Positive end-expiratory pressure preserves surfactant function in preterm lambs.

abstract：:To better understand strategies for recruiting and maintaining lung volume in acute lung injury, we examined relationships between steady-state lung volume and cumulative cyclic recruitment/derecruitment volume history and the quasi-static pressure-volume curve, in an animal saline lavage lung injury model. Small-volu...

journal_title：American journal of respiratory and critical care medicine

authors： Downie JM,Nam AJ,Simon BA

更新日期：2004-04-15 00:00:00

abstract：RATIONALE:Corticosteroids are the antiinflammatory treatment of choice in asthma. Treatment guidelines are mainly symptom-driven but symptoms are not closely related to airway inflammation. The fraction of nitric oxide in exhaled air (FENO) is a marker of airway inflammation in asthma. OBJECTIVE:We evaluated whether t...

journal_title：American journal of respiratory and critical care medicine

authors： Pijnenburg MW,Bakker EM,Hop WC,De Jongste JC

更新日期：2005-10-01 00:00:00

abstract：:We enrolled nine allergic subjects in a double blind, placebo-controlled study to examine the effect of premedication with 0.6 mg of atropine on nasal antigen challenge. The challenge consisted of unilaterally stimulating the nasal septum with diluent followed by three increasing doses of antigen and recording respons...

journal_title：American journal of respiratory and critical care medicine

authors： Baroody FM,Ford S,Lichtenstein LM,Kagey-Sobotka A,Naclerio RM

更新日期：1994-06-01 00:00:00

abstract：:Obstructive sleep apnea causes cardiovascular morbidity and premature death. Potential links between sleep apnea and cardiovascular complications are chronically elevated activity of the sympathetic nervous system and abnormal vascular function. To explore vascular function, we determined the reactive hyperemic blood ...

journal_title：American journal of respiratory and critical care medicine

authors： Imadojemu VA,Gleeson K,Quraishi SA,Kunselman AR,Sinoway LI,Leuenberger UA

更新日期：2002-04-01 00:00:00

abstract：:To compare the effectiveness of information delivered to family members of critically ill patients by junior and senior physicians, we performed a prospective randomized multicenter trial in 11 French intensive care units. Patients (n = 220) were allocated at random to having their family members receive information b...

journal_title：American journal of respiratory and critical care medicine

authors： Moreau D,Goldgran-Toledano D,Alberti C,Jourdain M,Adrie C,Annane D,Garrouste-Orgeas M,Lefrant JY,Papazian L,Quinio P,Pochard F,Azoulay E

更新日期：2004-02-15 00:00:00

abstract：RATIONALE:Airways obstruction with thick, adherent mucus is a pathophysiologic and clinical feature of muco-obstructive respiratory diseases, including chronic obstructive pulmonary disease, asthma, and cystic fibrosis (CF). Mucins, the dominant biopolymer in mucus, organize into complex polymeric networks via the form...

journal_title：American journal of respiratory and critical care medicine

authors： Ehre C,Rushton ZL,Wang B,Hothem LN,Morrison CB,Fontana NC,Markovetz MR,Delion MF,Kato T,Villalon D,Thelin WR,Esther CR Jr,Hill DB,Grubb BR,Livraghi-Butrico A,Donaldson SH,Boucher RC

更新日期：2019-01-15 00:00:00

abstract：:We hypothesized that ischemia/reperfusion (I/R) injury of the liver during normotensive gram-negative bacteremic sepsis alters the kinetics of circulating endotoxin, tumor necrosis factor-alpha (TNF-alpha), and coinduced mediators, thereby exacerbating sepsis-induced lung inflammation. Liver and lung dysfunction were ...

journal_title：American journal of respiratory and critical care medicine

authors： Matuschak GM,Henry KA,Johanns CA,Lechner AJ

更新日期：2001-03-01 00:00:00

abstract：:Ventilation was measured in 31 difficult-to-wean patients while pressure support (PS) was reduced by 5 cm H2O every 20 min. Weaning had to be aborted in 14 of 31 patients (Group F) because they met predefined distress criteria. The remaining 17 patients who were able to complete the "weaning test" (Group S) had larger...

