Abstract:
:Tuberculosis continues to be a major infectious cause of global morbidity and mortality, both in children and adults, in spite of widespread vaccination of infants with Bacille Calmette-Guerin (BCG) and the availability of effective antibiotics. The failure of BCG to significantly affect disease incidence in adults in many endemic countries, combined with the growing HIV epidemic and the appearance of multidrug resistant strains of Mycobacterium tuberculosis, threatens to overwhelm current tuberculosis control strategies. This unfortunate state of affairs has driven an intensive search for better tuberculosis vaccines. This article reviews the various vaccine development strategies which are being used e.g., purification or synthesis of protein peptide and non-peptide antigens from M. tuberculosis, creation of rationally-attenuated mutants of BCG and M. tuberculosis, development of DNA vaccines based upon the published genome sequence, the cloning of mycobacterial genes into living vaccine carrier strains (e.g., attenuated Salmonella, vaccinia virus, etc), or the use of naturally attenuated mycobacterial species (e.g., M. vaccae, M. microti). The animal models in which these vaccine candidates are being screened for protective efficacy (e.g., the mouse, guinea pig, rabbit, primate) will be discussed briefly. Finally, some of the challenges inherent in the eventual clinical evaluation of new tuberculosis vaccines are reviewed.
journal_name
Indian J Pediatrjournal_title
Indian journal of pediatricsauthors
McMurray DNkeywords:
subject
Has Abstractpub_date
2000-02-01 00:00:00pages
S58-62issue
2 Suppleissn
0019-5456issn
0973-7693journal_volume
67pub_type
杂志文章,评审abstract:OBJECTIVE:To assess the need and feasibility of a Transition Clinic in the care of adolescents with chronic illness. METHODS:A qualitative study, piloted by a questionnaire-based survey, followed by Focus Group Discussions was conducted in the Department of Pediatrics in a government teaching hospital in Kerala. The p...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-020-03189-z
更新日期:2020-06-01 00:00:00
abstract::Harlequin fetus is the severe form of congenital ichthyosis. There are very few reports of babies with this condition surviving the first few weeks of life. We treated two siblings who lived for 22 months and six weeks respectively. We started treatment with oral etretinate every early in their lives and achieved good...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02752311
更新日期:1998-03-01 00:00:00
abstract:OBJECTIVE:To investigate obesogenic co-causing factors, promoting rise of weight in children, associated to local differences in India. METHODS:Overall 1,680 children, aged 3-11 and balanced by gender, were recruited in school contexts distributed in seven major Indian cities. All children were weighted and measured i...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-014-1550-0
更新日期:2014-09-01 00:00:00
abstract::Megaloblastic anemia (MA), in most instances in developing countries, results from deficiency of vitamin B(12) or folic acid. Over the last two to three decades, incidence of MA seems to be increasing. Of the two micronutrients, folic acid deficiency contributed to MA in a large majority of cases. Now deficiency of B(...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-010-0121-2
更新日期:2010-07-01 00:00:00
abstract::Thirty patients below the age of 15 years (range 8-1/2 to 15 years, mean 11.8 years) have been studied for the severity of rheumatic mitral regurgitation. Moderately severe to severe pulmonary venous hypertension was found in 76.6% and pulmonary arterial hypertension in 60%. Left ventricular volumes could be calculate...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02832994
更新日期:1992-09-01 00:00:00
abstract::Secondary sex characteristics were evaluated in thalassemic children (41, boys and 30 girls), who were on regular transfusion therapy and were above 11 years of age. The results of this study indicate that the development of secondary sex characteristics in thalassemic children is markedly delayed as compared to their...
