Abstract：
:We aimed to investigate whether tolerogenic dendritic cells (DCs) were induced in the tolerant recipients with the blockade of CD40-CD40L costimulation. Mouse heterotopic heart transplantation was performed. DCs were sorted from rejected and tolerant recipients using magnetic-activated cell sorting. Their expression of CD40, CD80, and CD86 was examined using fluorescence-activated cell sorting. DCs were stimulated with lipopolysaccharide in vitro, and interleukin 10 (IL-10) and IL-12 levels in the supernatants were evaluated using enzyme-linked immunosorbent assay. By using mixed leukocyte reaction, we investigated the stimulatory capacities and tolerogenic capability of DCs. DCs from tolerant recipients expressed lower level of costimulatory molecules, including CD40, CD80, and CD86 and released higher levels of IL-10 and lower levels of IL-12. In addition, DCs from tolerant recipients were weak stimulators of the mixed leukocyte reaction and inhibited the proliferation of splenocytes. IL-10(high)IL-12(low) DCs with immature phenotype were induced in the tolerant recipients with the blockade of CD40-CD40L costimulation, and they obtained the tolerogenic function.
journal_name
Int Surgjournal_title
International surgeryauthors
Jiang XF,Cui ZM,Zhu L,Guo DW,Sun WY,Lin L,Wang XF,Tang YF,Liang Jsubject
Has Abstractpub_date
2010-04-01 00:00:00pages
135-41issue
2eissn
0020-8868issn
2520-2456journal_volume
95pub_type
杂志文章abstract：:Four operative cases of lung cancer with intra-atrial extension via the pulmonary vein were reviewed. Three of them had circulatory as well as respiratory symptoms, and their performance status (PS) was extremely poor. In two cases, after assessment of the cardiac involvement using two-dimensional echocardiography and...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:Splenitis can complicate blood-borne sepsis in hemodialysis patients. Symptoms include left upper quadrant pain and tenderness in addition to generalized systemic manifestation of infection. Clinical diagnosis is difficult and there is no specific investigation to confirm it. Computed tomography scan of the spleen can...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：2002-10-01 00:00:00
abstract：:Of 144 cases of pancreatoduodenectomy we treated 6 patients (4.2%) with delayed massive bleeding. Massive hemorrhage occurred 14 to 38 days later. Leakage of the pancreatojejunostomy was confirmed in all patients. A "sentinel bleed" was evident in five patients with arterial bleeding. One patient with hemorrhage of th...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1998-04-01 00:00:00
abstract：:Three-hundred and forty-five cases of perforated duodenal ulcer were managed by suture plication alone. Perforated acute ulcers have a better ultimate outlook in terms of mortality and morbidity as compared with perforated chronic ulcers, which have a higher incidence of reperforation and reoperation. It is suggested ...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1982-10-01 00:00:00
abstract：BACKGROUND:Extended cholecystectomy is the common operation for gallbladder carcinoma. When extended cholecystectomy is performed, the liver bed can be generously resected from the fundus to the body of the gallbladder; however, the thickness of the liver parenchyma to be removed is limited to the neck of the gallbladd...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:Temporary closure of the abdomen with a synthetic mesh and multiple planned relaparotomies are the essentials of the modern strategy for treating severe intra-abdominal sepsis or pancreatic necrosis. One of the complications associated with mesh closure of the abdomen is facial necrosis at the wound edges leading to e...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:Mechanical trauma, thermal injury, tissue ischemia during the operation, postoperative infections, and foreign body reactions are important factors for adhesion formation. Bleeding and bile leakage after liver resections can also cause intra-abdominal adhesions. We aimed to evaluate the intra-abdominal adhesions after...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：:Obstructive jaundice in patients with chronic pancreatitis still constitutes a surgical problem deserving the attention of many specialized centers throughout the world. Out of a series of 149 patients operated upon for chronic pancreatitis, 45 (30.2%) with common duct stricture secondary to pancreatic disease have be...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1984-04-01 00:00:00
abstract：:A retrospective analysis of 88 ovarian tumours diagnosed over five years (1980-1984) in multi-racial Singaporean Oriental women revealed 70 (79%) epithelial tumours (ET), 17 (8%) sex cordstromal (SCS), six (7%) germ cell (GCT) and five (6%) secondary (metastatic) (SEC) cancers. The racial proportions and histological ...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
abstract：:Preoperative hyperthermo-chemo-radiotherapy (HCR) has been performed on patients with esophageal carcinoma, especially in advanced cases with invasion to the neighbouring structures (a3 carcinoma), and is considered to have contributed to the favorable postoperative prognosis. 163 patients with operated locally advanc...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:This study examined whether subcuticular absorbable sutures actually reduce incisional SSI in patients undergoing surgery for gastrointestinal (GI) cancer. Surgical site infection (SSI) is still a source of major complications in digestive tract surgery. Reportedly, incisional SSI can be reduced using subcuticular sut...
