Abstract:
PURPOSE:This study aimed to assess the effect of intraoperative PEEP intervention on the healing of colonic anastomoses in rabbits. MATERIALS AND METHODS:Thirty-two New Zealand type male rabbits were divided into two groups of sixteen animals each. Following ventilation with tracheostomy, colonic resection and anastomosis were performed in both groups. While 10 cm H2O PEEP level was applied in Group I (PEEP), Group II (ZEEP) was ventilated without PEEP throughout the surgery. Half of the both PEEP and ZEEP group animals were killed on the third postoperative day, while the remaining half on the seventh. Anastomotic bursting pressures, the tissue concentrations in hydroxyproline, and histological assessments were performed. Besides, intraoperative oxygen saturation and postoperative arterial blood gas parameters were also compared. RESULTS:On the first postoperative day, both arterial oxygen tension (PO2) and oxygen saturation (SO2) in the PEEP group were significantly higher than in the ZEEP group. On the seventh postoperative day, the bursting pressures of the anastomoses were significantly higher in the PEEP group, however the hydroxyproline content was significantly lower in the PEEP group than that in the ZEEP group. At day 7, PEEP group was significantly associated with increased neoangiogenesis compared with the ZEEP group. CONCLUSION:The anastomotic healing process is positively influenced by the intraoperative PEEP application.
journal_name
Int Surgjournal_title
International surgeryauthors
Turkoglu M,Bostancı EB,Bilgili H,Türkoğlu Y,Karadeniz Ü,Aydoğ G,Erçin U,Bilgihan A,Özer İ,Akoğlu Mdoi
10.9738/INTSURG-D-15-00160.1subject
Has Abstractpub_date
2015-07-27 00:00:00eissn
0020-8868issn
2520-2456pub_type
杂志文章abstract::The purpose of this study was to clarify the rate and characteristics of conscious disorder without intracranial hemorrhagic injury in polytrauma patients. The medical records of polytrauma patients with conscious disorder without intracranial hemorrhagic injury were reviewed. Fifty-five patients (35.3% of 156 polytra...
journal_title:International surgery
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abstract::NO is an important mediator in the generalized inflammatory response of the body during sepsis and septic shock. We investigated the possible effects of L-arginine and aminoguanidine on plasma NO levels and the interaction between NO levels and lung tissue damage and blood gases in sepsis. Fifty Wistar male rats were ...
journal_title:International surgery
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pub_type: 杂志文章
doi:
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doi:
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doi:
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doi:
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doi:
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pub_type: 杂志文章
doi:
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doi:
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doi:
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journal_title:International surgery
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
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