Familial ovarian carcinoma.

Abstract:

:Familial aggregation of patients with ovarian carcinoma is unusual. A family with four affected members in three consecutive generations is described. The tumors were all of the serous papillary adenocarcinoma type. The pattern of appearance of the malignant disorder in the present family may be explained as the result of transmission of a dominant mutant autosomal gene. The future long term management of such a family might include prophylactic oophorectomy in certain family members, and possibly selective terminations of pregnancies with female fetuses in high-risk women. :A family with serous papillary adenocarcinoma of the ovary occurring in 4 members belonging to 3 consecutive generations is described. This suggests the transmission of a mutant dominant gene as a cause of the site-specific cancer. The malignant ovarian disorder has been restricted to descendants of 1 of 2 female branches of the family. In the affected family branch, 2 have had their ovaries removed prophylactically but histologically their ovarian tissues were found to be normal. There are 2 others, aged 8 and 17, who are considered to be at risk. Prophylactic ovariectomy may be indicated when they have the number of children they want. There has been no evidence of male transmission of an alleged mutant gene. In the affected branch of the family prenatal sex determination and selective abortion of female fetuses in future pregnancies may eliminate the adverse gene from this family.

journal_name

Ups J Med Sci

authors

Thor L,Persson BH,Kjessler B

doi

10.3109/03009737609179047

keywords:

subject

Has Abstract

pub_date

1976-01-01 00:00:00

pages

189-91

issue

3

eissn

0300-9734

issn

2000-1967

journal_volume

81

pub_type

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