Abstract:
AIMS:To assess the possible role of hypoxia in the formation of axonal bulbs. METHODS:Study material comprised sections from 28 brains showing evidence of cerebral hypoxia with no history of head injury, four with a history of head trauma but no evidence of hypoxic change, eight with a history of head trauma and hypoxic change, and four from control brains originally described as "diffuse axonal injury." These were subjected to microwave antigen retrieval and immunohistochemistry using monoclonal antibodies to beta amyloid precursor protein (beta APP), glial fibrillary acid protein (GFAP), and CD68-PGM1. RESULTS:Positive staining for beta APP was seen in all four controls, all four cases of head injury only, seven of eight cases of head injury and hypoxic changes, and 12 of 28 cases of hypoxia without history of head injury; 22 of 25 cases who had been ventilated showed positive staining. The majority of cases showed evidence of cerebral swelling. CONCLUSIONS:Axonal bulbs staining positively for beta APP may occur in the presence of hypoxia and in the absence of head injury. The role of hypoxia, raised intracranial pressure, oedema, shift effects, and ventilatory support in the formation of axonal bulbs is discussed. The presence of axonal bulbs cannot necessarily be attributed to shearing forces alone.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Kaur B,Rutty GN,Timperley WRdoi
10.1136/jcp.52.3.203keywords:
subject
Has Abstractpub_date
1999-03-01 00:00:00pages
203-9issue
3eissn
0021-9746issn
1472-4146journal_volume
52pub_type
杂志文章abstract::Experiments are described with glass fibre filter paper and complete glass filters as fitted to high pre-vacuum autoclaves to determine whether organisms can grow or penetrate through the filters. A filter consisting of four layers of glass fibre paper fitted inside a sterilizer chamber for a year and used for 96 ster...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.16.3.259
更新日期:1963-05-01 00:00:00
abstract:AIMS/BACKGROUND:A major medical role for postmortem examinations is the detection of clinically unexpected disease processes contributing to death. The aim of the present study was to determine whether simple clinical parameters can predict the presence of important unanticipated findings at necropsy. METHODS:Prospect...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.49.11.909
更新日期:1996-11-01 00:00:00
abstract::Pseudomonas cepacia (Ps. multivorans) can become adapted to a 1 in 30 dilution of Savlon hospital concentrate in distilled water, and can multiply in it. The organism so adapted did not survive in Savlon of the same strength made with hard tap water (pH 7.2). This effect was due to the difference of pH between the two...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.24.8.708
更新日期:1971-11-01 00:00:00
abstract::Superficial inflammatory dermatoses are very common and comprise a wide, complex variety of clinical conditions. Accurate histological diagnosis, although it can sometimes be difficult to establish, is essential for clinical management. Knowledge of the microanatomy of the skin is important to recognise the variable h...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jcp.2005.027151
更新日期:2005-12-01 00:00:00
abstract::A correlative clinical and Hemalog D study of 80 cases of chronic lymphocytic leukaemia (CLL) was performed and the results compared with those in other lymphoproliferative disorders affecting the blood (eight cases of hairy-cell leukaemia, HCL; three cases of prolymphocytic leukaemia, PLL: two cases of lymphoplasmacy...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.34.5.473
更新日期:1981-05-01 00:00:00
abstract::With lymph node enlargement, the possibility of a malignant process such as metastatic carcinoma or lymphoma needs to be excluded. This report describes a 47 year old woman with inguinal lymph node enlargement initially suspicious for lymphoma. Fine needle aspiration findings favoured reactive hyperplasia, but a malig...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.53.7.549
更新日期:2000-07-01 00:00:00
abstract::Advanced non-small cell lung cancer samples are tested for epidermal growth factor receptor (EGFR) gene mutations. Their detection by direct sequencing is time-consuming. Conversely, the length analysis of fluorescently labelled PCR products is easier. To avoid labelled primers and the automated capillary electrophore...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2013-201730
更新日期:2013-11-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2006.038901
更新日期:2007-04-01 00:00:00
abstract:AIMS:To test whether a hypoacidic environment may potentially "stress" Helicobacter pylori DNA, encouraging the emergence of strain variation. METHODS:This hypothesis was tested by inducing prolonged hypoacidity with omeprazole, a potent antisecretory drug. The genomic DNA of H pylori was studied by electrophoretic se...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.45.12.1062
更新日期:1992-12-01 00:00:00
abstract::The possible use of sodium hypochlorite solution buffered to pH 7.6 and containing 100 ppm available chlorine (avCl) for disinfecting fibrescopes was investigated. A flexible fibrescope experimentally contaminated with Pseudomonas putida, Mycobacterium fortuitum, or Bacillus subtilis spores was effectively disinfected...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.35.3.296
更新日期:1982-03-01 00:00:00
abstract::An elution technique is described which gives eluates at least as potent as previously described methods. Elution can be completed in only 15 minutes. The method, a modification of that of Vos and Kelsall, is simple to carry out and requires the minimum of equipment. Studies have shown that the coating antibody is alm...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.16.1.70
更新日期:1963-01-01 00:00:00
abstract:BACKGROUND:Cardiac remodelling after acute myocardial infarction (AMI) is characterised by molecular and cellular mechanisms involving both left and right ventricles, and biventricular failure identifies patients with an extremely unfavourable prognosis. AIMS:To assess whether a link exists between increased myocardia...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.56.9.672
更新日期:2003-09-01 00:00:00
abstract::Eosinophil polymorphonuclear leucocytes (polymorphs) were counted in 45 specimens from patients with Hodgkin's disease and five specimens from patients with reactive follicular hyperplasia. The use of chlorazol fast pink BK, a little known stain for eosinophil polymorphs, combined with image analysis facilitated rapid...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.37.3.267