journal_title:Indian journal of pediatrics
pub_type: 临床试验,杂志文章
doi:10.1007/BF02725511
更新日期:1997-11-01 00:00:00
abstract::The clinical presentation of pseudohypoaldosteronism (PHA) mimics congenital adrenal hyperplasia (CAH). Poor response of the dehydration and electrolyte abnormalities to steroid therapy should make one suspect PHA. The treatment is supportive in the form of salt replacement and sodium resonium. We report a case of PHA...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02758269
更新日期:2006-01-01 00:00:00
abstract::Vaccine Associated Paralytic Poliomyelitis (VAPP), although a known hazard with Oral Polio Vaccine (OPV), has not received adequate attention in India despite increasing use of OPV in repeated rounds of national immunization days. An analysis by National Polio Surveillance Project in 1999 suggested that incidence of V...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02723161
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVE:To estimate the prevalence of culture-confirmed cholera in patients with acute dehydrating diarrhea, at a tertiary care center in north India, during a 6-month period from March to August, 2006. METHODS:We studied 145 children, who presented to the pediatric emergency services of a tertiary care teaching hos...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-010-0009-1
更新日期:2010-01-01 00:00:00
abstract::Allan-Herndon-Dudley Syndrome (AHDS) is a rare X-linked disorder caused by mutation in the gene encoding the monocarboxylate transporter-8. Abnormal transport function is reflected by elevated free T3 and decreased free T4 levels along with clinical features characterized by neurological abnormalities including global...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVE:To measure the economic output/input ratios for the various options of prevention of rheumatic fever/rheumatic heart disease (RF/RHD) and check the viability of primary prevention vis-à-vis secondary and tertiary preventions. METHODS:Cost accounting of the various prevention options was calculated for each v...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-007-0094-y
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVES:To investigate the presence of Y-chromosome sequences and determine their frequency in patients with Turner syndrome. METHODS:The study included 23 patients with Turner syndrome from Brazil, who gave written informed consent for participating in the study. Cytogenetic analyses were performed in peripheral b...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-015-1929-6
更新日期:2016-05-01 00:00:00
abstract::Effective communication with parents is a very important skill for pediatricians especially in a neonatal setup. The authors analyzed non-verbal communication of medical caregivers during counseling sessions. Recorded videos of counseling sessions from the months of March-April 2016 were audited. Counseling episodes w...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-018-2680-6
更新日期:2018-11-01 00:00:00
abstract::During the four years period from 1988 to 1991, 50 pediatric patients were diagnosed to have bacterial meningitis, out of a total number of 9057 pediatric admissions at Qatif Central Hospital, Qatif, Saudi Arabia, and 82% were less than two years of age. The causative organisms were isolated in 27 (54%) patients. The ...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02859407
更新日期:1992-11-01 00:00:00
abstract:OBJECTIVE:To evaluate all steps of pulse polio immunization on special sub national immunization day. METHODS:On a sub-national immunization day (SNID), 120 booths were randomly selected from 662 booths by probability proportionate to size (PPS) sampling technique. RESULTS:It was observed that attendance in the distr...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-009-0025-1
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:To find out the efficacy of continuous fetal heart monitoring by analyzing the cases of cesarean section for nonreassuring fetal heart in labor, detected by cardiotocography (CTG) and correlating these cases with perinatal outcome. To evaluate whether a 30 minute decision to delivery (D-D) interval for emerge...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-008-0245-9
更新日期:2008-12-01 00:00:00
abstract::The idea that nutrition in early life (such as before conception, during pregnancy and in infancy) can influence, or programme, long-term health, known as the 'Developmental Origins of Health and Disease Hypothesis', has generated great scientific interest. This concept is particularly relevant for the development of ...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-017-2554-3
更新日期:2018-06-01 00:00:00
abstract::A confirmed case of cholera in a 3-day-old neonate is being reported. Possible source of infection could be by holy water (Chamamrit) given to the baby, which is common ritual in India. Mother's milk has never been reported to transmit cholera, even though mother herself may be suffering from cholera. Contaminated wat...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02752426
