Abstract:
:A comprehensive nonredundant database of 475 cocrystallized protein-protein complexes was used to study low-resolution recognition, which was reported in earlier docking experiments with a small number of proteins. The docking program GRAMM was used to delete the atom-size structural details and systematically dock the resulting molecular images. The results reveal the existence of the low-resolution recognition in 52% of all complexes in the database and in 76% of the 113 complexes with an interface area >4,000 A(2). Limitations of the docking and analysis tools used in this study suggest that the actual number of complexes with the low-resolution recognition is higher. However, the results already prove the existence of the low-resolution recognition on a broad scale.
journal_name
Proc Natl Acad Sci U S Aauthors
Vakser IA,Matar OG,Lam CFdoi
10.1073/pnas.96.15.8477keywords:
subject
Has Abstractpub_date
1999-07-20 00:00:00pages
8477-82issue
15eissn
0027-8424issn
1091-6490journal_volume
96pub_type
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