A mutation of the Wilson disease protein, ATP7B, is degraded in the proteasomes and forms protein aggregates.

abstract：:Acute, acute recurrent, and chronic forms of pancreatitis have been increasingly diagnosed in children in the past 2 decades. Risk factors in the pediatric group are broad and appear to be strikingly different compared with the adult cohort. However, the disease burden and impact on quality of life are surprisingly si...

journal_title：Gastroenterology

authors： Uc A,Husain SZ

更新日期：2019-05-01 00:00:00

abstract：:The long term administration of chenodeoxycholic acid in man has to be regarded with caution because chenodeoxycholic acid has caused liver damage in various species of animals, including primates. To study the effect of three doses of chenodeoxycholic acid (10, 40, and 100 mg per kg per day) on hepatic function and m...

journal_title：Gastroenterology

authors： Dyrszka H,Salen G,Zaki FG,Chen T,Mosbach EH

更新日期：1976-01-01 00:00:00

abstract：BACKGROUND & AIMS:Neutrophils are generally thought to play an important proinflammatory role in the pathogenesis of inflammatory bowel disease. The objective of this study was to evaluate whether blocking the invasion of neutrophils by anti-L-selectin monoclonal antibodies modulates chemically induced colitis and how ...

journal_title：Gastroenterology

authors： Kühl AA,Kakirman H,Janotta M,Dreher S,Cremer P,Pawlowski NN,Loddenkemper C,Heimesaat MM,Grollich K,Zeitz M,Farkas S,Hoffmann JC

更新日期：2007-12-01 00:00:00

abstract：:Infliximab, the chimeric monoclonal immunoglobulin (Ig)G1 antibody to tumor necrosis factor (TNF) has changed our therapy of Crohn's disease. Infliximab is indicated in refractory luminal and fistulizing Crohn's disease. In patients with luminal disease, a single intravenous (i.v.) dose of 5 mg/kg is efficacious; in f...

journal_title：Gastroenterology

authors： Rutgeerts P,Van Assche G,Vermeire S

更新日期：2004-05-01 00:00:00

abstract：:Diverting the fecal stream has been considered to affect the course of Crohn's disease favorably. Adverse effects on the distal segment have not previously been distinguished from clinical signs and symptoms. The course of four patients with Crohn's disease who underwent fecal diversion with an in situ rectum were obs...

journal_title：Gastroenterology

authors： Korelitz BI,Cheskin LJ,Sohn N,Sommers SC

更新日期：1984-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Several studies suggest that statins prevent some cancers, with one study finding a 47% reduction in colorectal cancer risk after >or=5 years of regular use. METHODS:A nested case-control study was conducted within 454 general practices in the United Kingdom using the QRESEARCH database. Cases with...

journal_title：Gastroenterology

authors： Vinogradova Y,Hippisley-Cox J,Coupland C,Logan RF

更新日期：2007-08-01 00:00:00

abstract：:Behavioral economic approaches could increase uptake for colorectal cancer screening. We performed a randomized controlled trial of 2245 employees to determine whether an email containing a phone number for scheduling (control), an email with the active choice to opt in or opt out (active choice), or the active choice...

journal_title：Gastroenterology

authors： Mehta SJ,Feingold J,Vandertuyn M,Niewood T,Cox C,Doubeni CA,Volpp KG,Asch DA

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND & AIMS:Treatment options are limited for patients with hepatitis C (HCV) infection with treatment failure after sofosbuvir plus an NS5A inhibitor. There are some data for the efficacy of glecaprevir/pibrentasvir (G/P) in these patients. We performed a randomized trial of the safety and efficacy of 12 and 16 ...

journal_title：Gastroenterology

authors： Lok AS,Sulkowski MS,Kort JJ,Willner I,Reddy KR,Shiffman ML,Hassan MA,Pearlman BL,Hinestrosa F,Jacobson IM,Morelli G,Peter JA,Vainorius M,Michael LC,Fried MW,Wang GP,Lu W,Larsen L,Nelson DR

更新日期：2019-12-01 00:00:00

abstract：:The effect of aging on gastric and duodenal mucosal prostaglandins has not been reported. Gastric and duodenal mucosal prostaglandin concentrations were measured in 46 healthy adults, 35 of whom were relatively young (21-40 years old) and 11 of whom were considerably more elderly (aged 52-72 years). Mucosal biopsy spe...

journal_title：Gastroenterology

authors： Cryer B,Redfern JS,Goldschmiedt M,Lee E,Feldman M

更新日期：1992-04-01 00:00:00

abstract：:Serum gastrin and gastric endocrine cell numerical densities were examined in 22 patients with long-standing Zollinger-Ellison syndrome who were receiving either ranitidine, omeprazole, or other antisecretory drugs (SMS 201-995 or pirenzepine with or without ranitidine) for long periods of time. Fifteen patients had i...

