Effect of intraluminal oxygen on experimental ischaemia of the intestine.

abstract：BACKGROUND:The use of corticosteroids in active Crohn's disease often becomes limited by side effects. Budesonide is a potent corticosteroid with low systemic bioavailability due to an extensive first pass liver metabolism. AIMS:To compare the efficacy and safety of two dosage regimens of budesonide and prednisolone i...

journal_title：Gut

authors： Campieri M,Ferguson A,Doe W,Persson T,Nilsson LG

更新日期：1997-08-01 00:00:00

abstract：:It has been found that a ;gastric' type of epithelium tends to develop in the first part of the duodenum in patients with duodenal ulceration and is found in the second part of the duodenum in a patient with the Zollinger-Ellison syndrome. It is likely that ;gastric' epithelium appears when the duodenal acidity is hig...

journal_title：Gut

authors： JAMES AH

更新日期：1964-08-01 00:00:00

abstract：:The disposition of antipyrine following oral administration of 1200 mg has been investigated in 10 patients with histologically confirmed hepatosplenic schistosomiasis and 11 normal subjects living in Sudan. Drug metabolising activity as assessed by antipyrine clearance was similar in patients when compared with norma...

journal_title：Gut

authors： Homeida M,Salih SY,Branch RA

更新日期：1978-09-01 00:00:00

abstract：OBJECTIVE:Hepatocellular carcinoma (HCC) is a heterogeneous tumour displaying a complex variety of genetic and epigenetic changes. In human cancers, aberrant post-transcriptional modifications, such as alternative splicing and RNA editing, may lead to tumour specific transcriptome diversity. DESIGN:By utilising large ...

journal_title：Gut

authors： Chan TH,Lin CH,Qi L,Fei J,Li Y,Yong KJ,Liu M,Song Y,Chow RK,Ng VH,Yuan YF,Tenen DG,Guan XY,Chen L

更新日期：2014-05-01 00:00:00

abstract：AIMS:To determine the sources of founding for UK gastroenterology research papers and the relative impact of papers funded by different groups and of unfunded ones. METHODS:UK gastroenterology papers from 1988-94 were selectively retrieved from the Science Citation Index by means of a specially constructed filter base...

journal_title：Gut

authors： Lewison G

更新日期：1998-08-01 00:00:00

abstract：OBJECTIVE:Non-alcoholic fatty liver disease (NAFLD) is a frequent complication of morbid obesity, but its severity varies greatly and thus there is a strong need to better define its natural history in these patients. DESIGN:Liver biopsies were systematically performed in 798 consecutive patients with severe obesity u...

journal_title：Gut

authors： Bedossa P,Tordjman J,Aron-Wisnewsky J,Poitou C,Oppert JM,Torcivia A,Bouillot JL,Paradis V,Ratziu V,Clément K

更新日期：2017-09-01 00:00:00

abstract：:The secretory response of gastric acid to pure ethanol and alcoholic beverages may be different because the action of the non-ethanolic contents of the beverage may overwhelm that of ethanol. Pure ethanol in low concentrations (< 5% vol/vol) is a mild stimulant of acid secretion whereas at higher concentrations it has...

journal_title：Gut

authors： Chari S,Teyssen S,Singer MV

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND:Colonoscopic surveillance for hereditary non-polyposis colorectal cancer (HNPCC) reduces death rates, but early interval cancers still occur, probably due to missed small, aggressive adenomas. Narrow band imaging (NBI), a novel endoscopic technology, highlights superficial mucosal capillaries and improves co...

journal_title：Gut

authors： East JE,Suzuki N,Stavrinidis M,Guenther T,Thomas HJ,Saunders BP

更新日期：2008-01-01 00:00:00

abstract：:Cholestasis of pregnancy is associated with increased fetal morbidity and mortality and should be treated actively. The significance attached to pruritus in pregnancy is often minimal, but it is a cardinal symptom of cholestasis of pregnancy, which may have no other clinical features. Eight women with previous cholest...

journal_title：Gut

authors： Davies MH,da Silva RC,Jones SR,Weaver JB,Elias E

更新日期：1995-10-01 00:00:00

abstract：:Tumour cell membrane fatty acid composition was investigated using an animal model of colorectal carcinogenesis. Eighty six male Wistar rats were fed experimental diets containing either 5% saturated fat or 20% saturated fat. Colorectal tumours were induced by intraperitoneal injection of azoxymethane, and control rat...

journal_title：Gut

authors： Nicholson ML,Neoptolemos JP,Clayton HA,Talbot IC,Bell PR

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:The pre-malignant gastric lesions atrophic gastritis (AG), intestinal metaplasia (IM) and dysplasia (DYS) have long been identified as principal risk factors for gastric cancer. OBJECTIVE:To evaluate epidemiological time trends of pre-malignant gastric lesions in the Netherlands. METHODS:Patients with a fi...

