The electroreceptor organ of the catfish, Ictalurus melas, as a model for cisplatin-induced ototoxicity.

abstract：:In the past 15 years the classical view that astrocytes play a relatively passive role in brain function has been overturned and it has become increasingly clear that signaling between neurons and astrocytes may play a crucial role in the information processing that the brain carries out. This new view stems from two ...

journal_title：Neuroscience

authors： Santello M,Volterra A

更新日期：2009-01-12 00:00:00

abstract：:To better understand the function of the Wnt pathway in the developing telencephalon, we analyzed neocortical development in low density lipoprotein receptor-related protein (LRP) 6 mutants. LRP6 mutant mice are hypomorphic for the canonical Wnt signaling pathway and have hypoplasia of the developing neocortex. While ...

journal_title：Neuroscience

authors： Zhou CJ,Borello U,Rubenstein JL,Pleasure SJ

更新日期：2006-11-03 00:00:00

abstract：:Intrathecally-administered endomorphin-1 and endomorphin-2 produce antinociceptive effects which are different from each other. In order to elucidate a cellular basis for this result, we examined the effects of endomorphin-1 and endomorphin-2 on holding currents and spontaneous glutamatergic excitatory transmission in...

journal_title：Neuroscience

authors： Fujita T,Kumamoto E

更新日期：2006-01-01 00:00:00

abstract：:In partially denervated skeletal muscle, spared motor fibres sprout, enlarging motor unit size. Neuritogenesis and sprouting are known to depend on the synaptic input to the neurons. This suggests that spared motoneuron reaction to partial muscle denervation might be controlled by primary sensory neurons which directl...

journal_title：Neuroscience

authors： Cuppini R,Ambrogini P,Sartini S

更新日期：1998-05-01 00:00:00

abstract：:There is increasing evidence indicating that estrogen replacement therapy produces neuroprotective actions but has undesirable side effects on the reproductive system. Raloxifene is a selective estrogen receptor modulator that exerts estrogen agonist action in the brain while acting as an estrogen antagonist in the re...

journal_title：Neuroscience

authors： Huang Y,Huang YL,Lai B,Zheng P,Zhu YC,Yao T

更新日期：2007-06-29 00:00:00

abstract：:Most patients with temporal lobe epilepsy (TLE), the most common type of epilepsy, show pronounced loss of neurons in limbic brain regions, including the hippocampus. The massive neurodegeneration in the hippocampus is known as hippocampal sclerosis, and is considered one of the hallmarks of this type of difficult-to-...

journal_title：Neuroscience

authors： Brandt C,Potschka H,Löscher W,Ebert U

更新日期：2003-01-01 00:00:00

abstract：:Rats were trained in a specially designed apparatus to detect brief, unpredictable visual stimuli presented to either side of the head. In one condition, rats reported the detection of the visual stimulus by removing their heads from a central location and responding in one of two adjacent side-holes where the visual ...

journal_title：Neuroscience

authors： Carli M,Jones GH,Robbins TW

更新日期：1989-01-01 00:00:00

abstract：:After experimentally inducing long term changes in transmitter release, a series of frog neuromuscular junctions were studied with intracellular recording and then semi-serially sectioned and examined in the electron microscope. Transmitter release per unit length of motor nerve terminal was well correlated with sever...

journal_title：Neuroscience

authors： Herrera AA,Grinnell AD,Wolowske B

更新日期：1985-11-01 00:00:00

abstract：:While the effects of progesterone in the CNS, like those of estrogen, have generally been considered within the context of reproductive function, growing evidence supports its importance in regulating non-reproductive functions including cognition and affect. In addition, progesterone has well-described protective eff...

journal_title：Neuroscience

authors： Singh M,Su C

更新日期：2013-06-03 00:00:00

abstract：:The distribution of the diadenosine tetraphosphate high-affinity binding sites has been studied in rat brain by an autoradiographic method using [3H]diadenosine tetraphosphate as the ligand. The binding characteristics are comparable to those described in studies performed on rat brain synaptosomes. White matter is de...

journal_title：Neuroscience

authors： Rodríguez-Pascual F,Cortes R,Torres M,Palacios JM,Miras-Portugal MT

更新日期：1997-03-01 00:00:00

abstract：:Striatal dopamine D2 receptors activate the PLC → IP3 → Calcineurin-signaling pathway to modulate the neural excitability of En+ Medium-sized Spiny GABAergic neurons (MSN) through the regulation of L-type Ca2+ channels. Presynaptic dopaminergic D2 receptors modulate GABA release at striatopallidal terminals through L-...