journal_title：Gastroenterology

authors： Lehy T,Mignon M,Cadiot G,Elouaer-Blanc L,Ruszniewski P,Lewin MJ,Bonfils S

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND & AIMS:This study was undertaken to prospectively compare the clinical outcomes of small bowel radiographs with the wireless capsule endoscopy. METHODS:Twenty-two patients were selected consecutively because of suspected small bowel disease. Two patients were excluded owing to ileal stenosis. Thus, the resu...

journal_title：Gastroenterology

authors： Costamagna G,Shah SK,Riccioni ME,Foschia F,Mutignani M,Perri V,Vecchioli A,Brizi MG,Picciocchi A,Marano P

更新日期：2002-10-01 00:00:00

abstract：:Characteristics of a macroamylase that was considered not to be formed by the binding of normal amylase to immunoglobulins were studied. The macroamylase was reversibly dissociated into apparently normal amylase by treating the macroamylasemic serum with guanidine hydrochloride. Concanavalin A precipitated a large por...

journal_title：Gastroenterology

authors： Kitamura T,Yoshioka K,Ehara M,Akedo H

更新日期：1977-07-01 00:00:00

abstract：BACKGROUND/AIMS:Intestinal distention induces perception and gut reflexes via sympathetic and vagal pathways, but the modulatory mechanisms of such responses remain obscure. The aim of this study was to determine the effects of sympathetic nervous activity on sympathetic and vagal reflexes as well as on intestinal and ...

journal_title：Gastroenterology

authors： Iovino P,Azpiroz F,Domingo E,Malagelada JR

更新日期：1995-03-01 00:00:00

abstract：:Assessment of the influence of nutritional substrates on the disposition of ingested ethanol from the blood requires, first, an understanding of the influence that these may exert upon ethanol absorption from the gastrointestinal tract. In this report, the effects of various carbohydrates on the intestinal absorption ...

journal_title：Gastroenterology

authors： Broitman SA,Gottlieb LS,Vitale JJ

更新日期：1976-06-01 00:00:00

abstract：:Fifty-nine studies of gastrointestinal transit time were performed in 27 healthy women during pregnancy and postpartum. Gastrointestinal transit time was defined as the time of the first sustained rise in breath hydrogen concentration after ingestion of 10 g of lactulose. Gastrointestinal transit time was significantl...

journal_title：Gastroenterology

authors： Lawson M,Kern F Jr,Everson GT

更新日期：1985-11-01 00:00:00

abstract：:The subcellular localization of intraduodenally administered 59Fe has been studied in control, pregnant, and nonpregnant rats absorbing iron at different rates. Binding of iron to the particulate fractions of mucosal homogenates produced by centrifugation at 500, 10,000, and 100,000 X g did not vary among groups despi...

journal_title：Gastroenterology

authors： Batey RG,Gallagher ND

更新日期：1977-08-01 00:00:00

abstract：BACKGROUND & AIMS:The liver has high regenerative potential. We attempted to establish a novel culture system for extensive expansion of fetal mouse hepatic stem/progenitor cells and to characterize cultured cells. METHODS:Hepatic spheroids collected from 6-day floating cultures were cultured on collagen-coated dishes...

journal_title：Gastroenterology

authors： Tsuchiya A,Heike T,Fujino H,Shiota M,Umeda K,Yoshimoto M,Matsuda Y,Ichida T,Aoyagi Y,Nakahata T

更新日期：2005-06-01 00:00:00

abstract：:Approximately 5% of the world's human population have an increased risk for developing liver cancer and cirrhosis as a direct consequence of chronic infection with the hepatitis B virus (HBV). Antiviral chemotherapy remains the only option for controlling infection in these individuals, for whom the current licensed h...

journal_title：Gastroenterology

authors： Torresi J,Locarnini S

更新日期：2000-02-01 00:00:00

abstract：:We have prospectively evaluated 41 patients who ingested acid for location, extent, severity, and outcome of the injury to the upper gastrointestinal tract. The injury was assessed within 36 h of acid intake by endoscopy or surgery, or at autopsy. Symptoms and signs were unreliable in predicting the extent and severit...

journal_title：Gastroenterology

authors： Zargar SA,Kochhar R,Nagi B,Mehta S,Mehta SK

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND & AIMS:Interstitial cells of Cajal (ICC) serve as pacemaker cells and mediators of neurotransmission from the enteric nervous system to gastrointestinal muscles. ICC develop from mesenchymal cells that express c-Kit, and signaling via Kit receptors is necessary for normal development of ICC. We studied the f...

