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HDEA, a periplasmic protein that supports acid resistance in pathogenic enteric bacteria.

Abstract：

:The X-ray crystal structure of the Escherichia coli stress response protein HDEA has been determined at 2.0 A resolution. The single domain alpha-helical protein is found in the periplasmic space, where it supports an acid resistance phenotype essential for infectivity of enteric bacterial pathogens, such as Shigella and E. coli. Functional studies demonstrate that HDEA is activated by a dimer-to-monomer transition at acidic pH, leading to suppression of aggregation by acid-denatured proteins. We suggest that HDEA may support chaperone-like functions during the extremely acidic conditions.

journal_name

J Mol Biol

journal_title

Journal of molecular biology

authors

Gajiwala KS,Burley SK

doi

10.1006/jmbi.1999.3347

keywords:

subject

Has Abstract

pub_date

2000-01-21 00:00:00

pages

605-12

issue

3

eissn

0022-2836

issn

1089-8638

pii

S0022-2836(99)93347-8

journal_volume

295

pub_type

杂志文章

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