更新日期:1984-03-01 00:00:00
abstract:BACKGROUND/AIMS:Lymphocytic colitis is a clinicopathological entity characterised by protracted watery diarrhoea and an increased number of intraepithelial lymphocytes (IELs) in the surface epithelium of the colonic mucosa. This report describes two patients with symptoms similar to those of lymphocytic colitis and an ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.55.2.138
更新日期:2002-02-01 00:00:00
abstract::Serial dilutions of Clostridium difficile culture filtrates were incubated overnight with HeLa cell monolayers. Cells were fixed in formalin, stained with crystal violet, rinsed, and drained. Cell rounding could be observed microscopically in the stained monolayers. Absorbance of the retained dye on monolayers in the ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.39.6.672
更新日期:1986-06-01 00:00:00
abstract::A case of chronic neutrophilic leukaemia (CNL) is reported. The diagnosis was based on leucocytosis with mature neutrophils, a raised leucocyte alkaline phosphatase score, negative Philadelphia chromosome, and extensive infiltration of neutrophils in various differentiation stages into the bone marrow. When viewed by ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.47.4.367
更新日期:1994-04-01 00:00:00
abstract:OBJECTIVES:To evaluate the protein expression of connexin 43 (Cx43) in primary urothelial bladder cancer and test its association with the histopathological characteristics and clinical outcome. METHODS:A tissue microarray containing 348 tissue samples from 174 patients with primary urothelial carcinomas of the bladde...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2015-202898
更新日期:2015-10-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2013-201978
更新日期:2014-07-01 00:00:00
abstract::A case of cirrhosis of the liver, associated with false-positive serological tests for syphilis and an antibody active against stored red cells, is presented. Methods used in the identification of the ;stored red cell' antibody are described. ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.18.4.460
更新日期:1965-07-01 00:00:00
abstract::Neutropenia is a rare complication of Diamond-Blackfan syndrome (congenital hypoplastic anaemia). Three patients are reported: all had neutropenia as well as anaemia, and to investigate the cause of the neutropenia culture of bone marrow for granulocyte-macrophage colony forming cells (GMCFCs) was performed. Two cases...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.44.9.742
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:The Sysmex XN haematology instrument performs automatic reflex testing, depending on sample results. A nucleated red blood cell (NRBC) count is provided on all samples. The instrument has a smaller footprint (34%) than previous Sysmex XE analysers. METHODS:An evaluation comparing all results to the Sysmex X...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2012-200930
更新日期:2012-11-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2013-201662
更新日期:2014-04-01 00:00:00
abstract::Thirty-seven percutaneous renal biopsies showing no significant abnormalities on light microscopy were studied electron optically and by immunofluorescence when available. Assessment of the pathological material was followed by analysis of the patients' clinical notes, and a clinicopathological correlation was carried...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.29.5.380
更新日期:1976-05-01 00:00:00
abstract::Purulent exudate from 28 cases of Bartholin's abscess were examined for aerobic, anaerobic, and microaerophilic bacteria. Three cases gave no bacterial growth, five cases grew facultative bacteria only, and a further three grew a mixture of facultative and anaerobic bacteria. One case gave a pure growth of a microaero...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.30.11.1025
更新日期:1977-11-01 00:00:00
abstract::A case of nodular regenerative hyperplasia (NRH) of the liver is described in association with exposure to the radiographic contrast medium Thorotrast. This is the first case in which the pathological findings have been fully documented. It is suggested that NRH may have developed through Thorotrast induced damage to ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jcp.51.12.941
更新日期:1998-12-01 00:00:00
abstract:AIMS:To evaluate the efficacy of biochemical parameters in different fluids in the diagnosis of myocardial infarction of different causes, analysed after death. METHODS:The myoglobin concentration and total creatine kinase (CK) and creatine kinase MB isoenzyme (CK-MB) activities were measured in serum, pericardial flu...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.48.2.124
更新日期:1995-02-01 00:00:00
abstract::The effect of the new beta-lactam antibiotic FL 1060 on urinary tract pathogens, of which 71 were sensitive to and 100 resistant to ampicillin, is presented here. When tested by conventional methods FL 1060 was found to be highly active against ampicillin-sensitive strains of E. coli but phenotypically resistant varia...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.27.3.192
更新日期:1974-03-01 00:00:00
abstract::Michaëlsson's (1961) method for the measurement of plasma bilirubin concentration was found to be complicated by conjugated bilirubin. Delaying the addition of the accelerator, diphylline, corrected this fault. The method was calibrated using serum or plasma, since reconstituted protein solutions introduced large erro...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.22.4.439
更新日期:1969-07-01 00:00:00
abstract::The use of the dye calcon (1-(2 hydroxy-1-naphthylazo)-2-naphthol-4 sulphonic acid) for the estimation of calcium using E.D.T.A. and a commercial photoelectric titrimeter is described. The interfering effects of magnesium and phosphate have been overcome. The method has been extended to estimations on biological mater...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.16.1.18
更新日期:1963-01-01 00:00:00
abstract:AIM:To investigate the tissue specificity of a novel monoclonal antibody raised to a tissue fraction of normal human liver and which identified certain cells of gastric and duodenal mucosa. METHODS:A total of 155 samples of various tissues obtained from 100 surgical specimens were fixed in cold ethanol-paraformaldehyd...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.47.1.53
更新日期:1994-01-01 00:00:00