journal_title：American journal of respiratory and critical care medicine

authors： Stroetz RW,Hubmayr RD

更新日期：1995-09-01 00:00:00

abstract：:The aim of this study was to assess the influence of preservation solution type and extra- or intracellular composition on the occurrence of early graft dysfunction after clinical lung transplantation. For 170 patients who underwent a single (n = 124) or bilateral (n = 46) lung transplantation in two centers in Paris ...

journal_title：American journal of respiratory and critical care medicine

authors： Thabut G,Vinatier I,Brugière O,Lesèche G,Loirat P,Bisson A,Marty J,Fournier M,Mal H

更新日期：2001-10-01 00:00:00

abstract：:In normal airways, invasion of small numbers of pathogenic bacteria will not give rise to injury or local colonization. In chronic obstructive pulmonary disease, however, local conditions are changed, which may impair local defense systems and facilitate infection. These include: (1) factors promoting bacterial adhere...

journal_title：American journal of respiratory and critical care medicine

authors： Jansen HM,Sachs AP,van Alphen L

更新日期：1995-06-01 00:00:00

abstract：:Selected events in rhinovirus infection of the normal human airway can be regarded as occurring sequentially. Initial steps in rhinovirus pathogenesis are believed to include viral entry into the nose, mucociliary transport of virus to the posterior pharynx, and initiation of infection in ciliated and non-ciliated epi...

journal_title：American journal of respiratory and critical care medicine

authors： Gwaltney JM Jr

更新日期：1995-10-01 00:00:00

abstract：RATIONALE:Exhaled nitric oxide (NO) is a well-known marker of established airway inflammation in asthma. Its role in the disease process before the onset of respiratory symptoms remains unclear. OBJECTIVES:To examine whether elevated NO in newborns with clinically naive airways is associated with subsequent respirator...

journal_title：American journal of respiratory and critical care medicine

authors： Latzin P,Kuehni CE,Baldwin DN,Roiha HL,Casaulta C,Frey U

更新日期：2006-12-15 00:00:00

abstract：:This study was designed to evaluate the value and applicability of tidal breathing pattern analysis to assess airflow obstruction in young children. The time needed to reach maximal tidal expiratory flow (TME) divided by total expiratory time (TE) was measured in 228 healthy children 3 to 11 yr of age, 64 patients wit...

journal_title：American journal of respiratory and critical care medicine

authors： van der Ent CK,Brackel HJ,van der Laag J,Bogaard JM

更新日期：1996-04-01 00:00:00

abstract：:We examined the efficacy and the acceptance of an oral device (SnorEx) causing a forward displacement of the tongue for the treatment of sleep-disordered breathing (SDB). Twenty-three consecutive subjects with SDB were investigated. Noncompliance (NC) of use of the oral appliance was observed in 74% (17 of 23) of the ...

journal_title：American journal of respiratory and critical care medicine

authors： Schönhofer B,Stoohs RA,Rager H,Wenzel M,Wenzel G,Köhler D

更新日期：1997-02-01 00:00:00

abstract：:Bronchial hyperresponsiveness (BHR), the increased sensitivity to a wide variety of stimuli that narrow the airways, is a central abnormality in patients with asthma, and is frequently observed in patients with chronic obstructive pulmonary disease. In the study of the underlying mechanisms of BHR, various animal mode...

journal_title：American journal of respiratory and critical care medicine

authors： Rabe KF

更新日期：1998-11-01 00:00:00

abstract：:Possible mechanisms involved in inhaled sodium metabisulfite (MBS)-induced bronchoconstriction include cholinergic reflex and release of tachykinins from sensory nerve endings. Tachykinins are potent bronchoconstrictors cleaved and inactivated by neutral endopeptidase (NEP) in the airways. To investigate the role of t...

