,van den Heuvel-Eibrink MM,European Working Group on childhood MDS (EWOG-MDS).

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Oral deferiprone was suggested to be more effective than subcutaneous desferrioxamine for removing heart iron. Oral once-daily chelator deferasirox has recently been made commercially available but its long-term efficacy on cardiac iron and function has not yet been established. Our study aimed to compare th...

journal_title：Haematologica

authors： Pepe A,Meloni A,Capra M,Cianciulli P,Prossomariti L,Malaventura C,Putti MC,Lippi A,Romeo MA,Bisconte MG,Filosa A,Caruso V,Quarta A,Pitrolo L,Missere M,Midiri M,Rossi G,Positano V,Lombardi M,Maggio A

更新日期：2011-01-01 00:00:00

abstract：:T-cell acute lymphoblastic leukemia (T-ALL) patients frequently display NOTCH1 activating mutations and Notch can transcriptionally down-regulate the tumor suppressor PTEN. However, it is not clear whether NOTCH1 mutations associate with decreased PTEN expression in primary T-ALL. Here, we compared patients with or wi...

journal_title：Haematologica

authors： Silva A,Jotta PY,Silveira AB,Ribeiro D,Brandalise SR,Yunes JA,Barata JT

更新日期：2010-04-01 00:00:00

abstract：:Patients with chronic lymphocytic leukemia and unmutated immunoglobulin heavy-chain variable region gene (IGHV) have inferior survival from time of treatment in clinical studies. We assessed real-world outcomes based on mutational status and treatment regimen in a nationwide population-based cohort, comprising all 4,1...

journal_title：Haematologica

authors： Rotbain EC,Frederiksen H,Hjalgrim H,Rostgaard K,Egholm GJ,Zahedi B,Poulsen CB,Enggard L,da Cunha-Bang C,Niemann CU

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Macrophages of the reticuloendothelial system play a key role in recycling iron from hemoglobin of senescent or damaged erythrocytes. Heme oxygenase 1 degrades the heme moiety and releases inorganic iron that is stored in ferritin or exported to the plasma via the iron export protein ferroportin. In the plas...

journal_title：Haematologica

authors： Marro S,Chiabrando D,Messana E,Stolte J,Turco E,Tolosano E,Muckenthaler MU

更新日期：2010-08-01 00:00:00