更新日期:2001-08-01 00:00:00
abstract::Airway malformations such as laryngeal atresia, tracheal agenesis and subglottic stenosis are rare and present at birth with significant respiratory distress with or without stridor. There may be an initial improvement on bag and mask ventilation. Repeated attempts at intubation are met with failure. The related embry...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02726024
更新日期:2002-11-01 00:00:00
abstract::Nosocomial infections in Pediatric Intensive Care Units (PICUs) caused by multidrug-resistant bacterial organisms are increasing. This review attempts to report on significant findings in the current literature related to nosocomial infections in PICU settings with an international perspective. The types of nosocomial...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-010-0253-4
更新日期:2011-02-01 00:00:00
abstract::Death is a natural process, but the definition of death varies depending on the cultural and religious background, all over the world. The historical development of the concept and the current criteria in the determination of brain death must be well understood. Termination of life support measures in a brain dead chi...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/BF02730887
更新日期:1998-07-01 00:00:00
abstract:OBJECTIVES:To determine the incidence, pattern, causality, preventability, severity and predictors of adverse drug reactions (ADRs) in pediatric population. METHODS:It was a prospective, observational study that included patients of either sex, of any age treated in the pediatric wards of a tertiary care hospital. Stu...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-015-2002-1
更新日期:2016-05-01 00:00:00
abstract::The improvement in perinatal care has led to increase in survival as well as reduction of morbidity in sick newborns. These babies need to be followed up regularly to assess growth and neurodevelopmental outcome and for early stimulation and rehabilitation. We present a protocol describing the various components of a ...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-008-0075-9
更新日期:2008-05-01 00:00:00
abstract::The packing and composition of ORS has undergone a change since its introduction. In India, some companies are manufacturing smaller pouches (4.2 g) to be dissolved in 200 ml of water. Therefore, out of confusion some prescribers routinely advise the patients to dissolve the standard formulation ORS pouch (21 g) in a ...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-010-0095-0
更新日期:2010-06-01 00:00:00
abstract::In the pediatric patient, computed tomography (CT) scan as an imaging modality for evaluation of the abdomen is to be used judiciously. The use of correct scanning protocols, single phase scanning, scanning only when required are key factors to minimize radiation doses to the child, while providing diagnostic quality....
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-016-2030-5
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:To determine the utility of CSF Xpert MTB/RIF (GeneXpert) in diagnosis of tubercular meningitis in children in the age group of 2 mo to 12 y. METHODS:This hospital based prospective observational study was conducted at Department of Pediatrics, Karnataka Institute of Medical Sciences (KIMS), Hubli from Decem...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-019-03032-0
更新日期:2019-12-01 00:00:00
abstract::Recurrent Guillain-Barre Syndrome is a rare condition. IVIg and plasmapheresis are costly therapies and may not be affordable. We report a 6-yr-old boy in whom two severe episodes of Guillain-Barre Syndrome were successfully treated by exchange transfusion. Possible explanation for its effectiveness is discussed with ...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-007-0122-y
更新日期:2007-07-01 00:00:00
abstract::Pneumomediastinum and subcutaneous emphysema are rare complications of miliary tuberculosis in children. In this report, a 5-year-old girl with miliary tuberculosis complicated by pneumomediastinum and subcutaneous emphysema, is presented and relevant literature is discussed. ...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02724303
更新日期:2004-06-01 00:00:00
abstract::Forty children aged 5 months to 3 years and suffering from wheezy baby syndrome (WBS) were evaluated to find out the prevalence of neonatal meconium aspiration syndrome (MAS) from the birth records. Twelve (30%) babies with WBS were detected to have a history of MAS at birth, significant enough to require a neonatal I...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02750935
更新日期:1991-07-01 00:00:00
abstract::Lifetime achievement awards are awarded to recognize contributions during the career of an individual, rather than for a single or multiple contributions of a person in his/her field of specialty. I am highly honored being the recipient of the Dr. K. C. Chaudhuri Lifetime Achiement Award Oration. The award for me is s...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-015-1838-8
更新日期:2015-12-01 00:00:00