journal_title：Gastroenterology

authors： Torihashi S,Nishi K,Tokutomi Y,Nishi T,Ward S,Sanders KM

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND & AIMS:Hydrogen sulfide is one of the main malodorous compounds in human flatus. This toxic gas also has been implicated in the pathogenesis of ulcerative colitis. Therefore, a treatment that reduces colonic H2S levels could be clinically useful in the treatment of flatus odor and of ulcerative colitis. In t...

journal_title：Gastroenterology

authors： Suarez FL,Furne JK,Springfield J,Levitt MD

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND & AIMS:High-level coffee consumption has been associated with reduced progression of pre-existing liver diseases and lower risk of hepatocellular carcinoma. However, its relationship with therapy for hepatitis C virus infection has not been evaluated. METHODS:Patients (n=885) from the lead-in phase of the H...

journal_title：Gastroenterology

authors： Freedman ND,Curto TM,Lindsay KL,Wright EC,Sinha R,Everhart JE,HALT-C TRIAL GROUP.

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND & AIMS:Paneth cells (PCs) secrete defensins and antimicrobial enzymes that contribute to innate immunity against pathogen infections within the mucosa of the small intestine. We examined the role of colony stimulating factor-1 (CSF-1) in PC development. METHODS:CSF-1-deficient and CSF-1 receptor (CSF-1R)-de...

journal_title：Gastroenterology

authors： Huynh D,Dai XM,Nandi S,Lightowler S,Trivett M,Chan CK,Bertoncello I,Ramsay RG,Stanley ER

更新日期：2009-07-01 00:00:00

abstract：:The appropriate treatment of patients with fistulas in the setting of Crohn's disease requires a knowledge of the specific medical and surgical literature of fistulizing Crohn's. The patient with symptomatic fistulizing Crohn's disease may respond differently to specific medical therapy than a patient with symptomatic...

journal_title：Gastroenterology

authors： Lichtenstein GR

更新日期：2000-10-01 00:00:00

abstract：:Effects of opiates on intestinal motor activity and transport of water and electrolytes have been studied separately in previous investigations. The aim of these experiments was to evaluate simultaneously the effects of a synthetic opiate, loperamide, on motor activity and transport in the human intestine. Jejunal, il...

journal_title：Gastroenterology

authors： Kachel G,Ruppin H,Hagel J,Barina W,Meinhardt M,Domschke W

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND & AIMS:To define signaling events initiating healing after intestinal epithelial injury, activation of mitogen-activated protein kinase (MAPK) pathways was assessed after wounding using an in vitro model. METHODS:Proteins isolated from wounded monolayers of nontransformed intestinal epithelial cells (IEC-6)...

journal_title：Gastroenterology

authors： Göke M,Kanai M,Lynch-Devaney K,Podolsky DK

更新日期：1998-04-01 00:00:00

abstract：:We have prospectively studied changes in serum postprandial cholylglycine (CG) concentration during 297 pregnancies. We found an increase in CG concentration from 0.3 mumol/L at 15 weeks' pregnancy to 0.6 mumol/L at 40 weeks' pregnancy. Although this increase was statistically significant (p less than 0.005), median c...

journal_title：Gastroenterology

authors： Lunzer M,Barnes P,Byth K,O'Halloran M

更新日期：1986-10-01 00:00:00

abstract：BACKGROUND & AIMS:Manganese (Mn) deposition could be responsible for the T(1)-weighted magnetic resonance signal hyperintensities observed in cirrhotic patients. These experiments were designed to assess the regional specificity of the Mn increases as well as their relationship to portal-systemic shunting or hepatobili...

journal_title：Gastroenterology

authors： Rose C,Butterworth RF,Zayed J,Normandin L,Todd K,Michalak A,Spahr L,Huet PM,Pomier-Layrargues G

更新日期：1999-09-01 00:00:00

abstract：:Canine jejunal epithelial cells were isolated and maintained in short-term culture to study cholecystokinin (CCK) release. Sequential digestion of jejunal mucosa with collagenase and ethylenediaminetetraacetic acid was followed by counterflow elutriation to enrich CCK-containing cells. After 40 hours in culture on col...

journal_title：Gastroenterology

authors： Koop I,Buchan AM

更新日期：1992-01-01 00:00:00

abstract：:A case is presented of a 76-yr-old woman with primary biliary cirrhosis and adult polycystic liver disease who developed bone marrow toxicity associated with chronic low-dose colchicine therapy. Two months after starting colchicine therapy (0.6 mg b.i.d. p.o.), the patient developed hematologic toxicity as evidenced b...

journal_title：Gastroenterology

authors： Finklestein M,Goldman L,Grace ND,Foley M,Randall N

更新日期：1987-12-01 00:00:00