journal_title：American journal of respiratory and critical care medicine

authors： Bellofiore S,Caltagirone F,Pennisi A,Ciancio N,Mistretta A,Di Maria GU

更新日期：1994-09-01 00:00:00

abstract：:Endothelins (ET-1, ET-2, ET-3) are potent bronchoconstrictors and growth-promoting mediators. They are released from various cells such as endothelial and epithelial cells. In the airways, ETs are released under basal and stimulated conditions. In patients with status asthmaticus and other pulmonary disorders, the exp...

journal_title：American journal of respiratory and critical care medicine

authors： Yang Q,Battistini B,D'Orléans-Juste P,Jeng AY,Sirois P

更新日期：1997-06-01 00:00:00

abstract：:Rationale: Chronic hypersensitivity pneumonitis (CHP) is caused by an immune response to antigen inhalation and is characterized by variable histopathological and clinical features. A subset of subjects with CHP have usual interstitial pneumonia and appear to be clinically similar to subjects with idiopathic pulmonary...

journal_title：American journal of respiratory and critical care medicine

authors： Furusawa H,Cardwell JH,Okamoto T,Walts AD,Konigsberg IR,Kurche JS,Bang TJ,Schwarz MI,Brown KK,Kropski JA,Rojas M,Cool CD,Lee JS,Wolters PJ,Yang IV,Schwartz DA

更新日期：2020-11-15 00:00:00

abstract：:It has been nearly a century since the first suggestion that a soluble factor in plasma or serum might be responsible for the symptoms of allergic disease and asthma, and more than 30 yr since immunoglobulin E (IgE) was identified as the key molecule in mediating what are now described as type 1 hypersensitivity react...

journal_title：American journal of respiratory and critical care medicine

authors： Platts-Mills TA

更新日期：2001-10-15 00:00:00

abstract：:Sensitive measures of lung function applicable to young subjects are needed to detect early cystic fibrosis (CF) lung disease. Forty children with CF aged 2 to 5 years and 37 age-matched healthy control subjects performed multiple-breath inert gas washout, plethysmography, and spirometry. Thirty children in each group...

journal_title：American journal of respiratory and critical care medicine

authors： Aurora P,Bush A,Gustafsson P,Oliver C,Wallis C,Price J,Stroobant J,Carr S,Stocks J,London Cystic Fibrosis Collaboration.

更新日期：2005-02-01 00:00:00

abstract：RATIONALE:Density-based morphometric studies have demonstrated decreased capillary density in infants with bronchopulmonary dysplasia (BPD) and in BPD-like animal models, leading to the prevailing view that microvascular development is disrupted in BPD. OBJECTIVE:To perform a comprehensive analysis of the early and la...

journal_title：American journal of respiratory and critical care medicine

authors： De Paepe ME,Mao Q,Powell J,Rubin SE,DeKoninck P,Appel N,Dixon M,Gundogan F

更新日期：2006-01-15 00:00:00

abstract：:State-dependent changes in upper airway caliber were studied with magnetic resonance imaging (MRI) techniques. We hypothesized that changes in airway caliber during sleep in normal subjects would result from positional and dimensional changes in upper airway soft-tissue structures, including the lateral pharyngeal wal...

journal_title：American journal of respiratory and critical care medicine

authors： Trudo FJ,Gefter WB,Welch KC,Gupta KB,Maislin G,Schwab RJ

更新日期：1998-10-01 00:00:00

abstract：:We surveyed pulmonologists to determine which procedures they do in practice, where they learned the procedures, and how much training they recommend to attain and maintain clinical competence in each. We mailed a survey to a random sample of 1,000 members of the American College of Physicians who were identified as p...

