Prognostic value of peritoneal lavage cytology and chemotherapy during surgery for advanced gastric cancer.

Abstract:

BACKGROUND:The prognostic value of intra-operative peritoneal lavage cytology and chemotherapy was evaluated retrospectively. METHOD:Lavage cytology was performed in 257 patients. Prognosis was investigated in 85 of pT3 and pT4 patients with radical gastrectomy. Intra-operative chemotherapy was selected according to the cytology and exploration of the peritoneal cavity. For patients forecasted to have peritoneal recurrence, intraperitoneal injection of cisplatin was performed. RESULTS:No free cancer cells (cy(-)) were found in pTis, pT1 and pT2. In pT3 and pT4, cy(-) were 82.8% of the cases without macroscopic metastasis (P(-)), and the presence of free cancer cells (cy(+)) were 89.3% of the cases with macroscopic metastasis (P(+)). Intraperitoneal injection was performed in about 60% of P(-)/cy(+) and P(+) cases. Five-year survival rate of P(-)/cy(-) was 41.7% and that of P(-)/cy(+) was 33.3%. All of P(+) died within 3 years. CONCLUSION:Patients of P(-)/cy(+) probably had microscopic residual disease and might benefit from intraperitoneal chemotherapy.

journal_name

Int Surg

journal_title

International surgery

authors

Funami Y,Tokumoto N,Miyauchi H,Ochiai T,Kuga K

keywords:

subject

Has Abstract

pub_date

1999-07-01 00:00:00

pages

220-4

issue

3

eissn

0020-8868

issn

2520-2456

journal_volume

84

pub_type

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