journal_title：Neuroscience

authors： Jijón-Lorenzo R,Caballero-Florán IH,Recillas-Morales S,Cortés H,Avalos-Fuentes JA,Paz-Bermúdez FJ,Erlij D,Florán B

更新日期：2018-02-21 00:00:00

abstract：:Accumulated evidence suggests that the single transmembrane domain insulin-like growth factor-II/mannose 6-phosphate receptor (IGF-II/M6P or IGF-II receptor) plays an important role in the intracellular trafficking of lysosomal enzymes and endocytosis-mediated degradation of insulin like growth factor (IGF-II). Howeve...

journal_title：Neuroscience

authors： Amritraj A,Rauw G,Baker GB,Kar S

更新日期：2010-10-27 00:00:00

abstract：:The possible roles of G-protein coupled metabotropic glutamate receptors in central nervous function are currently the focus of intensive investigation. The complexity of effects produced by agonists at these receptors probably reflects the activity of a range of sub-types. The metabotropic glutamate receptors first d...

journal_title：Neuroscience

authors： Birse EF,Eaton SA,Jane DE,Jones PL,Porter RH,Pook PC,Sunter DC,Udvarhelyi PM,Wharton B,Roberts PJ

更新日期：1993-02-01 00:00:00

abstract：:Plethodontid salamanders display intricate courtship behaviors. Proteinaceous courtship pheromones were recently discovered in the submandibular (mental) gland of the male Plethodon shermani, the red-legged salamander. Behavioral studies showed that these male pheromones are delivered by direct contact to the female s...

journal_title：Neuroscience

authors： Laberge F,Feldhoff RC,Feldhoff PW,Houck LD

更新日期：2008-01-24 00:00:00

abstract：:Several lines of evidence have demonstrated the presence of three opioid receptor types in the CNS and periphery. These receptors are referred to as mu, delta and kappa, and have been implicated in a wide variety of functions. The present study examines the localization of the kappa 1 receptor, a region of the recepto...

journal_title：Neuroscience

authors： Mansour A,Burke S,Pavlic RJ,Akil H,Watson SJ

更新日期：1996-04-01 00:00:00

abstract：:Huntington's disease is a genetic disease, autosomal and dominant, that induces motor disorders, an inexorable deterioration of higher brain functions and psychiatric disturbances. At present, there are no known therapeutics against Huntington's disease. The Network of European CNS Transplantation and Restoration (NEC...

journal_title：Neuroscience

authors： Peschanski M,Cesaro P,Hantraye P

更新日期：1995-09-01 00:00:00

abstract：:The blockade of the central nucleus of the amygdala (CeA) with the GABAA receptor agonist muscimol significantly reduces hypertonic NaCl and water intake by sodium-depleted rats. In the present study we investigated the effects of previous injection of losartan, an angiotensin II type-1 (AT1) receptor antagonist, into...

journal_title：Neuroscience

authors： Hu B,Qiao H,Sun B,Jia R,Fan Y,Wang N,Lu B,Yan JQ

更新日期：2015-10-29 00:00:00

abstract：:Tg2576 transgenic mice (mice overexpressing the "Swedish" mutation in the human amyloid precursor protein 695) demonstrated a decreased capacity for cell proliferation in the dentate gyrus of the hippocampus compared with non-transgenic littermates at 3 months, 6 months and 9 months of age. Isolation stress induced by...

journal_title：Neuroscience

authors： Dong H,Goico B,Martin M,Csernansky CA,Bertchume A,Csernansky JG

更新日期：2004-01-01 00:00:00

abstract：:Handedness in humans and paw preference (PP) in rodents have been associated with neural and physiological correlates, which frequently appear to be sex-specific. The present study examines sex differences in the effects of differential PP on post mortem measures of regional monoamine activity in adult Long-Evans rats...

journal_title：Neuroscience

authors： Sullivan RM,Chehab SL,Dufresne MM,Laplante F

更新日期：2012-01-27 00:00:00

abstract：:Many behaviorally relevant sounds, including language, are composed of brief, rapid, repetitive acoustic features. Recent studies suggest that abnormalities in producing and understanding spoken language are correlated with abnormal neural responsiveness to such auditory stimuli at higher auditory levels [Tallal et al...

