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Age and other risk factors for neuropsychologic decline in patients undergoing coronary artery bypass graft surgery.

Abstract：

OBJECTIVE:To evaluate if increasing age is a major determinant of long-term neuropsychologic (NP) dysfunction in patients undergoing coronary artery bypass graft (CABG) surgery. DESIGN:Prospective cohort study. SETTING:A single university hospital. PARTICIPANTS:Three hundred eighty-one patients undergoing elective CABG surgery. INTERVENTIONS:Baseline preoperative and intraoperative characteristics were assessed for all patients. A comprehensive NP test battery was conducted preoperatively and at 1 month postoperatively. MEASUREMENTS AND MAIN RESULTS:Of the initial 381 patients, 319 (84%) returned for the 1-month visit. The overall incidence of an NP deficit was 21.6%. There was no significant difference seen with increasing age, although a trend was observed with highest NP deficit rate in the older than 65 age group. Other preoperative risk factors, including gender, education level, and preexisting diseases, were nonsignificant. Intraoperative variables were evaluated and revealed no significant differences across the age groups. CONCLUSIONS:This cohort study did not find an increased incidence of NP deficits in elderly patients after CABG surgery. It has addressed the limitations of other studies, however, with (1) a comprehensive NP test battery, (2) longer-term follow-up, and (3) adequate sample size.

journal_name

J Cardiothorac Vasc Anesth

journal_title

Journal of cardiothoracic and vascular anesthesia

authors

Smith MH,Wagenknecht LE,Legault C,Goff DC,Stump DA,Troost BT,Rogers AT

doi

10.1053/jcan.2000.7941

keywords:

subject

Has Abstract

pub_date

2000-08-01 00:00:00

pages

428-32

issue

4

eissn

1053-0770

issn

1532-8422

pii

S1053-0770(00)10793-1

journal_volume

14

pub_type

杂志文章

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