Abstract：
:Surface active material is important in the function of both the infant and adult lung. In the premature infant, surfactant depletion results in the requirement for very high distending pressures to open alveoli. As a consequence, shunt, hypoxemia, and right ventricular dysfunction occur. Surfactant replacement, especially by the direct instillation approach, has been proven effective in improving clinical outcome under these circumstances. Problems with surfactant instillation include the "fluid bolus" effect and concerns about optimal distribution of the instilled material. Recent improvements in aerosol systems have created interest in using aerosol delivery to reduce the total dose of surfactant required to treat RDS. In adult acute lung injury, surfactant dysfunction, rather than depletion, is the problem. Simple phospholipid replacement strategies thus may not be effective. Instead, surfactant delivery strategies aimed at regional targeting with surfactants having the necessary associated proteins may be the goal in ARDS. In adults, several instillation trials are underway, but there is also a hope that an aerosol strategy might also be tried. The aerosol route may be particularly useful if a high-efficiency aerosol system (eg, one distal to an endotracheal tube) can be shown to be effective. Other surface active materials exist and there are small studies showing benefit when large instilled doses of these materials are given. These materials, however, have never been studied as aerosols.
journal_name
Respir Carejournal_title
Respiratory careauthors
MacIntyre NRkeywords:
subject
Has Abstractpub_date
2000-06-01 00:00:00pages
676-83issue
6eissn
0020-1324issn
1943-3654journal_volume
45pub_type
杂志文章,评审相关文献
Respiratory Care文献大全abstract：BACKGROUND:The nasopharyngeal tube (NT) is a potential interface for noninvasive ventilation (NIV) available in all health care centers. The aim of the study was to describe our experience in the use of the NT for bi-level NIV in infants and its effectiveness. METHODS:Prospective observational study from January 2007 ...
journal_title：Respiratory care
pub_type： 杂志文章
doi：10.4187/respcare.02556
更新日期：2014-04-01 00:00:00
abstract：:In blood gas laboratory quality-assurance programs, which are routinely included with materials sold for quality control, raw data are sent to a data processing center for reduction to statistics meaningful to the laboratory's quality-control effort. This data reduction service usually requires a turn-around time of 2...
journal_title：Respiratory care
pub_type： 杂志文章
doi：
更新日期：1984-04-01 00:00:00
abstract：BACKGROUND:The ability to rapidly and precisely evaluate patients in respiratory distress is essential. Due to limited opportunities for formal instruction during training, textbooks are the main educational source to teach junior physicians how to interpret the signs of respiratory distress. The quality of the textbo...
journal_title：Respiratory care
pub_type： 杂志文章
doi：10.4187/respcare.01112
更新日期：2012-03-01 00:00:00
abstract：BACKGROUND:In patients suffering from brain injury, end-tidal PCO2 (PETCO2 ) monitoring is controversial, but transcutaneous PCO2 (PtcCO2 ), which is noninvasive and utilizes immediate display, may be an alternative method. We hypothesized that PtcCO2 would be more accurate than PETCO2 for monitoring PaCO2 in patients ...
journal_title：Respiratory care
pub_type： 杂志文章
doi：10.4187/respcare.02726
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:The prevalence of sleep-disordered breathing (SDB) in patients with prolonged mechanical ventilation (PMV) is unknown. The aim of this study was to assess the frequency of SDB in patients admitted to a long-term acute care (LTAC) hospital who weaned from PMV. METHODS:Retrospective chart review was conducte...
journal_title：Respiratory care
pub_type： 杂志文章
doi：10.4187/respcare.01260
更新日期：2012-02-01 00:00:00
abstract：BACKGROUND:Endotracheal intubation is a common procedure performed by respiratory therapists (RTs). The purpose of this study was to describe current RT intubation practices in North Carolina through the use of a survey instrument. METHODS:A survey was developed by the authors using REDCap. The survey was sent via ema...
journal_title：Respiratory care
pub_type： 杂志文章
doi：10.4187/respcare.07338
更新日期：2020-07-01 00:00:00
abstract：:In health, the airways are lined by a layer of protective mucus gel that sits atop a watery periciliary fluid. Mucus is an adhesive, viscoelastic gel, the biophysical properties of which are largely determined by entanglements of long polymeric gel-forming mucins, MUC5AC and MUC5B. This layer entraps and clears bacter...
journal_title：Respiratory care
pub_type： 杂志文章
doi：
更新日期：2007-07-01 00:00:00
abstract：INTRODUCTION:Common modalities of clinical exercise testing for outcome measurement after pulmonary rehabilitation (PR) include walk tests, progressive cycle ergometry, and cycle endurance testing. We hypothesized that patients' responses to PR, as measured by those 3 tests, are differentially correlated, and we design...