journal_title：Gut

authors： de Vries AC,Meijer GA,Looman CW,Casparie MK,Hansen BE,van Grieken NC,Kuipers EJ

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVE:Polycystic liver diseases (PCLDs) are genetic disorders characterised by progressive bile duct dilatation and/or cyst development. Their pathogenesis is a consequence of hyperproliferation, hypersecretion and microRNA alterations in cholangiocytes. Here we evaluate the role of matrix metalloproteases (MMPs) i...

journal_title：Gut

authors： Urribarri AD,Munoz-Garrido P,Perugorria MJ,Erice O,Merino-Azpitarte M,Arbelaiz A,Lozano E,Hijona E,Jiménez-Agüero R,Fernandez-Barrena MG,Jimeno JP,Marzioni M,Marin JJ,Masyuk TV,LaRusso NF,Prieto J,Bujanda L,Banales JM

更新日期：2014-10-01 00:00:00

abstract：:A clinical, biochemical, and pathological study is recorded of 50 patients in whom a diagnosis of idiopathic steatorrhea had been made and who had ;flat' jejunal biopsies. It is suggested that there is an underlying constitutional defect, not yet clearly defined, and that possibly secondary intestinal infection allows...

journal_title：Gut

authors： COOKE WT,FONE DJ,COX EV,MEYNELL MJ,GADDIE R

更新日期：1963-09-01 00:00:00

abstract：BACKGROUND:Murine postoperative ileus results from intestinal inflammation triggered by manipulation-induced mast cell activation. As its extent depends on the degree of handling and subsequent inflammation, it is hypothesised that the faster recovery after minimal invasive surgery results from decreased mast cell acti...

journal_title：Gut

authors： The FO,Bennink RJ,Ankum WM,Buist MR,Busch OR,Gouma DJ,van der Heide S,van den Wijngaard RM,de Jonge WJ,Boeckxstaens GE

更新日期：2008-01-01 00:00:00

abstract：:The possibility that the mode of action of sulphasalazine and its active metabolite 5-amino-salicylic acid (5ASA) involves modification of toxic oxygen metabolite production by neutrophils has been investigated by measuring the effect of these drugs on luminol-dependent chemiluminescence, superoxide release and oxygen...

journal_title：Gut

authors： Williams JG,Hallett MB

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Coeliac disease (CD) is triggered by an abnormal reaction to gluten. Peptides resulting from partially digested gluten of wheat, barley or rye cause inflammation of the small intestinal mucosa. Previous contradictory studies suggest that oats may trigger the abnormal immunological response in patien...

journal_title：Gut

authors： Comino I,Real A,de Lorenzo L,Cornell H,López-Casado MÁ,Barro F,Lorite P,Torres MI,Cebolla A,Sousa C

更新日期：2011-07-01 00:00:00

abstract：:One hundred patients who had undergone operation for duodenal ulcer (68 vagotomy and gastroenterostomy; seven vagotomy and pyloroplasty; 22 gastrectomy and three gastroenterostomy) 10 or more years previously each underwent endoscopy. Biopsies were taken and gastric juice aspirated for measurement of pH and nitrite co...

journal_title：Gut

authors： Watt PC,Sloan JM,Donaldson JD,Patterson CC,Kennedy TL

更新日期：1984-03-01 00:00:00

abstract：BACKGROUND AND AIMS:It is not known why some reflux episodes evoke symptoms and others do not. We investigated the determinants of perception of gastro-oesophageal reflux. METHODS:In 32 patients with symptoms suggestive of gastro-oesophageal reflux, 24 hour ambulatory pH and impedance monitoring was performed after ce...

journal_title：Gut

authors： Bredenoord AJ,Weusten BL,Curvers WL,Timmer R,Smout AJ

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:A long time goal of the medical research community has been the identification of a reliable and valid marker for Crohn's disease. AIM:To identify differences in the genetic expression patterns of healthy and diseased tissues. METHOD:The RNA arbitrarily primed polymerase chain reaction (RAP-PCR) procedure ...

journal_title：Gut

authors： Lafontaine DA,Mercure S,Perreault JP

更新日期：1998-06-01 00:00:00

abstract：:The amounts of lactase (EC 3.2.1.23), sucrase (EC 3.2.1.48), maltase (EC 3.2.1.20), microvillus aminopeptidase (microsomal EC3.4.11.2), and dipeptidyl peptidase IV (EC 3.4.14.X) in biopsies from proximal jejunum and distal ileum were studied by quantitative crossed immunoelectrophoresis and enzymatic assays in obese p...