journal_title：American journal of respiratory and critical care medicine

authors： Tape TG,Blank LL,Wigton RS

更新日期：1995-02-01 00:00:00

abstract：RATIONALE:Airway remodeling is an important feature of chronic asthma that causes irreversible airflow obstruction. Although asthma is considered to be a Th2 disease, the role of T-bet and GATA-3, the key transcription factors for differentiation toward Th1 and Th2 cells, in the pathogenesis of airway remodeling is poo...

journal_title：American journal of respiratory and critical care medicine

authors： Kiwamoto T,Ishii Y,Morishima Y,Yoh K,Maeda A,Ishizaki K,Iizuka T,Hegab AE,Matsuno Y,Homma S,Nomura A,Sakamoto T,Takahashi S,Sekizawa K

更新日期：2006-07-15 00:00:00

abstract：:Rationale: Sleep-disordered breathing (SDB) is associated with increased vascular resistance in children and adults. Persistent increased vascular resistance damages vascular endothelial cells-a marker of which is increased platelet activation.Objectives: This study compared whole-blood impedance platelet aggregation ...

journal_title：American journal of respiratory and critical care medicine

authors： Kontos A,Willoughby S,Lushington K,Martin J,Wabnitz D,Dorrian J,Kennedy D

更新日期：2020-12-01 00:00:00

abstract：RATIONALE:Outcome measures that integrate mortality and morbidity, like quality-adjusted life years (QALYs), have been proposed for critical care clinical trials. OBJECTIVES:We sought to describe the distribution of QALYs in critically ill patients and estimate sample size requirements for a hypothetical trial using Q...

journal_title：American journal of respiratory and critical care medicine

authors： Ferguson ND,Scales DC,Pinto R,Wilcox ME,Cook DJ,Guyatt GH,Schünemann HJ,Marshall JC,Herridge MS,Meade MO,Canadian Critical Care Trials Group.

更新日期：2013-02-01 00:00:00

abstract：:Increased pharyngeal collapsibility and abnormal anatomic structures have been postulated to contribute to the pathophysiology of obstructive sleep apnea (OSA) syndrome. It is unclear whether the abnormal craniofacial and soft tissue features may affect the pharyngeal collapsibility and contribute to the apnea density...

journal_title：American journal of respiratory and critical care medicine

authors： Sforza E,Bacon W,Weiss T,Thibault A,Petiau C,Krieger J

更新日期：2000-02-01 00:00:00

abstract：:In this case-control family study of sleep-disordered breathing (SDB), we describe the distributions of SDB and SDB risk factors in African-Americans and Caucasians. A total of 225 African-Americans and 622 Caucasians, ages 2 to 86 yr, recruited as members of families with an individual with known sleep apnea (85 inde...

journal_title：American journal of respiratory and critical care medicine

authors： Redline S,Tishler PV,Hans MG,Tosteson TD,Strohl KP,Spry K

更新日期：1997-01-01 00:00:00

abstract：RATIONALE:Obstructive sleep apnea (OSA) is associated with systemic hypertension. Either overnight intermittent hypoxia, or the recurrent arousals that occur in OSA, could cause the daytime increases in blood pressure (BP). OBJECTIVES:To establish the role of intermittent hypoxia in the increased morning BP in patient...

journal_title：American journal of respiratory and critical care medicine

authors： Turnbull CD,Sen D,Kohler M,Petousi N,Stradling JR

更新日期：2019-01-15 00:00:00

abstract：RATIONALE:5-Hydroxytryptamine (5-HT) is involved in the pathogenesis of allergic airway inflammation (AAI). It is unclear, however, how 5-HT contributes to AAI and whether this depends on tryptophan hydroxylase (TPH) 1, the critical enzyme for peripheral 5-HT synthesis. OBJECTIVES:To elucidate the role of TPH1 and the...

journal_title：American journal of respiratory and critical care medicine

authors： Dürk T,Duerschmied D,Müller T,Grimm M,Reuter S,Vieira RP,Ayata K,Cicko S,Sorichter S,Walther DJ,Virchow JC,Taube C,Idzko M

更新日期：2013-03-01 00:00:00