journal_title：Respiratory care
pub_type： 杂志文章
doi：
更新日期：2004-12-01 00:00:00
abstract：BACKGROUND:Pneumoperitoneum and Trendelenburg position affect respiratory system mechanics and oxygenation during elective pelvic robotic surgery. The primary aim of this randomized pilot study was to compare the effects of a conventional low tidal volume ventilation with PEEP guided by gas exchange (VGas-guided) versu...
journal_title：Respiratory care
pub_type： 杂志文章,随机对照试验
doi：10.4187/respcare.07238
更新日期：2020-05-01 00:00:00
abstract：:Several algorithms exist to facilitate spirometric interpretation in clinical practice, yet there is a lack of consensus on how spirometric criteria for asthma, COPD, and restrictive disorders should be incorporated into spirometry interpretation algorithms suitable for use in day-to-day primary care management. The p...
journal_title：Respiratory care
pub_type： 杂志文章
doi：10.4187/respcare.07294
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:The benefits of contract learning have been identified in the literature as increased individualization to meet the student's individual needs, promotion of learner independence, and development of lifelong learning behaviors among students. METHODS:I used an "action research" approach to implement the cont...
journal_title：Respiratory care
pub_type： 杂志文章
doi：
更新日期：2008-11-01 00:00:00
abstract：:Delivering long-term oxygen therapy in the homes of persons who live in remote areas can be a problem. Four isolated areas in North America--rural Manitoba, Canada; the Northwest Territories of Canada; Alaska; and the Colorado mountains--have home oxygen programs that illustrate that these problems can be overcome. Th...
journal_title：Respiratory care
pub_type： 杂志文章
doi：
更新日期：1983-07-01 00:00:00
abstract：:Explaining the meaning of the results to the reader is the purpose of the discussion section of a research paper. There are elements of the discussion that should be included and other things that should be avoided. Always write the discussion for the reader; remember that the focus should be to help the reader unders...
journal_title：Respiratory care
pub_type： 杂志文章
doi：
更新日期：2004-10-01 00:00:00
abstract：BACKGROUND:Health-care providers often diagnose and empirically treat COPD without a confirmative pulmonary function test (PFT) or even despite a PFT that is not diagnostic of obstructive lung disease. We hypothesized that a portion of patients continue to carry a persistent empiric COPD diagnosis and receive treatment...
journal_title：Respiratory care
pub_type： 杂志文章
doi：10.4187/respcare.04647
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:Electrical impedance tomography measures changes in lung impedance, which are mainly related to changes in lung volume. We used electrical impedance tomography to investigate the effects of high-flow nasal cannula (HFNC) and body position on global and regional end-expiratory lung impedance variation (ΔEELI)...
journal_title：Respiratory care
pub_type： 杂志文章
doi：10.4187/respcare.02086
更新日期：2013-04-01 00:00:00
abstract：:Mechanically ventilated patients in respiratory failure often require adjunct therapies to address special needs such as inhaled drug delivery to alleviate airway obstruction, treat pulmonary infection, or stabilize gas exchange, or therapies that enhance pulmonary hygiene. These therapies generally are supportive in ...
journal_title：Respiratory care
pub_type： 杂志文章,评审
doi：10.4187/respcare.02217
更新日期：2013-06-01 00:00:00
abstract：:Chronic obstructive pulmonary disease is easily detected in its preclinical phase, using office spirometry. Successful smoking cessation prevents further disease progression in most patients. Spirometry measures the ratio of the forced expiratory volume in the first second to the forced vital capacity (FEV(1)/FVC), wh...
journal_title：Respiratory care
pub_type： 杂志文章,评审
doi：
更新日期：2003-12-01 00:00:00
abstract：:End-stage liver disease and its complications are a leading cause of death among adults in the United States, and thousands of patients await liver transplantation. The liver plays a central role in health and homeostasis and thus the diseased liver leads to many deleterious effects on multiple organ systems, includin...
journal_title：Respiratory care
pub_type： 杂志文章,评审
doi：
更新日期：2007-08-01 00:00:00
abstract：BACKGROUND:In a traditional endotracheal tube (ETT), there is a linear outward pull through its attachment to the ventilator tubing that leads to risk of accidental dislodgement. This study was conducted to assess the ETT flow characteristics and to evaluate providers' intubation experience using two ETT's in a simulat...