journal_title：International surgery
pub_type： 杂志文章
doi：10.9738/INTSURG-D-14-00185.1
更新日期：2015-06-01 00:00:00
abstract：:A free jejunal autograft reconstruction after debulking high stage larynx and hypopharynx tumors has become a popular method in our 10-year experience. We retrospectively studied the efficacy and outcome. Nine patients (M/F, 8/1) underwent a total of 10 free jejunal autograft reconstructions. The median age was 58.6 y...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：2006-07-01 00:00:00
abstract：:Fifteen patients with 16 histologically verified heterotopic pancreas lesions were encountered at our department during a period of 22 years. The incidence was 0.25% of the findings of all abdominal operations during the same period. Heterotopic pancreas caused symptoms in 5 patients. All the remaining 10 patients wer...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:We have reported one case of a rare combination of multiple primary malignancies in the stomach, a leiomyosarcoma and an adenocarcinoma in a 72-year-old male. He also had a leiomyoma of the stomach and a cavernous hemangioma of the spleen. Since he has had two malignant and two benign tumors, it would appear that this...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1979-03-01 00:00:00
abstract：:Incidence of cholelithiasis in the teaching hospital population of India has been reported. The study suggests that North Indians are more prone to cholelithiasis than South Indians. Apparently this variation is related to dietary and geographical factors. ...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1977-03-01 00:00:00
abstract：:The authors report their experience of the surgical treatment of varicocele. After having performed modified Palomo's method for many years, recent pathogenetic data have induced them to adopt a microsurgical technique. This technique involves vascular anastomoses which allow drainage of the testicular blood into an a...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1989-10-01 00:00:00
abstract：:A case of acute mesenteric ischemia and massive intestinal infarction secondary to bilateral lumbar sympathectomy and without any other apparent precipitating factors is presented. Its characteristics and findings significantly agree with those described as part of the mesenteric arterial steal syndrome. Although this...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1979-05-01 00:00:00
abstract：:Hemobilia is the process of bleeding into the biliary tree and is an unusual cause of upper gastrointestinal hemorrhage. When this event results from a cystic artery pseudoaneurysm, it is a particularly rare phenomenon; fewer than 20 cases are described in the literature. Alongside the literature review, we report a c...
journal_title：International surgery
pub_type： 杂志文章,评审
doi：10.9738/CC52.1
更新日期：2012-04-01 00:00:00
abstract：:The activities of cathepsin B, D and G, and their distribution in the walls of normal aorta and those of aneurysms of abdominal aorta were studied. The immunohistochemical reaction for these cathepsins was positive in the aneurysm wall both in the cells and in the extracellular matrix. It was more apparent than in nor...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1997-10-01 00:00:00
abstract：:The spleen in newborns, infants, and children is rarely involved in a variety of pathological processes. These processes may involve an isolated splenic disease or may be a part of a systemic illness. Renal vein thrombosis in infants of diabetic mothers has been reported. We report a case of a newborn with intestinal ...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：2002-07-01 00:00:00
abstract：:Obesity is an additional risk factor in surgical patients. The mortality rate in obese patients is high (3.6% in my series) and the morbidity is much higher. These patients may be prediabetic, diabetic, hypertensive or atherosclerotic and they are liable to develop postoperative coronary thromboses and chest complicat...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1985-04-01 00:00:00
abstract：:Cases with concurrent pheochromocytoma and renal artery stenosis, two "surgically curable" hypertensive disorders, are rare. The stenosis is generally secondary to direct compression or stretching of the renal artery by the tumor. Five such cases are reported. Sometimes the tumor and the renal artery stenosis occur in...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1985-04-01 00:00:00
abstract：:In a group of 82 women with congenital or acquired uterine malformation (such as intrauterine adhesions or uterus myomatosus), cerclage was successfully performed according to the McDonald method. The percentage of term deliveries increased from 29.8% to 69.2% and the percentage of spontaneous abortions decreased from...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1977-04-01 00:00:00
abstract：:A 68-year-old man underwent pancreaticoduodenectomy with lymph nodes dissection for carcinoma of the ampulla of Vater. The patient had anxiety neurosis and had been treated with a selective serotonin reuptake inhibitor (SSRI). Postoperatively, SSRI was resumed on postoperative day 2. His serum sodium concentration gra...
journal_title：International surgery
pub_type： 杂志文章
doi：10.9738/INTSURG-D-13-00032.1
更新日期：2013-10-01 00:00:00
abstract：:The diagnostic and therapeutic problems involved in 29 cases of isolated hepatic tumors have been presented. In nine cases the hepatoma was discovered during emergency treatment for complications. Selective arteriography was the most accurate method of establishing the etiologic diagnosis. Suprahepatic phlebography in...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1976-08-01 00:00:00
abstract：:For a variety of reasons, mainly anatomical, the skin and soft tissue defects in the lower leg and foot remain a challenging problem for reconstructive surgeons. Simple skin grafts, local random flaps, cross leg flaps, microvascular flaps, etc., have been used to tackle this difficult problem. Although to date, probab...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：2001-07-01 00:00:00
abstract：:Many patients die each year lacking only a functional small bowel to survive. The minimum amount of small intestinal absorptive surface required to sustain life varies from patient to patient. Prolonged survival with oral alimentation alone has been reported in a few patients with an intact duodenum and as little as 1...
journal_title：International surgery
pub_type： 杂志文章,评审
doi：
更新日期：1999-10-01 00:00:00
abstract：:A proper preoperative staging of rectal tumors is important for correct treatment planning. We included in our study 23 patients with rectal carcinoma in order to evaluate the diagnostic accuracy of endorectal MRI. This technique enabled us to show neoplasms as a hyperintense lesion as compared to the muscolaris. To b...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1996-10-01 00:00:00
abstract：:We made clinical trials of en bloc extended radical mastectomy (EXT) of a new type in 118 patients from 1980 through 1985. A variety of conventional radical mastectomies (RDL) were also performed in 105 patients from 1973 through 1985. A multivariate analysis was performed of the results to compare EXT and RDL. The re...
journal_title：International surgery
pub_type： 临床试验,杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Transesophageal echocardiography (TEE) has been established as a very valuable asset for patient monitoring during cardiac surgery. The value of perioperative TEE for patients undergoing noncardiac surgery is less clear. This article reviews the technical aspects of TEE and comments on the potential benefit of using T...
journal_title：International surgery
pub_type： 杂志文章,评审
doi：10.9738/CC61.1
更新日期：2012-01-01 00:00:00