journal_title：Neuroscience

authors： Bartlett EL,Smith PH

更新日期：2002-01-01 00:00:00

abstract：:In vitro cell cultures are an important tool for obtaining insights into cellular processes in an isolated system and a supplement to in vivo animal experiments. While primary dissociated cultures permit a single homogeneous cell population to be studied, there is a clear need to explore the function of brain cells in...

journal_title：Neuroscience

authors： Humpel C

更新日期：2015-10-01 00:00:00

abstract：:To investigate whether cholinergic hypofunctions in the brain influence hypothalamic-pituitary-adrenal activity, we examined the effects of cholinergic neurotoxin ethylcholine mustard aziridinium ion on basal and stress-induced levels of corticosterone in rats. Blood sampling from rats following intracerebroventricula...

journal_title：Neuroscience

authors： Endo Y,Yamauchi K,Fueta Y

更新日期：2001-01-01 00:00:00

abstract：:Parkinson's disease patients who suffer from freezing of gait (PD-FOG) may have sensory and/or perceptual deficits, although they are difficult to disentangle. This study evaluated whether visuospatial perception or self-motion perception were more impaired in PD-FOG, and whether distance estimation errors might be re...

journal_title：Neuroscience

authors： Ehgoetz Martens KA,Ellard CG,Almeida QJ

更新日期：2014-08-22 00:00:00

abstract：:The role of Orphanin-FQ/nociceptin in synaptic plasticity was assessed by its potency in modulating kindling epileptogenesis in vivo, and feed-forward inhibition in hippocampal recordings in vitro. In addition, a specific rabbit antiserum against this peptide was obtained and the immunohistochemical distribution of no...

journal_title：Neuroscience

authors： Gutiérrez R,Leff P,Romo-Parra H,Acevedo R,Antón B

更新日期：2001-01-01 00:00:00

abstract：:Factors involved in the production of long-term potentiation in the CA1 region of rat hippocampal slices were examined using whole-cell voltage clamp recordings. The pairing of postsynaptic membrane depolarization with tetanic stimulation produced a reliable long-lasting enhancement of synaptic currents provided that ...

journal_title：Neuroscience

authors： Kato K,Clifford DB,Zorumski CF

更新日期：1993-03-01 00:00:00

abstract：:Microtubule-associated protein 1B is a major constituent of the neuronal cytoskeleton during the early stages of development. This protein and its phosphorylated isoform, microtubule-associated protein 1B-P, defined by the monoclonal antibody 1B-P [Boyne L. J. et al. (1995) J. Neurosci. Res. 40, 439-450], are present ...

journal_title：Neuroscience

authors： Ma D,Connors T,Nothias F,Fischer I

更新日期：2000-01-01 00:00:00

abstract：:Having provided an anatomical description of the efferent projections of the dorsal midbrain anticonvulsant zone [Shehab S. et al. (1995) Neuroscience 65, 681-695], our purpose in the present study was to establish which outputs from this region are responsible for mediating the anticonvulsant and behavioural properti...

journal_title：Neuroscience

authors： Shehab S,Simkins M,Dean P,Redgrave P

更新日期：1995-04-01 00:00:00

abstract：:Neurons of the efferent vestibular system were investigated in the cat using retrograde axonal transport of horseradish peroxidase and fluorescent retrograde double labelling techniques. The number of efferent neurons was clearly higher than previously reported. A three dimensional reconstruction of the location of th...

journal_title：Neuroscience

authors： Dechesne C,Raymond J,Sans A

更新日期：1984-04-01 00:00:00

abstract：:The protective effect of diphenyliodonium, known as an inhibitor of flavin enzymes including nitric oxide synthases, was examined against the neurotoxicity of excitatory amino acids on cultured spinal neurons of the rat. Diphenyliodonium reduced the neuronal damage induced by 15-min exposure to glutamate or N-methyl-D...

journal_title：Neuroscience

authors： Nakamura Y,Tsuji K,Shuto M,Ogita K,Yoneda Y,Shimamoto K,Shibata T,Kataoka K

更新日期：1997-01-01 00:00:00

abstract：:Loyez' myelin stain sometimes impregnates the perikarya and processes of neurons. This is rare in normal adult mice, but can be provoked by various means including electrical stimulation and mild ischaemia shortly before fixation. Passing a direct current or a train of pulses across the dura of the cerebral cortex pro...

journal_title：Neuroscience

authors： Clarke PG,Nussbaumer JC

更新日期：1987-12-01 00:00:00