journal_title：Respiratory care
pub_type： 杂志文章
doi：10.4187/respcare.05813
更新日期：2018-09-01 00:00:00
abstract：BACKGROUND:Gas exchange measurements for carbon dioxide elimination (V̇CO2 ) and oxygen consumption (V̇O2 ) have been used to derive resting energy expenditure and guide energy prescription. Volumetric capnography is used in intensive care units and provides V̇CO2 measurements that could be used for titrating respirato...
journal_title：Respiratory care
pub_type： 杂志文章
doi：10.4187/respcare.04282
更新日期：2016-03-01 00:00:00
abstract：:We describe the combined use of inhaled nitric oxide and heliox (79% helium and 21% oxygen) as a rescue therapy for a critically ill infant with localized interstitial pulmonary emphysema and pulmonary hypertension. Conventional interventions were ineffective, not feasible, or unlikely to take effect in time, during t...
journal_title：Respiratory care
pub_type： 杂志文章
doi：
更新日期：2008-12-01 00:00:00
abstract：:Although oral and injectable drug formulations still dominate the market, interest in pulmonary delivery has been rising steadily. Given patients' desire for an alternative to injections, and recent advances in aerosol science and pulmonary medicine, the potential for improved disease management outcomes by using aero...
journal_title：Respiratory care
pub_type： 杂志文章,评审
doi：
更新日期：2000-07-01 00:00:00
abstract：:Surveys are a valuable research tool for studying the knowledge, attitudes, and behavior of a study population. This article explores quantitative analyses of written questionnaires as instruments for survey research. Obtaining accurate and precise information from a survey requires minimizing the possibility of bias ...
journal_title：Respiratory care
pub_type： 杂志文章
doi：
更新日期：2004-10-01 00:00:00
abstract：BACKGROUND:Esophageal balloon inflation volume may affect the accuracy of transpulmo-nary pressure estimates in adults, but the effect is unknown in pediatrics. Using a combination bench and human study, we sought to determine a range of optimal filling volumes for esophageal balloon catheters and to derive a technique...
journal_title：Respiratory care
pub_type： 杂志文章
doi：10.4187/respcare.05685
更新日期：2018-02-01 00:00:00
abstract：:Gorham syndrome is a rare disease that presents as progressive osteolysis, and may affect any part of the skeleton. The pathologic process involves the replacement of normal bone by aggressively expanding but non-neoplastic vascular tissue, resulting in massive osteolysis of the adjacent bone. If the spine and ribs ar...
journal_title：Respiratory care
pub_type： 杂志文章
doi：10.4187/respcare.02355
更新日期：2013-11-01 00:00:00
abstract：:Acute brain injury, in the form of trauma, stroke, or spontaneous hemorrhage, occurs commonly and in all age groups. Although the management of these conditions differs considerably, certain physiologic principles are shared by all and are useful in guiding the management of the most severely injured patients. This ar...
journal_title：Respiratory care
pub_type： 杂志文章
doi：
更新日期：2006-04-01 00:00:00
abstract：:The treatment of choice for patients with respiratory failure of neuromuscular origin, especially in patients with hypercapnic respiratory acidosis, is noninvasive ventilation (NIV). Endotracheal intubation and invasive ventilation are indicated for patients with severe respiratory compromise or failure of NIV. In rec...
journal_title：Respiratory care
pub_type： 杂志文章
doi：10.4187/respcare.02115
更新日期：2013-12-01 00:00:00
abstract：:Patient adherence with prescribed inhaled therapy is related to morbidity and mortality. The terms "compliance" and "adherence" are used in the literature to describe agreement between prescribed medication and patient practice, with "adherence" implying active patient participation. Patient adherence with inhaled med...
journal_title：Respiratory care
pub_type： 杂志文章,评审
doi：
更新日期：2005-10-01 00:00:00
abstract：:CPAP is a spontaneous mode of ventilation that maintains a constant airway pressure during the inspiratory and expiratory phases. This therapeutic modality is used across the continuum of care from pre-hospital treatment to intensive and acute care units to the home care environment to treat a host of acute and chroni...
journal_title：Respiratory care
pub_type： 杂志文章,评审
doi：10.4187/respcare.06625
更新日期：2019-06-01 00:00:00
abstract：BACKGROUND:The addition of heated humidification to CPAP has been shown to improve nasal adverse effects in subjects with obstructive sleep apnea (OSA). However, current data regarding improvement in CPAP adherence is conflicting. Furthermore, there are no data from a tropical climate area with a high humidity level. ...
journal_title：Respiratory care
pub_type： 杂志文章,随机对照试验
doi：10.4187/respcare.04536
更新日期：2016-09-01 00:00:00