journal_title：Gut

authors： Skovbjerg H,Gudmand-Høyer E,Norén O,Sjöström H

更新日期：1980-08-01 00:00:00

abstract：:Overtubes are short sleeves designed to fit over the shaft of fibrescopes. Several home made overtubes have been described. We have reviewed design principles and many potential applications, which are not widely appreciated. ...

journal_title：Gut

authors： Cotton PB

更新日期：1983-09-01 00:00:00

abstract：:A patient with myelofibrosis developed repeated gastrointestinal haemorrhage from the small intestine, which was found to be infiltrated with extramedullary haemopoiesis. Nineteen months later he presented with subacute intestinal obstruction; radiology and laparotomy documented progressive infiltration of the small b...

journal_title：Gut

authors： Sharma BK,Pounder RE,Cruse JP,Knowles SM,Lewis AA

更新日期：1986-07-01 00:00:00

abstract：:Intestinal folate absorption was assessed in six normal subjects and in four patients with coeliac sprue who were studied before and after treatment by dietary gluten exclusion. Comparisons were made of the luminal disappearance from the perfused jejunum of 3H-pteroylmonoglutamate and pteroyl 14C-glutamylhexaglutamate...

journal_title：Gut

authors： Halsted CH,Reisenauer AM,Shane B,Tamura T

更新日期：1978-10-01 00:00:00

abstract：:We have found increased small intestinal permeability to 51Cr-ethylenediaminetetra acetate in patients with ankylosing spondylitis compared with controls. There is no significant difference between patients with ankylosing spondylitis and patients with rheumatoid arthritis taking non-steroidal anti-inflammatory drugs ...

journal_title：Gut

authors： Morris AJ,Howden CW,Robertson C,Duncan A,Torley H,Sturrock RD,Russell RI

更新日期：1991-12-01 00:00:00

abstract：:Effects of [Asu1,7]-eel calcitonin on gastric somatostatin and gastrin secretion were studied by using the isolated perfused rat stomach. [Asu1,7]-eel calcitonin (10(-9)--10(-7)M) caused a simultaneous dose-dependent increase of gastric somatostatin release and decrease of gastrin secretion, with a significant correla...

journal_title：Gut

authors： Chiba T,Taminato T,Kadowaki S,Goto Y,Mori K,Seino Y,Abe H,Chihara K,Matsukura S,Fujita T,Kondo T

更新日期：1980-02-01 00:00:00

abstract：:This report presents a patient with proximal small bowel cystic pneumatosis associated with poorly controlled coeliac disease and pseudo-obstruction. Cystic pneumatosis is rare in the proximal small bowel and we can find no report of its occurrence in association with coeliac disease. ...

journal_title：Gut

authors： Sackier JM,Smith EJ,Wood CB

更新日期：1988-06-01 00:00:00

abstract：:The frequency of gastric Crohn's disease has been considered low. This study was undertaken to determine the prevalence of chronic gastritis and Helicobacter pylori infection in patients with Crohn's disease. Oesophagogastroduodenoscopy was performed on 62 consecutive patients suffering from ileocolonic Crohn's diseas...

journal_title：Gut

authors： Halme L,Kärkkäinen P,Rautelin H,Kosunen TU,Sipponen P

更新日期：1996-03-01 00:00:00

abstract：:A previous cohort study suggested that there might be an association between use of cimetidine and motor neurone disease. The Oxford Record Linkage Study was used to explore this hypothesis. In the analysis the presence of a peptic ulcer in patients after 1976 was taken as a proxy for cimetidine (and ranitidine) use. ...

journal_title：Gut

authors： Vessey MP,Goldacre MJ,Seagroatt V,Yeates D

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Interstitial cells of Cajal (ICC) are pacemakers and mediators of motor neurotransmission in gastrointestinal smooth muscles. ICC require cellular signalling via Kit, a receptor tyrosine kinase, for development and maintenance of phenotype. Much of the evidence demonstrating the functions of ICC com...

journal_title：Gut

authors： Takayama I,Daigo Y,Ward SM,Sanders KM,Walker RL,Horowitz B,Yamanaka T,Fujino MA

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Fatigue is a frequent and disabling symptom reported by patients with chronic hepatitis C (CHC). Its mechanism is poorly understood. Recent attention has focused on the role of leptin and energy expenditure in CHC. Our aims were to analyse fatigue in CHC and to determine its relationship with diseas...

journal_title：Gut

authors： Piche T,Gelsi E,Schneider SM,Hébuterne X,Giudicelli J,Ferrua B,Laffont C,Benzaken S,Hastier P,Montoya ML,Longo F,Rampal P,Tran A

更新日期：2002-09-01 00:00:00